Connecting European Neuroscience

Guillermina LÓPEZ-BENDITO

Guillermina López-Bendito undertook her PhD in 2000 under the supervision of Dr. Alfonso Fairén and Rafael Luján at the Institute of Neuroscience, in Alicante (Spain). Then, She worked on the role and precise cellular and subcellular localization of neurotransmitter receptors during pre and postnatal development of the cerebral cortex. Subsequently took up a postdoctoral training in the laboratory of Prof. Zoltán Molnar in the Department of Human Anatomy & Genetics at Oxford University (UK) from 2001-2004. She became interested in the mechanisms involved in the guidance of one of the major axonal tracts in the forebrain, the thalamocortical (TC) projection. She used in vitro culture assays as well as different in vivo tracing studies in a number of mutant mice to study the interaction between TC axons and cerebral cortex. In 2004, she joined the Institute of Neuroscience in Alicante with a Ramón y Cajal semi-independent junior position. Since 2007, she is a full Assistant Professor from the CSIC and a group leader at the Developmental Neurobiology Unit at the same Institute. Her group aims to understand the cellular and molecular mechanisms involved in the guidance of the main axonal tracts of the CNS in mammals. In particular, they are interested in elucidating how one of the most complex axon guidance systems in the mammalian forebrain, the thalamocortical projection, develops.  Dr. López-Bendito got an ERC StG in 2009 and is an EMBO YIP since 2012.

Country of origin: Spain
PhD: University Miguel Hernandez, Alicante, Spain (2000)
Affiliation: Cellular and Molecular Mechanisms of Brain Wiring Lab, Developmental Neurobiology Unit, Instituto de Neurociencias, Spain
http://lopezbenditolab.com
Previous affiliations: Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki, Japan (2005)
  Department of Human Anatomy and Genetics, University of Oxford, UK (2001-2005)

Research interests: Guillermina López-Bendito undertook her PhD in 2000 under the supervision of Dr. Alfonso Fairén and Rafael Luján at the Institute of Neuroscience, in Alicante (Spain). Then, She worked on the role and precise cellular and subcellular localization of neurotransmitter receptors during pre and postnatal development of the cerebral cortex. Subsequently took up a postdoctoral training in the laboratory of Prof. Zoltán Molnar in the Department of Human Anatomy & Genetics at Oxford University (UK) from 2001-2004. She became interested in the mechanisms involved in the guidance of one of the major axonal tracts in the forebrain, the thalamocortical (TC) projection. She used in vitro culture assays as well as different in vivo tracing studies in a number of mutant mice to study the interaction between TC axons and cerebral cortex. In 2004, she joined the Institute of Neuroscience in Alicante with a Ramón y Cajal semi-independent junior position. Since 2007, she is a full Assistant Professor from the CSIC and a group leader at the Developmental Neurobiology Unit at the same Institute. Her group aims to understand the cellular and molecular mechanisms involved in the guidance of the main axonal tracts of the CNS in mammals. In particular, they are interested in elucidating how one of the most complex axon guidance systems in the mammalian forebrain, the thalamocortical projection, develops.  Dr. López-Bendito got an ERC StG in 2009 and is an EMBO YIP since 2012.

Key publications:

1: Garel S, López-Bendito G. Inputs from the thalamocortical system on axon pathfinding mechanisms. Curr Opin Neurobiol. 2014 Aug;27:143-50. doi: 10.1016/j.conb.2014.03.013. Epub 2014 Apr 17. PubMed PMID: 24742382.

2: Leyva-Díaz E, Del Toro D, Menal MJ, Cambray S, Susin R, Tessier-Lavigne M, Klein R, Egea J, López-Bendito G. FLRT3 is a Robo1-interacting protein that determines Netrin-1 attraction in developing axons. Curr Biol. 2014 Mar 3;24(5):494-508. doi: 10.1016/j.cub.2014.01.042. Epub 2014 Feb 20. PubMed PMID: 24560577.

3: Mire E, Mezzera C, Leyva-Díaz E, Paternain AV, Squarzoni P, Bluy L, Castillo-Paterna M, López MJ, Peregrín S, TessierLavigne M, Garel S, Galcerán J, Lerma J, López-Bendito G. Spontaneous activity regulates Robo1 transcription to mediate a switch in thalamocortical axon growth. Nat Neurosci. 2012 Jul 8;15(8):1134-43. doi: 10.1038/nn.3160. PubMed PMID: 22772332.

4: Marcos-Mondéjar P, Peregrín S, Li JY, Carlsson L, Tole S, López-Bendito G. The lhx2 transcription factor controls thalamocortical axonal guidance by specific regulation of robo1 and robo2 receptors. J Neurosci. 2012 Mar 28;32(13):4372-85. doi: 10.1523/JNEUROSCI.5851-11.2012. PubMed PMID: 22457488.

5: Bielle F, Marcos-Mondéjar P, Leyva-Díaz E, Lokmane L, Mire E, Mailhes C, Keita M, García N, Tessier-Lavigne M, Garel S, López-Bendito G. Emergent growth cone responses to combinations of Slit1 and Netrin 1 in thalamocortical axon topography. Curr Biol. 2011 Oct 25;21(20):1748-55. doi: 10.1016/j.cub.2011.09.008. Epub 2011 Oct 13. PubMed PMID: 22000108.

6: López-Bendito G, Sánchez-Alcañiz JA, Pla R*, Borrell V, Picó E, Valdeolmillos M, Marín O. Chemokine signaling controls intracortical migration and final distribution of GABAergic interneurons. J Neurosci. 2008 Feb 13;28(7):1613-24. doi: 10.1523/JNEUROSCI.4651-07.2008. PubMed PMID: 18272682.

7: López-Bendito G, Flames N, Ma L, Fouquet C, Di Meglio T, Chedotal A, Tessier-Lavigne M, Marín O. Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. J Neurosci. 2007 Mar 28;27(13):3395-407. PubMed PMID: 17392456.

8: López-Bendito G, Cautinat A, Sanchez JA, Bielle F, Flames N, Garrat AN, Tagmale D, Role LW, Charnay P, Marin O, Garel S. Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell. 2006 Apr 7;125(1):127-42. PubMed PMID: 16615895; PubMed Central PMCID: PMC2365888.

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