Possible role of calcitonin gene‐related peptide in trigeminal modulation of glomerular microcircuits of the rodent olfactory bulb (pages 587–600)
Federica Genovese, Hanke Gwendolyn Bauersachs, Ines Gräßer, Janina Kupke, Laila Magin, Philipp Daiber, Sertel‐Nakajima , Frank Möhrlen, Karl Messlinger and Stephan Frings
Version of Record online: 5 JAN 2017 | DOI: 10.1111/ejn.13490
Stimulation with irritants impedes the processing of olfactory signals. This paper provides evidence that the olfactory bulb is a site of interaction between the trigeminal and olfactory systems. The ethmoidal branch of the trigeminal system invades the olfactory bulb and innervates 50% of the glomeruli with peptidergic fibers. CGRP released from these fibers inhibits glomerular circuit activity, possibly by targeting pacemaker neurons, the external tufted cells. This neuromodulatory pathway may contribute to chemosensory cross‐talk in rodents.