MAP6 interacts with Tctex1 and Cav2.2/N‐type calcium channels to regulate calcium signalling in neurons (pages 2754–2767)
Jacques Brocard, Fabrice Dufour, Sylvie Gory‐Fauré, Christophe Arnoult, Christophe Bosc, Eric Denarier, Leticia Peris, Yasmina Saoudi, Michel De Waard and Annie Andrieux
Version of Record online: 22 NOV 2017 | DOI: 10.1111/ejn.13766
In the present study, we demonstrate that MAP6 proteins interact with Tctex1 and Cav2.2/N‐type calcium channel to regulate calcium channels activity in hippocampal neurons. While MAP6‐E or its N‐terminal mutant form (MAP6‐EΔ1) seem sufficient to address Cav2.2 channels properly, mutating the RRRIR motif to AAAIA in addition to deleting its microtubule‐binding motif Mn3 seem to prevent this activity (MAP6‐E ΔMn3AAAIA and MAP6‐EΔ1ΔMn3AAAIA mutants).