Connecting European Neuroscience

EJN Table of Content

EJN is the official scientific journal of FENS. Sign-in to the website as a FENS member and enjoy full, free and easy access to all published articles in EJN.

  • Issue Cover

    1. Issue Cover (March 2017) (page i)

      Version of Record online: 19 MAR 2017 | DOI: 10.1111/ejn.13452

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      Cover image by Naoki Ihara, Ai Nakashima, Naosuke Hoshina, Yuji Ikegaya and Haruki Takeuchi

  • CLINICAL AND TRANSLATIONAL NEUROSCIENCE

    1.  

      Commentary on Featured article

      Priming the stump in peripheral nerve injury (Commentary on Zhang et al. (2017)) (pages 748–749)

      John C. Elfar

      Version of Record online: 6 FEB 2017 | DOI: 10.1111/ejn.13523

    2. Featured Article

      Transplantation of embryonic spinal cord neurons to the injured distal nerve promotes axonal regeneration after delayed nerve repair (pages 750–762)

      Wenming Zhang, Xinyu Fang, Chaofan Zhang, Wen Li, Wai Man Wong, Yejun Xu, Wutian Wu and Jianhua Lin

      Version of Record online: 23 JAN 2017 | DOI: 10.1111/ejn.13495

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      Embryonic spinal cord neurons, after transplantation into the injured distal nerve stump, could sprout axons, interact with SCs and re‐innervate the target muscles to keep them in the ‘available’ state for the delayed axonal regeneration. After the delayed cross‐suturing surgery, the axon regeneration from the proximal nerve was stronger, and milder muscle atrophy were observed. The transplantation of embryonic spinal cord neurons may be useful as a potential treatment strategy for PNI.

    3. Chronic ghrelin treatment reduced photophobia and anxiety‐like behaviors in nitroglycerin‐ induced migraine: role of pituitary adenylate cyclase‐activating polypeptide (pages 763–772)

      Fereshteh Farajdokht, Shirin Babri, Pouran Karimi, Mohammad Reza Alipour, Ramin Bughchechi and Gisou Mohaddes

      Version of Record online: 4 JAN 2017 | DOI: 10.1111/ejn.13486

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      Chronic intermittent administration of nitroglycerin (NTG) influences trigeminal neurons and activates them to release pituitary adenylate cyclase‐activating polypeptide (PACAP). PACAP induces anxiety‐like behaviors and photophobia. An increased blood level of PACAP also stimulates satellite glial cells to release proinflammatory cytokines, which in turn results in neurogenic inflammation, elevation of WBC, and proliferation of satellite glial cells. Moreover, PACAP increases serum levels of cortisol through activation of the hypothalamus‐pituitary axis, which is associated with hyperglycemia. Chronic ghrelin treatment reverses all changes induced by NTG, possibly through inhibition of PACAP release from trigeminal neurons. Therefore, ghrelin may hold therapeutic capacity in managing the chronic migraine.

    4. In vitro differentiation of neural stem cells derived from human olfactory bulb into dopaminergic‐like neurons (pages 773–784)

      Rafieh Alizadeh, Gholamreza Hassanzadeh, Mohammad Taghi Joghataei, Mansoureh Soleimani, Fatemeh Moradi, Shahram Mohammadpour, Jahangir Ghorbani, Ali Safavi, Maryam Sarbishegi, Vahid Pirhajati Mahabadi, Leila Alizadeh and Mahmoudreza Hadjighassem

      Version of Record online: 1 MAR 2017 | DOI: 10.1111/ejn.13504

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      The human olfactory bulb neural stem cells (OB‐NSCs) could be isolated. OB‐NSCs are capable to differentiate to dopaminergic‐like cells as a promising tool in Parkinson disease therapy.

    5. Muscle atrophy is associated with cervical spinal motoneuron loss in BACHD mouse model for Huntington's disease (pages 785–796)

      Priscila Aparecida Costa Valadão, Bárbara Campos de Aragão, Jéssica Neves Andrade, Matheus Proença S. Magalhães‐Gomes, Giselle Foureaux, Julliane Vasconcelos Joviano‐Santos, José Carlos Nogueira, Fabíola Mara Ribeiro, Juan Carlos Tapia and Cristina Guatimosim

      Version of Record online: 30 JAN 2017 | DOI: 10.1111/ejn.13510

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      Huntington's disease symptoms are caused by changes in cortex and striatum neurons induced by mutated huntingtin. In this study, we investigated the impact of this abnormal protein in the motor unit, the final pathway of the motor system. We observed abnormalities in the cervical spinal cord motoneurons and muscle in a mouse model for Huntington's disease (BACHD). These observations might help to understand neuromuscular changes in Huntington's disease.

  • BEHAVIOURAL NEUROSCIENCE

    1. Transient and persistent behavioral and molecular changes in primiparous female Wistar rats (pages 797–804)

      Roshan R. Naik and Trynke R. de Jong

      Version of Record online: 13 OCT 2016 | DOI: 10.1111/ejn.13411

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      Reduced anxiety and increased maternal responsiveness in mid‐lactation coincided with strongly increased expression of the oxytocin receptor gene (Oxtr) and vasopressin 1A receptor gene (Avpr1a) in the BNST. Anxiety behavior and gene expression patterns were normalized either at weaning (3 weeks after birth) or 4 weeks after weaning, whereas maternal responsiveness remained elevated. These results emphasize the transient nature of lactation‐induced behavioral and molecular adaptations.

    2. Urokinase‐type plasminogen activator modulates mammalian circadian clock phase regulation in tissue‐type plasminogen activator knockout mice (pages 805–815)

      Joanna M. Cooper, Ashutosh Rastogi, Jessica A. Krizo, Eric M. Mintz and Rebecca A. Prosser

      Version of Record online: 9 JAN 2017 | DOI: 10.1111/ejn.13511

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      Tissue‐type plasminogen activator knockout (tPA−/−) mice exhibit normal photic phase resetting but slower than normal reentrainment. In vitro glutamate‐induced circadian clock phase shifting is normal in tPA−/− mice, but it is blocked by a urokinase PA (uPA) inhibitor. tPA and uPA are expressed and enzymatically active in the SCN, but only tPA appears to activate brain derived neurotrophic factor. Proteolytic modulation of circadian clock phase appears to involve multiple signaling pathways.

    3. Disruption of dopamine homeostasis has sexually dimorphic effects on senescence characteristics of Drosophila melanogaster (pages 816–825)

      Andrea Bednářová, Marley E. Hanna, Kuntol Rakshit, Janis M. O'Donnell and Natraj Krishnan

      Version of Record online: 7 FEB 2017 | DOI: 10.1111/ejn.13525

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      Sexually dimorphic effects of disruptions in dopamine (DA) homeostasis and its relationship to senescence were investigated in Drosophila melanogaster. Catsup26 with elevated DA levels, and ple2 and PuZ22 with depleted DA levels showed sex‐specific effects in longevity, activity, senescence, and age‐associated transcription factors. These results reveal a novel sexually dimorphic involvement of DA in senescence characteristics of D. melanogaster.

    4. Food restriction induces synaptic incorporation of calcium‐permeable AMPA receptors in nucleus accumbens (pages 826–836)

      Jiangyong Ouyang, Ioana Carcea, Jennifer K. Schiavo, Kymry T. Jones, Ariana Rabinowitsch, Rhonda Kolaric, Soledad Cabeza de Vaca, Robert C. Froemke and Kenneth D. Carr

      Version of Record online: 15 FEB 2017 | DOI: 10.1111/ejn.13528

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      Increased surface expression and postsynaptic density abundance of GluA1, but not GluA2, in the nucleus accumbens of food‐restricted (FR) relative to ad libitum fed (AL) rats, suggest synaptic insertion of Ca2+‐permeable AMPARs. Electrophysiological support for this conclusion is provided, as are pharmacological results indicating involvement of these AMPARs in the enhanced behavioral response of food‐restricted rats to D‐1, but not D‐2, dopamine receptor stimulation.

    5. Resting state functional connectivity measures correlate with the response to anodal transcranial direct current stimulation (pages 837–845)

      Brenton Hordacre, Bahar Moezzi, Mitchell R. Goldsworthy, Nigel C. Rogasch, Lynton J. Graetz and Michael C. Ridding

      Version of Record online: 18 JAN 2017 | DOI: 10.1111/ejn.13508

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      Connectivity was found to be a strong predictor of the neuroplastic response to tDCS. Greater connectivity in the high beta frequency between C3 and a cluster of electrodes approximately overlying the left parietal cortex was associated with stronger responses to anodal tDCS applied over the left motor cortex. This relationship was not evident for sham tDCS.

    6. Activation of galanin and cholecystokinin receptors in the lumbosacral spinal cord is required for ejaculation in male rats (pages 846–858)

      Natalie Kozyrev and Lique M. Coolen

      Version of Record online: 24 JAN 2017 | DOI: 10.1111/ejn.13515

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      The spinal ejaculation generator is comprised of lumbar spinothalamic (LSt) cells and their axonal projections to autonomic andmotor neurons in the lumbosacral spinal cord. LSt cells express and release several neuropeptides, including galanin and cholecystokinin (CCK). This study demonstrates that galanin and CCK both act in the spinal ejaculation generator to regulate the ejaculatory reflex.

    7. Differences in anatomical connections across distinct areas in the rodent prefrontal cortex (pages 859–873)

      Stacey A. Bedwell, E. Ellen Billett, Jonathan J. Crofts and Chris J. Tinsley

      Version of Record online: 16 FEB 2017 | DOI: 10.1111/ejn.13521

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      Anterograde (Fluoro‐Ruby) and retrograde (Fluoro‐Gold) tracer injections were made into anterior and posterior regions of prefrontal cortex. The resultant labelling in temporal and sensory‐motor cortices revealed clear differences in the organization of connections between anterior and posterior PFC. The key finding is that of increased similarity between retrograde and anterograde projection locations within temporal and sensorimotor cortex following injections into posterior PFC.

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