Connecting European Neuroscience

EJN Table of Content

EJN is the official scientific journal of FENS. Sign-in to the website as a FENS member and enjoy full, free and easy access to all published articles in EJN.

  • Issue Cover

    1. Issue Cover (October 2017) (page i)

      Version of Record online: 13 OCT 2017 | DOI: 10.1111/ejn.13517

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      Cover image by Dr. Natalie Doig (MRC Brain Network Dynamics Unit, Department of Pharmacology, Oxford). The cover image is of a frontal section of mouse brain showing many regions of the basal ganglia. The section was triple‐immunostained to reveal tyrosine hydroxylase (TH; cyan), parvalbumin (PV; green) and choline acetyltransferase (magenta).


    1. Long‐range cortical dynamics: a perspective from the mouse sensorimotor whisker system (pages 2315–2324)

      Jianguang Ni and Jerry L. Chen

      Version of Record online: 4 OCT 2017 | DOI: 10.1111/ejn.13698

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      Long‐range corticocortical communication has been proposed to enable flexible integration and routing of between brain areas and is believed to be critical for many fundamental cognitive functions during goal‐directed behavior. Here, we summarize recent progress in understanding these interactions from based upon studies on the whisker sensorimotor system of awake behaving mice, focusing on long‐range cortical dynamics between major sensory and motor areas.


    1. The involvement of centralized and distributed processes in sub‐second time interval adaptation: an ERP investigation of apparent motion (pages 2325–2338)

      Utku Kaya, Fazilet Zeynep Yildirim and Hulusi Kafaligonul

      Version of Record online: 28 SEP 2017 | DOI: 10.1111/ejn.13691

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      We examined the effects of sub‐second time interval adaptation on visual apparent motion. Our results showed that both auditory and visual time interval adaptation can alter ERPs elicited by apparent motion. However, the after‐effects by each modality were in the opposite direction and found as distinct changes in the spatiotemporal profile of the neural activity. Accordingly, these findings suggest that distributed sensory processes play an important role in sub‐second time interval adaptation.

    2. Beta‐band oscillations during passive listening to metronome sounds reflect improved timing representation after short‐term musical training in healthy older adults (pages 2339–2354)

      Takako Fujioka and Bernhard Ross

      Version of Record online: 4 OCT 2017 | DOI: 10.1111/ejn.13693

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      After one month of piano training, induced neuromagnetic beta oscillations in older adults exhibited an increased range of modulation during passive listening to metronome beats, accompanied by improved timekeeping ability. Beta changes involved the caudate, auditory, sensorimotor and premotor cortices, parietal lobe, cerebellum and medial prefrontal cortex, suggesting increased resources for timing processing and goal‐oriented monitoring as well as reward‐based sensorimotor learning.

    3. Modulating vicarious tactile perception with transcranial electrical current stimulation (pages 2355–2364)

      Natalie C. Bowling and Michael J. Banissy

      Version of Record online: 13 OCT 2017 | DOI: 10.1111/ejn.13699

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      High‐frequency tRNS targeted at primary somatosensory cortex (SI) was not found to modulate vicarious tactile perception, regardless of the item observed being touched (human hands vs. inanimate objects) or the visual perspective (1st vs. 3rd person). Anodal tDCS targeted at right SI, but not right temporo‐parietal junction (rTPJ), resulted in some modulation of vicarious tactile perception specific to viewing touch to humans vs. dummy hands, although there were limitations to this effect.

    4. Processing of temporally patterned sounds in the auditory cortex of Seba's short‐tailed bat,Carollia perspicillata (pages 2365–2379)

      Lisa M. Martin, Francisco García‐Rosales, M. Jerome Beetz and Julio C. Hechavarría

      Version of Record online: 13 OCT 2017 | DOI: 10.1111/ejn.13702

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      The cortical processing of temporally patterned sounds was investigated in the bat Carollia perspicillata, an animal that produces vocalizations at repetition rates above 50 Hz. We report that specializations for tracking acoustic streams with such fast temporal structure are not present in this bat species. The response of cortical neurons of C. perspicillata resembles that of other mammals that do not need to cope with acoustic sequences containing fast temporal modulations.


    1. Homogeneous processing in the striatal direct and indirect pathways: single body part sensitive type IIb neurons may express either dopamine receptor D1 or D2 (pages 2380–2391)

      Kevin R. Coffey, Miles Nader, Jasmeet Bawa and Mark O. West

      Version of Record online: 4 OCT 2017 | DOI: 10.1111/ejn.13690

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      Somatosensorimotor responsive type IIb neurons, whose activation is specific to single body parts, exist in both the direct and the indirect pathways of the striatum. This provides further evidence that there is homogenous and concurrent activation of the pathways during sensation and movement but is inconsistent with the current ‘competing motor programs’ hypothesis. We suggest an alternate model of the direct and indirect pathways as a differentiator circuit.

    2. Mirror trends of plasticity and stability indicators in primate prefrontal cortex (pages 2392–2405)

      Miguel Á. García‐Cabezas, Mary Kate P. Joyce, Yohan J. John, Basilis Zikopoulos and Helen Barbas

      Version of Record online: 4 OCT 2017 | DOI: 10.1111/ejn.13706

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      Systematic variation in cortical structure across areas suggests varying levels of plasticity. Here, we show that in prefrontal cortices of adult monkeys, markers related to synaptic plasticity are high in limbic areas, while markers of stability are low; the opposite trend is seen in eulaminate areas, which have greater laminar elaboration than limbic areas. High plasticity markers may render limbic areas flexible for learning and memory but also vulnerable to neurologic and psychiatric diseases.

    3. Ipsilateral corticotectal projections from the primary, premotor and supplementary motor cortical areas in adult macaque monkeys: a quantitative anterograde tracing study (pages 2406–2415)

      Michela Fregosi and Eric M. Rouiller

      Version of Record online: 9 OCT 2017 | DOI: 10.1111/ejn.13709

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      The premotor cortex (PM), supplementary motor area (SMA‐proper; but not Pre‐SMA) and primary motor cortex (M1) project to the ipsilateral superior colliculus. The major new finding is that SMA‐proper gives rise to a substantial corticotectal projection. This SMA projection is similar in strength to that of PM and considerably stronger than that originating from M1. The intermediate and deep layers of the superior colliculus are the main targets. There are very rare terminals contralaterally.


    1. Altered Cav1.2 function in the Timothy syndrome mouse model produces ascending serotonergic abnormalities (pages 2416–2425)

      Daniel G. Ehlinger and Kathryn G. Commons

      Version of Record online: 5 OCT 2017 | DOI: 10.1111/ejn.13707

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      The Timothy Syndrome mouse carries a mutation in Cacna1c that encodes Cav1.2 L‐type calcium channels. We reveal enhanced serotonin axon innervation of the dorsal striatum, decreased turnover in the amygdala, and disrupted dorsal raphe serotonin neuron activity/feedback‐inhibition in this model. This represents an important step in understanding serotonin dysfunction in autism, and the impact of Cav1.2 on the serotonin system has important implications for several neuropsychiatric conditions.

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