Connecting European Neuroscience

EJN Table of Content

EJN is the official scientific journal of FENS. Sign-in to the website as a FENS member and enjoy full, free and easy access to all published articles in EJN.

  • Issue Cover

    1. Issue Cover (April 2017) (page i)

      Version of Record online: 17 APR 2017 | DOI: 10.1111/ejn.13454

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      Cover image by Dr Rafal Bogacz


    1. Introduction to the Computational Neuroscience Special Section (pages 998–999)

      Stefan Remy, Panayiota Poirazi and Athanasia Papoutsi

      Version of Record online: 17 APR 2017 | DOI: 10.1111/ejn.13562

    2. Sparse pallidal connections shape synchrony in a network model of the basal ganglia (pages 1000–1012)

      Bettina C. Schwab, Richard J. A. van Wezel and Stephan A. van Gils

      Version of Record online: 28 JUL 2016 | DOI: 10.1111/ejn.13324

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      It is still unknown how β synchrony arises in the parkinsonian basal ganglia, and what makes it dependent on dopamine. We show that in a network model, the combination of sparse, high‐conductance inhibition and sparse, low‐conductance gap junctions in the external globus pallidus could desynchronize the basal ganglia. For stronger gap junctions, activity synchronized. As dopamine decreases gap junction conductance, we suggest that gap junctions contribute to β synchrony in the parkinsonian basal ganglia.

    3. From Maxwell's equations to the theory of current‐source density analysis (pages 1013–1023)

      Sergey L. Gratiy, Geir Halnes, Daniel Denman, Michael J. Hawrylycz, Christof Koch, Gaute T. Einevoll and Costas A. Anastassiou

      Version of Record online: 28 MAR 2017 | DOI: 10.1111/ejn.13534

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      We revisit the assumptions and rigorously derive the theory of current‐source density analysis. It is shown that the extracellular potential is generally determined by the transmembrane currents as well as the putative extracellular diffusion currents, which can play an important role at the lowest frequencies. In turn, the effect of the extracellular advective and displacement currents on the extracellular potential is negligible for physiological frequencies.

    4. The possible consequences for cognitive functions of external electric fields at power line frequency on hippocampal CA1 pyramidal neurons (pages 1024–1031)

      Rosanna Migliore, Giada De Simone, Xavier Leinekugel and Michele Migliore

      Version of Record online: 26 JUL 2016 | DOI: 10.1111/ejn.13325

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      We investigated how, why and to what extent external perturbations of the intrinsic neuronal activity, such as those caused by generation, transmission and use of electrical energy [external electric fields (EF)] can affect neuronal activity during cognitive processes. Our results suggest that, although EF effects on cognitive processes may be difficult to occur in everyday life, their functional consequences deserve some consideration, especially when EF are present in a living environment.

    5. Spike‐timing dependent inhibitory plasticity to learn a selective gating of backpropagating action potentials (pages 1032–1043)

      Katharina Anna Wilmes, Jan‐Hendrik Schleimer and Susanne Schreiber

      Version of Record online: 2 AUG 2016 | DOI: 10.1111/ejn.13326

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      Feedforward inhibitory circuits can provide a switch for excitatory synaptic plasticity and BAC firing by temporally precise control of backpropagating action potentials. The precision in the circuit, however, first has to be established. This study demonstrates that an inhibitory learning rule can achieve automatic fine‐tuning of such feedforward circuits, a regulatory mechanism that allows to dynamically control learning in the nervous system.

    6. Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons (pages 1044–1056)

      Joanna Jędrzejewska‐Szmek, Sriraman Damodaran, Daniel B. Dorman and Kim T. Blackwell

      Version of Record online: 15 JUN 2016 | DOI: 10.1111/ejn.13287

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      We created a model spiny projection neuron with dendrites, spines and realistic calcium dynamics to investigate synaptic plasticity. Synaptic strength increases when calcium exceeds an upper threshold for a specified duration, and decreases when calcium is between the upper and lower threshold for a specified duration. This learning rule accurately predicts the timing‐ and NMDA‐dependence of STDP, and further predicts that L‐type calcium channels are required for LTD.

    7. Emergent spatial synaptic structure from diffusive plasticity (pages 1057–1067)

      Yann Sweeney and Claudia Clopath

      Version of Record online: 26 JUN 2016 | DOI: 10.1111/ejn.13279

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      Diffusive neurotransmitters provide a means for neurons to influence their neighbours regardless of their synaptic coupling. We propose a form of diffusive plasticity which is mediated by these neurotransmitters, and find that it introduces spatial structure in the synaptic connectivity of networks. This emergent spatial structure is reminiscent of stimulus preference structure in sensory cortex and can flexibly interact with other forms of functional synaptic organisation.


    1. Midbrain dopaminergic neuron activity across alternating brain states of urethane anaesthetized rat (pages 1068–1077)

      Magdalena Walczak and Tomasz Błasiak

      Version of Record online: 3 MAR 2017 | DOI: 10.1111/ejn.13533

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      DA neurons in the midbrains of urethane anaesthetised animals display cyclic changes in the level and pattern of firing, concomitant with the phases of cyclic alternations of cortical activation and slow wave activity. During SWA, the firing rate of DA neurons is significantly higher compared to activated state, both in VTA and SNc. During cortical SWA, DA neurons also intensify bursting activity, but this change is observed in VTA and not in SNc.

    2. Unbalanced synaptic inputs underlying multi‐peaked frequency selectivity in rat auditory cortex (pages 1078–1084)

      Chang Zhou, Can Tao, Guangwei Zhang, Sumei Yan, Lijuan Wang, Yi Zhou and Ying Xiong

      Version of Record online: 17 MAR 2017 | DOI: 10.1111/ejn.13548

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      A small portion of neurons in the primary auditory cortex of rats showed multi‐peaked frequency selectivity. Similar multi‐peaked frequency selectivity was observed from the excitatory and inhibitory synaptic inputs. Unbalanced excitation and inhibition could enhance the multi‐peaked frequency selectivity.

    3. Synapsins regulate brain‐derived neurotrophic factor‐mediated synaptic potentiation and axon elongation by acting on membrane rafts (pages 1085–1101)

      Hung‐Teh Kao, Kanghyun Ryoo, Albert Lin, Stephen R. Janoschka, George J. Augustine and Barbara Porton

      Version of Record online: 21 MAR 2017 | DOI: 10.1111/ejn.13552

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      We investigated the role of synapsins in neuronal development. The results show that synapsins regulate intracellular membrane raft lipid composition by restricting the ratio of cholesterol to total phospholipids, thereby promoting the localization of Fyn/TrkB to rafts, and subsequent activation of TrkB by BDNF. Consistent with these results, synapsins are required for BDNF‐stimulated axon outgrowth and synaptic potentiation, thus revealing mechanistic links between BDNF and synapsins.


    1. Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleus (pages 1102–1110)

      Jodi R. Paul, Alex S. McKeown, Jennifer A. Davis, Stacie K. Totsch, Eric M. Mintz, Timothy W. Kraft, Rita M. Cowell and Karen L. Gamble

      Version of Record online: 21 MAR 2017 | DOI: 10.1111/ejn.13549

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      Exposure to late‐night light pulse (LP) acutely increases GSK3 activation in the circadian pacemaker – the suprachiasmatic nucleus (SCN), increases SCN neuronal activity 3–5 h later, and advances circadian behavior. Pharmacological inhibition of GSK3 blocks light‐induced SCN activity. Mice with chronically active GSK3 exhibit phase‐advanced behavioral rhythms and SCN excitability.

    2. NF‐κB signalling is involved in immune‐modulation, but not basal functioning, of the mouse suprachiasmatic circadian clock (pages 1111–1123)

      S. M. O'Keeffe, A. L. Beynon, J. S. Davies, P. N. Moynagh and A. N. Coogan

      Version of Record online: 23 MAR 2017 | DOI: 10.1111/ejn.13553

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      The roles of NF‐κB signalling in the suprachiasmatic nucleus circadian clock were examined. We did not find evidence for the involvement of NF‐κB signalling in the basal functioning or photic phase‐resetting of the clock in vivo, or in PER2::LUC rhythms in vitro. NF‐κB components were upregulated in the SCN following immune challenge. Our findings suggest a role for NF‐κB in the suprachiasmatic clock in conditions of immune activation, but not in the basal state.

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FENS Forum

The FENS Forum of Neuroscience is the largest international neuroscience meeting in Europe, involving all neuroscience societies members of FENS, and held biannually on every even year.


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The new EJN Dopamine Special Issue

This special issue celebrates the 90th birthday of Oleh Hornykiewicz by showcasing contributions from participants of the Dopamine 2016 meeting.