Glycogen synthase kinase 3 regulates photic signaling in the suprachiasmatic nucleus (pages 1102–1110)
Jodi R. Paul, Alex S. McKeown, Jennifer A. Davis, Stacie K. Totsch, Eric M. Mintz, Timothy W. Kraft, Rita M. Cowell and Karen L. Gamble
Version of Record online: 21 MAR 2017 | DOI: 10.1111/ejn.13549
Exposure to late‐night light pulse (LP) acutely increases GSK3 activation in the circadian pacemaker – the suprachiasmatic nucleus (SCN), increases SCN neuronal activity 3–5 h later, and advances circadian behavior. Pharmacological inhibition of GSK3 blocks light‐induced SCN activity. Mice with chronically active GSK3 exhibit phase‐advanced behavioral rhythms and SCN excitability.