Connecting European Neuroscience

EJN Table of Content

EJN is the official scientific journal of FENS. Sign-in to the website as a FENS member and enjoy full, free and easy access to all published articles in EJN.

  • Issue Cover

    1. Issue Cover (June 2017) (page i)

      Version of Record online: 18 JUN 2017 | DOI: 10.1111/ejn.13459

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      Cover image by Naoki Ihara, Ai Nakashima, Naosuke Hoshina, Yuji Ikegaya and Haruki Takeuchi


    1. Long‐term progressive motor skill training enhances corticospinal excitability for the ipsilateral hemisphere and motor performance of the untrained hand (pages 1490–1500)

      Lasse Christiansen, Malte Nejst Larsen, Michael James Grey, Jens Bo Nielsen and Jesper Lundbye‐Jensen

      Version of Record online: 13 OCT 2016 | DOI: 10.1111/ejn.13409

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      Six weeks of unimanual progressive visuomotor training increased motor performance of the untrained hand and corticospinal excitability of the untrained hemisphere compared to conventional training. This suggests that compared to conventional training, progressive training creates a motor representation accessible to both the trained and untrained hand. Differences between effects of progressive and conventional motor practice persisted 8 days following the intervention, but not 14 months later in a long‐term retention test. Potential clinical implications are discussed.

    2. The brain‐derived neurotrophic factor Val66Met polymorphism affects encoding of object locations during active navigation (pages 1501–1511)

      Joost Wegman, Anna Tyborowska, Martine Hoogman, Alejandro Arias Vásquez and Gabriele Janzen

      Version of Record online: 14 OCT 2016 | DOI: 10.1111/ejn.13416

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      This fMRI study demonstrates that variations in the BDNF gene affect the encoding of object locations in memory. Met carriers of the BDNF Val66Met polymorphism compared to Val homozygotes activated the left hippocampus more during successful object location memory, pointing to a compensatory mechanism in Met allele carriers.

    3. Reliable estimation of inhibitory efficiency: to anticipate, choose or simply react? (pages 1512–1523)

      Inge Leunissen, Bram B. Zandbelt, Zrinka Potocanac, Stephan P. Swinnen and James P. Coxon

      Version of Record online: 2 JUN 2017 | DOI: 10.1111/ejn.13590

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      Here, we present a series of experiments that directly compare three common stop‐signal paradigms that differ in the distribution of response times. The results show that the widely used choice response (CR) and simple response (SR) time versions of the stop‐signal paradigm are particularly susceptible to skew of the response time distribution and response slowing, and that using the anticipated response (AR) paradigm based on the Slater‐Hammel task offers a viable alternative to obtain more reliable SSRT estimates.

    4. Expertise shapes domain‐specific functional cerebral asymmetry during mental imagery: the case of culinary arts and music (pages 1524–1537)

      Moustafa Bensafi, Arnaud Fournel, Pauline Joussain, Johan Poncelet, Lauranne Przybylski, Catherine Rouby and Barbara Tillmann

      Version of Record online: 1 JUN 2017 | DOI: 10.1111/ejn.13596

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      This study examined mental imagery of experts in culinary arts and in music. Cooks and musicians had, respectively, better olfactory and auditory mental imagery. Whereas asymmetric activity in visual imagery was observed in experts and non‐experts, imagery of smells in cooks, and of sounds in musicians, recruited both hemispheres. These findings highlight how learning and expertise can shape mental representations of sensory attributes of objects through inter‐hemispheric re‐organization.

    5. The control of eye movements by the cerebellar nuclei: polysynaptic projections from the fastigial, interpositus posterior and dentate nuclei to lateral rectus motoneurons in primates (pages 1538–1552)

      Vincent Prevosto, Werner Graf and Gabriella Ugolini

      Version of Record online: 14 MAR 2017 | DOI: 10.1111/ejn.13546

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      We identified cerebellar output channels to abducens motoneurons, using retrograde transneuronal transfer of rabies virus from eye muscles (lateral rectus) in primates. We demonstrated that abducens‐mediated cerebellar eye movement control pathways derive bilaterally from the fastigial nucleus di‐ and trisynaptically, and from the rostral ventrolateral interpositus posterior and caudal dentate trisynaptically.


    1. Immunofluorescence reveals unusual patterns of labelling for connexin43 localized to calbindin‐D28K‐positive interstitial cells in the pineal gland (pages 1553–1569)

      D. D. Tsao, S. G. Wang, B. D. Lynn and J. I. Nagy

      Version of Record online: 11 MAY 2017 | DOI: 10.1111/ejn.13578

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      Intercellular communication mediated by gap junctions supports cell function in most tissues including several neuroendocrine organs. Less is known about the roles of gap junctions in regulating cellular activity in the pineal gland. Here, we show connexin43 localized to calbindin‐positive interstitial cells within perivascular spaces of the pineal, suggesting contributions of connexin43 to gap junctional coupling of these cells.

    2. Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors (pages 1570–1585)

      Ruth T. Betterton, Lisa M. Broad, Krasimira Tsaneva‐Atanasova and Jack R. Mellor

      Version of Record online: 8 MAY 2017 | DOI: 10.1111/ejn.13582

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      In an in vitro and an in silico CA3 hippocampal network, oscillations were induced using theta‐frequency optogenetic stimulation. The power but not the frequency of these oscillations was biphasically regulated by the acetylcholine analogue carbachol in a dose‐dependent manner. Activation of muscarinic M1 acetylcholine receptors (M1 AChR) present on excitatory pyramidal neurons (EN) and not inhibitory interneurons (IN) is necessary and sufficient for this modulation of gamma oscillations.

    3. Neurovascular unit alteration in somatosensory cortex and enhancement of thermal nociception induced by amphetamine involves central AT1 receptor activation (pages 1586–1593)

      Victoria Belén Occhieppo, Natalia Andrea Marchese, Iara Diamela Rodríguez, Osvaldo Martin Basmadjian, Gustavo Baiardi and Claudia Bregonzio

      Version of Record online: 23 MAY 2017 | DOI: 10.1111/ejn.13594

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      AT1‐R are involved in Amphetamine induced neurovascular unit alterations in somatosensory cortex, observed as astrogliosis, increased neuronal apoptosis and vascular network alterations, underlying augmented thermal nociception.

    4. Connexin36 localization to pinealocytes in the pineal gland of mouse and rat (pages 1594–1605)

      S. G. Wang, D. D. Tsao, K. G. Vanderpool, T. Yasumura, J. E. Rash and J. I. Nagy

      Version of Record online: 25 MAY 2017 | DOI: 10.1111/ejn.13602

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      Several neuroendocrine cell types are linked by gap junctions consisting of connexin36, including pancreatic β‐cells, adrenal medullary chromaffin cells and hypothalamic neuroendocrine cells. Here, we show the localization of connexin36‐containing gap junctions to pinealocytes in the pineal of mice and rats. Our results suggest that, as in other neuroendocrine organs, intercellular communication mediated by these gap junctions contribute to the hormone secretory functions of pinealocytes.


    1. Effect of nucleus accumbens lesions on socially motivated behaviour of young domestic chicks (pages 1606–1612)

      Gergely Zachar, András Sebestyén Tóth, Márton Balogh and András Csillag

      Version of Record online: 3 OCT 2016 | DOI: 10.1111/ejn.13402

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      Young domestic chicks with radiofrequency lesions to the nucleus accumbens (Ac), in comparison with control (sham‐operated) birds, emitted more distress calls when tested in isolation in the open field. Yet distress vocalization was suppressed on the presentation of a predatory stimulus, similarly in lesioned and in control chicks. Both groups chose the larger flock (eight) of conspecifics over the smaller one (three). Accumbens lesions may have elicited either decreased fear of exposure to predators or increased craving for conspecifics, suggesting that the likely function of Ac is to modulate goal‐driven, including socially motivated, behaviours, especially when a direct stimulus representing the goal is absent.


    1. Daily oscillation of odorant detection in rat olfactory epithelium (pages 1613–1622)

      Adrien Francois, Vincent Bombail, David Jarriault, Adrien Acquistapace, Denise Grebert, Xavier Grosmaitre and Nicolas Meunier

      Version of Record online: 23 MAY 2017 | DOI: 10.1111/ejn.13600

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      The treatment of odorant information by the olfactory bulb has been shown to oscillate daily, a potential role of its peripheral input has never been considered. In this study, we present the first evidence that odorant detection capacities of the olfactory epithelium follow a nychtemeral rhythm. Our work thus offers a new perspective to study the origin of the olfactory bulb cycling. Furthermore, it emphasises the need to consider daily variation in experimental procedures involving olfaction even when recording at the first step of its processing.


    1. Probabilistic vs. deterministic fiber tracking and the influence of different seed regions to delineate cerebellar‐thalamic fibers in deep brain stimulation (pages 1623–1633)

      Juergen R. Schlaier, Anton L. Beer, Rupert Faltermeier, Claudia Fellner, Kathrin Steib, Max Lange, Mark W. Greenlee, Alexander T. Brawanski and Judith M. Anthofer

      Version of Record online: 2 MAY 2017 | DOI: 10.1111/ejn.13575

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      Probabilistic tracking (green) based on 64 diffusion gradient orientations showed the dentate‐rubro‐thalamic tract (DRTT) along the same path as deterministic tracking with 12 gradient orientations (yellow). However, the probabilistic approach detected the DRTT in more brains than the deterministic approach. Superior to the ventral thalamus the deterministic solution merged with the pyramidal tract, whereas the probabilistic solution diverged into additional tracts such as the ansa lenticularis.

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