Mirror trends of plasticity and stability indicators in primate prefrontal cortex (pages 2392–2405)
Miguel Á. García‐Cabezas, Mary Kate P. Joyce, Yohan J. John, Basilis Zikopoulos and Helen Barbas
Version of Record online: 4 OCT 2017 | DOI: 10.1111/ejn.13706
Systematic variation in cortical structure across areas suggests varying levels of plasticity. Here, we show that in prefrontal cortices of adult monkeys, markers related to synaptic plasticity are high in limbic areas, while markers of stability are low; the opposite trend is seen in eulaminate areas, which have greater laminar elaboration than limbic areas. High plasticity markers may render limbic areas flexible for learning and memory but also vulnerable to neurologic and psychiatric diseases.