Connecting European Neuroscience

Post-doctoral position in Bordeaux/France

12 September 2017

Post-doctoral position in Bordeaux/France

Job ID
13855
Place
Bordeaux/France

Description

SCIENTIFIC CONTEXT
The rapid development of wireless communications has raised questions about potential health risks. The only identified biological effects of radiofrequency (RF) fields are caused by heating and the research is now oriented towards the exploration of potential nonthermal biological effects, especially on the CNS, given the proximity between the mobile phone and the brain, and the excitability of neurons. Several human EEG studies have reported variations in the EEG power spectrum during or after RF exposure, suggesting that RF exposure may directly influence brain dynamics. However, the mechanisms underlying these effects on the EEG are still unknown.
EXPERIMENTAL APPROACH
It seems essential to study how the spontaneous electrical activity of neuronal networks in vitro can be affected by RF exposure. Cultures of cortical neurons are grown on MEAs allowing real-time acquisition of their activity. Our experimental bench coupling extracellular electrophysiology and RF exposure is today well controlled and we have already shown a clear decrease in firing and bursting rates of neuronal cultures exposed for 3-min to a GSM RF field [Moretti et al., 2013]; the amplitude of this decrease is dependent on the RF power [El Khoueiry et al., 2017].
POST-DOCTORAL PROJECT
We obtained a grant co-funded by ANSES and Region Nouvelle Aquitaine to now identify the interaction site and mechanism between the neuronal networks and RF fields. Exposure studies will be pursued along with pharmacological tests involving drugs and receptors which can play a role in the observed effect.
We are looking for a young scientist with strong expertise in electrophysiology (recording and data analysis) and a solid background in neuropharmacology. Knowledge and practice in cell biology (primary cell culture) and Matlab (signal processing and data analysis) would be appreciated.The candidate should have the ability to work independently as in collaborative research.

Job Information

Employment start date:
2017-11-01
Contract length:
18 months
Institution:
Bordeaux University
Department:
IMS lab - Bioelectronics Group

Contact Information

Noëlle Lewis
Laboratoire IMS - Université de Bordeaux - bât. A31
351 cours de la Libération
33400 TALENCE
Phone
0540003177
Email
noelle.lewis@u-bordeaux.fr

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