Connecting European Neuroscience

Ph.D. Student in Milton Keynes/UK

06 February 2018

Ph.D. Student in Milton Keynes/UK

Job ID
15083
Place
Milton Keynes/UK

Description

Effective treatment options and long-lasting recovery from substance dependence have been elusive because of the propensity of drug abusers to relapse into drug-seeking and -taking. The reinstatement of these behaviours is often precipitated by re-exposure to conditioned stimuli (CS), or cues, associated with drug use. Importantly, there is considerable individual variation in the degree to which cues exert motivational control over behaviour. Accordingly, the student’s research will address one of the following:

1) Does variation in dopamine neurotransmission and dendritic signalling contribute to how strongly cues motivate behaviour?

2) Can we develop new translational animal models of substance use disorder that reflect how people procure and take drugs, and how variation in these patterns of drug-use impact potential for relapse?

Techniques
• Behavioural investigations in both animals and humans.
• Fast-scan cyclic voltammetry (enables recording of dopamine in animals).
• Dendritic spine analyses (electron and confocal microscopy).
• Optogenetics
• Photometry
• Pharmacology
• Biochemistry

https://singerneurolab.weebly.com/join-us.html

Job Information

Closing date:
2018-02-23
Employment start date:
2018-10-01
Contract length:
3 years
Institution:
The Open University
Department:
Life, Health, and Chemical Sciences

Contact Information

Bryan Singer
Walton Hall, Venables Building

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