Connecting European Neuroscience

EJN Table of Content

EJN is the official scientific journal of FENS. Sign-in to the website as a FENS member and enjoy full, free and easy access to all published articles in EJN.

  • Issue Cover

    1. Issue Cover (August 2017) (page i)

      Version of Record online: 13 AUG 2017 | DOI: 10.1111/ejn.13471

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      Cover image by Dr. Natalie Doig (MRC Brain Network Dynamics Unit, Department of Pharmacology, Oxford). The cover image is of a frontal section of mouse brain showing many regions of the basal ganglia. The section was triple‐immunostained to reveal tyrosine hydroxylase (TH; cyan), parvalbumin (PV; green) and choline acetyltransferase (magenta).

  • TECHNICAL SPOTLIGHT

    1. Everyday memory: towards a translationally effective method of modelling the encoding, forgetting and enhancement of memory (pages 1937–1953)

      Mio Nonaka, Richard Fitzpatrick, Jennifer Lapira, Damian Wheeler, Patrick A. Spooner, Marta Corcoles‐Parada, Mónica Muñoz‐López, Tim Tully, Marco Peters and Richard G. M. Morris

      Version of Record online: 26 JUL 2017 | DOI: 10.1111/ejn.13637

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      Many aspects of everyday memory are remembered for a few hours and then forgotten. Our new animal model of this type of memory requires rats to discriminate between a rewarded and an unrewarded location of food reward in an event arena. We explore neurobiological parameters that determine how long such memories last, including unexpected environmental novelty given after memory encoding, and the impact of a putative cognitive enhancer.

  • CLINICAL AND TRANSLATIONAL NEUROSCIENCE

    1.  

      Commentary on Featured article

      Advance MR imaging in sports‐related concussion and mild traumatic brain injury – ready for clinical use? (Commentary on Tremblay et al. 2017) (pages 1954–1955)

      Sven Haller

      Version of Record online: 1 AUG 2017 | DOI: 10.1111/ejn.13643

    2. Featured Article

      Defining a multimodal signature of remote sports concussions (pages 1956–1967)

      Sébastien Tremblay, Yasser Iturria‐Medina, José María Mateos‐Pérez, Alan C. Evans and Louis De Beaumont

      Version of Record online: 16 MAY 2017 | DOI: 10.1111/ejn.13583

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      By combining biomarkers from cognitive, genetic, white matter and grey matter assessments, we can develop an objective diagnostic tool for a history of sports concussions. White matter integrity emerges as the hallmark of remote concussions.

    3. Does transcranial electrical stimulation enhance corticospinal excitability of the motor cortex in healthy individuals? A systematic review and meta‐analysis (pages 1968–1990)

      Thusharika Dissanayaka, Maryam Zoghi, Michael Farrell, Gary F. Egan and Shapour Jaberzadeh

      Version of Record online: 2 AUG 2017 | DOI: 10.1111/ejn.13640

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      tES has significant effect on corticospinal excitability (CSE) in healthy individuals. Among tES techniques, application of a‐tDCS on non‐dominant side primary motor cortex produces significant effect on CSE. Future studies should focus the effect of tPCS on CSE.

    4. Impaired corticomuscular coherence during isometric elbow flexion contractions in humans with cervical spinal cord injury (pages 1991–2000)

      Sylvain Cremoux, Jessica Tallet, Fabien Dal Maso, Eric Berton and David Amarantini

      Version of Record online: 1 AUG 2017 | DOI: 10.1111/ejn.13641

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      Corticomuscular coherence (CMC) with agonist and antagonist muscles was investigated in participants with SCI and able‐bodied participants performing actual isometric elbow flexion contractions. SCI participants revealed lower CMC and increased muscle co‐activation, which may reflect the decreased cortical influence on inhibitory spinal mechanisms. Clinically, CMC may efficiently evaluate the residual integrity of the neuromuscular system after SCI and the effects of rehabilitation.

    5. Differential activation of neuronal and glial STAT3 in the spinal cord of the SOD1G93A mouse model of amyotrophic lateral sclerosis (pages 2001–2014)

      Tomohiro Ohgomori, Ryo Yamasaki, Hideyuki Takeuchi, Kenji Kadomatsu, Jun‐ichi Kira and Shozo Jinno

      Version of Record online: 8 AUG 2017 | DOI: 10.1111/ejn.13650

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      Activation mechanisms of neuronal and glial STAT3 were investigated using SOD1G93A mice, genetic model of familial ALS, at 9 weeks of age (S9, vs. age‐matched wild‐type controls, W9), IDPN‐treated mice (model of axonopathy, vs. vehicle controls, C) and LPS‐treated mice (model of neuroinflammation, vs. vehicle controls, C). Our results indicate that axonopathy and neuroinflammation may trigger the respective activation of neuronal and glial STAT3, which is observed during ALS pathogenesis.

  • NEUROSYSTEMS

    1. The atypical dopamine receptor agonist SKF 83959 enhances hippocampal and prefrontal cortical neuronal network activity in a rat model of cognitive dysfunction (pages 2015–2025)

      Melissa L. Perreault, Theresa Fan, Tomek J. Banasikowski, Anthony A. Grace and Susan R. George

      Version of Record online: 1 AUG 2017 | DOI: 10.1111/ejn.13635

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      The atypical dopamine agonist SKF 83959 regulates the expression and activity of proteins involved in cognitive function; however, the impact of the drug in learning and memory has not been explored. Using a schizophrenia model, here we show improved neuronal oscillatory synchrony in prefrontal cortex and hippocampus, yet impaired spatial memory and increased anxiety‐like behaviour following SKF 83959. These disparate findings may suggest multiple receptor mechanisms underlie the drug effects.

    2. GPR88 in A2A receptor‐expressing neurons modulates locomotor response to dopamine agonists but not sensorimotor gating (pages 2026–2034)

      A. C. Meirsman, A. de Kerchove d'Exaerde, B. L. Kieffer and A.‐M. Ouagazzal

      Version of Record online: 2 AUG 2017 | DOI: 10.1111/ejn.13646

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      The orphan receptor, Gpr88, is selectively and highly expressed in striatal medium spiny neurons (MSNs). Ablation of Gpr88 in the whole brain increases the sensitivity of mice to locomotor stimulant effects of dopamine agonists and impairs acoustic and visual PPI. Ablation of Gpr88 selectively in A2Areceptor‐expressing MSNs produces similar motor phenotypes but had no effect on PPI indicating that the former receptors play prominent role in psychomotor behaviours.

  • BEHAVIOURAL NEUROSCIENCE

    1. DREADD‐induced silencing of the medial amygdala reduces the preference for male pheromones and the expression of lordosis in estrous female mice (pages 2035–2046)

      Elizabeth A. McCarthy, Arman Maqsudlu, Matthew Bass, Sofia Georghiou, James A. Cherry and Michael J. Baum

      Version of Record online: 1 AUG 2017 | DOI: 10.1111/ejn.13636

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      Vomeronasal–accessory olfactory bulb inputs to the medial amygdala (Me) regulate courtship in female mice. Intraperitoneal injections of the pro‐drug, clozapine‐N‐oxide (CNO, which hyperpolarized infected neurons) over tests 1–5 reduced sexually receptive lordosis behavior in estrous female mice infected in the Me with an inhibitory DREADD. When saline was given on test 6 to females previously treated with CNO, lordosis expression was as high as in females repeatedly given saline over tests 1–5.

    2. Long‐lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign‐tracking (pages 2047–2055)

      Kurt M. Fraser and Patricia H. Janak

      Version of Record online: 1 AUG 2017 | DOI: 10.1111/ejn.13642

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      We examined whether the neural systems regulating Pavlovian cue approach, or sign‐tracking, switch with increased experience. Sign‐tracking is a Pavlovian conditioned response indicative of the attribution of incentive motivational value to reward‐paired cues. We show that sign‐tracking is sensitive to dopamine antagonism in the nucleus accumbens core even with extended experience and also that neither activity nor dopamine in the dorsal lateral striatum is important for this behavior.

    3. Effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine‐induced behavioral sensitization (pages 2056–2066)

      Byeong Jun Kang, Shelly Sooyun Song, Lei Wen, Ki‐Pyo Hong, George J. Augustine and Ja‐Hyun Baik

      Version of Record online: 9 AUG 2017 | DOI: 10.1111/ejn.13648

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      We examined the effect of optogenetic inhibition of dopamine D2 receptors (D2R) expressed in the medium spiny neurons (MSNs) of the nucleus accumbens (NAc) on cocaine‐induced behavioral sensitization. Our results argue that the optogenetic manipulation of D2R‐MSNs does not affect the overall initiation and expression phases of cocaine‐induced behavioral sensitization. Together with more detailed analysis of the effects of optogenetic activation of D2R‐MSNs, potential modulatory role of D2R signaling in the NAc for addictive behavior is discussed.

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