Connecting European Neuroscience

Di Luca, Monica

Member of the Advisory Board (2016-2018)

President (2014 - 2016)

Curriculum Vitae

Professional and academic career

Laurea cum laude in Chemistry and Pharmacology Technology,
Faculty of Pharmacy, University of Milan - 110/110 (1986)
PhD in “Pharmacology”, Faculty of Pharmacy, University of
Milan (1992)
PhD in Medical Sciences, School of Medicine, University of
Utrecht (1993)
Professional experience
Vice-Director, Department Pharmacological Sciences
University of Milano (2003 – present)
Professor of pharmacology - University of Milano (2000 –
present)
Assistant professor, Institute of Pharmacological Sciences
University of Milano (1995 – 2000)

Honors and awards

Award for Neuroscience - Italian Society for Neuroscience
(1997)
Award of the University of Milano for /"Studies on neuronal
plasticity/" (1994)

General administrative and organisational experience

Membership of Scientific boards and committees:
- Chair of Committee for International Research Programmes
  of University of Milano (2012-).
- Chair for International Research Programmes of Italian
  Board of Rectors (2012 -)
- FENS Trust (President: 2006 –)
- European Brain Council (Member of Advisory Board: 2003-
  2006; Vice-president: 2008-present)
- Member of PENS committee (2006-2010)
- IBRO, International Brain Organization (Chair of Western
  Europe Regional Committee: 2006-2010; Chair Inter
  regional activities and member of Executive Committee,
  2010-2014)
- EDAB, (2008 –)
- SfN (Women in Neuroscience Committee: 2007 – 2010,
  Professional Development Committee: 2009 - 2012)
- Italian Interdisciplinary Network on Alzheimer Disease,
  ITINAD (Secretary general: 1998-2001; President: 2001-
  2009)
- SINS – Italian Society of Neurosciences (Board Member:
  2001-2005)

Research interests

Her primary research interest is related to brain and synaptic plasticity both in physiological and pathological conditions, with the primary aim to apply her basic findings to the cure of neurodegenerative diseases as Alzheimer and Parkinson Disease. In the last 15 years she focused on the understanding of the molecular mechanisms regulating the composition, the structural organization and the dynamic of the glutamatergic synapse. In this frame she was coordinator of one European Commission VI FP project (Synscaff) and of two VII FP projects (REPLACES, cPADS) and partner one VII FP project (SYMBAD). A total of 160 pubmed indexed papers have been published.

Selected Publications

  • Malinverno M, Carta M, Epis R, Marcello E, Verpelli C, Cattabeni F, Sala C, Mulle C, Di Luca M, Gardoni F. Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-Cadherin cleavage
    J Neurosci, 2010 Dec 1; 30(48) :16343-55
  • Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, Colombo A, Borroni B, Vara H, Dell'agli M, Cattabeni F, Giustetto M, Borsello T, Forloni G, Padovani A, Di Luca M. Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease. Brain. 2010 Nov; 133(11) :3323-35
  • Gardoni F, Mauceri D, Malinverno M, Polli F, Costa C, Tozzi A, Siliquini S, Picconi B, Cattabeni F, Calabresi P, Di Luca M. Decreased NR2B subunit synaptic levels cause impaired long-term potentiation but not long-term depression. J Neurosci. 2009 Jan 21; 29(3) :669-677
  • Marcello E, Gardoni F, Mauceri D, Romorini S, Jeromin A, Epis R, Borroni B, Cattabeni F, Sala C, Padovani A, Di Luca M. Synapse-associated protein-97 mediates alpha-secretase ADAM 10 trafficking and promotes its activity. J Neurosci. 2007 Feb 14; 27(7) :1682-91
  • Picconi B, Gardoni F, Centonze D, Mauceri D, Cenci MA, Bernardi G, Calabresi P, Di Luca M. Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism. J Neurosci. 2004 Jun 9; 24(23) :5283-91
  • Colciaghi F, Marcello E, Borroni B, Zimmermann M, Caltagirone C, Cattabeni F, Padovani A, Di Luca M. Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease. Neurology. 2004 Feb 10; 62(3) :498-501
  • Gardoni F, Schrama LH, Kamal A, Gispen WH, Cattabeni F, Di Luca M. Hippocampal synaptic plasticity involves competition between Ca2+/calmodulin-dependent protein kinase II and postsynaptic density 95 for binding to the NR2A subunit of the NMDA receptor. J Neurosci. 2001 Mar 1; 21(5) :1501-9

Monica M.G. Di Luca

University of Milano, Pharmacological and Biomolecular Sciences
Via Balzaretti, 9 – 20133 Milano
Italy

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