Connecting European Neuroscience

EJN Table of Content

EJN is the official scientific journal of FENS. Sign-in to the website as a FENS member and enjoy full, free and easy access to all published articles in EJN.

  • Issue Cover

    1. Issue Cover (February 2017) (page i)

      Version of Record online: 12 FEB 2017 | DOI: 10.1111/ejn.13450

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      Cover image by Naoki Ihara, Ai Nakashima, Naosuke Hoshina, Yuji Ikegaya and Haruki Takeuchi

  • REVIEW

    1. Memory under stress: from single systems to network changes (pages 478–489)

      Lars Schwabe

      Version of Record online: 25 NOV 2016 | DOI: 10.1111/ejn.13478

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      Stress has a major impact on the hippocampusand other areas critical for memory. Beyond its effects on single memory systems, stress may also induce large‐scale network reconfigurations that result in a shift from deliberative, thoughtful processing towards more reflexive, habitual responding.

  • MOLECULAR AND SYNAPTIC MECHANISMS

    1. Cotinine administration improves impaired cognition in the mouse model of Fragile X syndrome (pages 490–498)

      Marta Pardo, Eleonore Beurel and Richard S. Jope

      Version of Record online: 12 NOV 2016 | DOI: 10.1111/ejn.13446

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      Stimulation of α7 nicotinic receptors activates PI3K leading to the activating phosphorylations on Akt, which phosphorylates the inhibitory Ser‐9 of GSK3β, leading to pro‐cognitive effects.

    2. Different synaptic stimulation patterns influence the local androgenic and estrogenic neurosteroid availability triggering hippocampal synaptic plasticity in the male rat (pages 499–509)

      Michela Di Mauro, Alessandro Tozzi, Paolo Calabresi, Vito Enrico Pettorossi and Silvarosa Grassi

      Version of Record online: 2 FEB 2017 | DOI: 10.1111/ejn.13455

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      Local synthesizes of E2 and DHT is determinant for the long‐term effects observed in CA1 hippocampus. Finasteride, a blocking agent of DHT synthesis from testosterone (T), prevents the enhancement of the local DHT availability and induces a small LTP instead of LTD in response to LFS. Moreover, letrozole, a blocking agent of E2 synthesis from T, prevents the increase in local E2 availability and remarkably reduces the amplitude of LTP following HFS.

    3. The phosphodiesterase type 2 inhibitor BAY 60‐7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity (pages 510–520)

      Ligia Mendes Soares, Erika Meyer, Humberto Milani, Harry W. M. Steinbusch, Jos Prickaerts and Rúbia M. Weffort de Oliveira

      Version of Record online: 28 NOV 2016 | DOI: 10.1111/ejn.13461

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      Repeated treatment with the PDE2‐I BAY 60‐7550 prevented the functional impairments induced by BCCAO while increasing cAMP/CREB and/or cGMP/CREB signaling.

    4. Sex differences in depolarizing actions of GABAA receptor activation in rat embryonic hypothalamic neurons (pages 521–527)

      Franco R. Mir, Hugo F. Carrer and María J. Cambiasso

      Version of Record online: 25 NOV 2016 | DOI: 10.1111/ejn.13467

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      There are more male than female hypothalamic neurons responding with depolarization to muscimol at 9 days in vitro. In neurons with depolarizing responses, males have larger voltage changes and longer lasting responses than females. These sex differences in GABAAR function are independent of gonadal hormones because hypothalamic tissue has been taken from male and female embryos at E16, two days before neurons would be exposed to gonadal steroids in utero.

    5. Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in pink1/ zebrafish (pages 528–535)

      Smijin Soman, Marcus Keatinge, Mahsa Moein, Marc Da Costa, Heather Mortiboys, Alexander Skupin, Sreedevi Sugunan, Michal Bazala, Jacek Kuznicki and Oliver Bandmann

      Version of Record online: 28 DEC 2016 | DOI: 10.1111/ejn.13473

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      In a pink1−/− zebrafish model of Parkinson's disease, both genetic and pharmacological inhibition of the mitochondrial calcium uniporter (MCU) rescue dopaminergic neurons via normalisation of mitochondrial complex I activity. In contrast, genetic inactivation of the voltage‐dependent anion channel 1 (VDAC1) did not rescue dopaminergic neurons.

    6. Toxic effects of human and rodent variants of alpha‐synuclein in vivo (pages 536–547)

      Natalie Landeck, Kerstin Buck and Deniz Kirik

      Version of Record online: 11 JAN 2017 | DOI: 10.1111/ejn.13493

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      Toxic effects of alpha‐synuclein variants toward nigral dopaminergic neurons was tested in vivo in a dose dependent manner. We demonstrated that vector titers used within the working range result in alpha‐synuclein specific cell death while GFP remains non‐toxic. Furthermore, we could show that all human synucleins have similar toxicity profiles while rat alpha‐synuclein is significantly less toxic.

    7. Different output properties of perisomatic region‐targeting interneurons in the basal amygdala (pages 548–558)

      Boglárka Barsy, Gergely G. Szabó, Tibor Andrási, Attila Vikór and Norbert Hájos

      Version of Record online: 21 JAN 2017 | DOI: 10.1111/ejn.13498

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      GABAergic cells innervating the perisomatic region of principal neurons in cortical areas are in a key position to control circuit operation. Here, we report that parvalbumin‐containing basket cells, axo‐axonic cells and cholecystokinin/type 1 cannabinoid receptor‐expressing basket cells in the amygdalar basal nucleus have distinct passive and active membrane characteristics as well as show differences in synaptic transmission. Our results suggest that these three inhibitory cell types may accomplish specific functions in amygdala operation.

  • NEUROSYSTEMS

    1. Optogenetic excitation in the ventral tegmental area of glutamatergic or cholinergic inputs from the laterodorsal tegmental area drives reward (pages 559–571)

      Stephan Steidl, Huiling Wang, Marco Ordonez, Shiliang Zhang and Marisela Morales

      Version of Record online: 21 NOV 2016 | DOI: 10.1111/ejn.13436

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      We used optogenetic methods in Cre transgenic mice to compare the effects of driving LDTg‐cholinergic or LDTg‐glutamatergic inputs to the VTA. Mice could control VTA light stimulation by entering one chamber of a place preference apparatus. Results indicate that VTA excitation of LDTg‐glutamatergic inputs may be more important for reinforcement of initial chamber entry while VTA excitation of LDTg‐cholinergic inputs may be more important for the rewarding effects of chamber stays.

    2. Castration alters the number and structure of dendritic spines in the male posterodorsal medial amygdala (pages 572–580)

      Mariana Zancan, Aline Dall'Oglio, Edson Quagliotto and Alberto A. Rasia‐Filho

      Version of Record online: 24 NOV 2016 | DOI: 10.1111/ejn.13460

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      Castration promotes a synaptic reorganization in the posterodorsal medial amygdala of male rats; Castration reduces the density of dendritic spines, but is spine‐specific: thin, mushroom‐like, and ramified spines are reduced whereas stubby/wide and atypical spines increase after castration; the lack of androgens hinder the function of integrated circuitries for social behavior in the male brain.

    3. Deficit in acoustic signal‐in‐noise detection in glycine receptor α3 subunit knockout mice (pages 581–586)

      Konstantin Tziridis, Stefanie Buerbank, Volker Eulenburg, Julia Dlugaiczyk and Holger Schulze

      Version of Record online: 18 JAN 2017 | DOI: 10.1111/ejn.13489

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      We found specific changes in the ABR signals and impairment of PPI of the auditory startle response in GlyRα3 KO mice indicating that efferent GlyRα3‐mediated glycinergic inhibition in the cochlea is important for signal‐in‐noise detection.

    4. Possible role of calcitonin gene‐related peptide in trigeminal modulation of glomerular microcircuits of the rodent olfactory bulb (pages 587–600)

      Federica Genovese, Hanke Gwendolyn Bauersachs, Ines Gräßer, Janina Kupke, Laila Magin, Philipp Daiber, Sertel‐Nakajima  , Frank Möhrlen, Karl Messlinger and Stephan Frings

      Version of Record online: 5 JAN 2017 | DOI: 10.1111/ejn.13490

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      Stimulation with irritants impedes the processing of olfactory signals. This paper provides evidence that the olfactory bulb is a site of interaction between the trigeminal and olfactory systems. The ethmoidal branch of the trigeminal system invades the olfactory bulb and innervates 50% of the glomeruli with peptidergic fibers. CGRP released from these fibers inhibits glomerular circuit activity, possibly by targeting pacemaker neurons, the external tufted cells. This neuromodulatory pathway may contribute to chemosensory cross‐talk in rodents.

    5. Binocular function during unequal monocular input (pages 601–609)

      Taekjun Kim and Ralph D. Freeman

      Version of Record online: 25 JAN 2017 | DOI: 10.1111/ejn.13500

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      This paper resolves a conflict between previous psychophysical and neurophysiological data concerning binocular function when image quality between left and right eyes is unequal. We demonstrate via psychophysical tests that there is a basic form of binocular function even when image quality is substantially different for left and right eyes. Panel A of the figure shows a mirror haploscope which is used to present two separate views to each eye. Binocular fusion of two opposite drifting gratings induces a perception of a counter‐phase flickering grating.

    6. Stimulus‐specific adaptation to visual but not auditory motion direction in the barn owl's optic tectum (pages 610–621)

      Dante F. Wasmuht, Jose L. Pena and Yoram Gutfreund

      Version of Record online: 17 JAN 2017 | DOI: 10.1111/ejn.13505

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      In the visual system, a dedicated motion processing pathway has been discovered. Compared to visual motion, little is known about auditory motion processing. Here, we recorded from multisensory neurons in the barn owl's optic tectum to directly compare responses to visual and auditory motion. Our results show a qualitative difference between the representations of auditory vs. visual motion, not supporting the hypothesis that a dedicated motion processing pathway exists in the auditory system.

  • CORRIGENDUM

    1. Stuttering as a trait or a state revisited: motor system involvement in persistent developmental stuttering (pages 622–624)

      Michel Belyk, Shelly Jo Kraft and Steven Brown

      Version of Record online: 12 FEB 2017 | DOI: 10.1111/ejn.13512

      This article corrects:

      Stuttering as a trait or state – an ALE meta‐analysis of neuroimaging studies

      Vol. 41, Issue 2, 275–284, Version of Record online: 28 OCT 2014

    2. Regular theta‐firing neurons in the nucleus incertus during sustained hippocampal activation (page 625)

      David Belin and Thora Karadottir

      Version of Record online: 12 FEB 2017 | DOI: 10.1111/ejn.13513

      This article corrects:

      Writing a constructive peer review: a young PI perspective

      Vol. 44, Issue 11, 2873–2876, Version of Record online: 24 OCT 2016

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FENS Forum

The FENS Forum of Neuroscience is the largest international neuroscience meeting in Europe, involving all neuroscience societies members of FENS, and held biannually on every even year.

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The new EJN Dopamine Special Issue

This special issue celebrates the 90th birthday of Oleh Hornykiewicz by showcasing contributions from participants of the Dopamine 2016 meeting.

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