Connecting European Neuroscience

Fabio Benfenati

Ordinary member, Programme Committee FENS Forum 2016

Curriculum Vitae

Education

1973: Enrico Fermi High School, Bologna (Italy). Degree: Baccalaureate (60/60)

1979: University of Bologna, School of Medicine. Degree: Doctor of Medicine (110/110 cum laude and honorary thesis publication). Field of Study: Neurobiology

1983: University of Bologna, School of Medicine, Postdoctoral School of Neurology. Degree: Specialist in Neurology. Field of Study: Neurophysiology

Current employment

2000-present: Full Professor of Neurophysiology, University of Genova, School of Medicine (Italy)

2006-present: Research Director, Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, Genova (Italy)

Professional and academic career

Academic career

1979: Medical Degree (summa cum laude and best thesis prize), University of Bologna School of Medicine (Italy). Field: neurobiology

1983: Specialist in Neurology (summa cum laude), Neurological Clinic, University of Bologna School of Medicine (Italy). Field: experimental neurophysiology and clinical neurology

1980-1983: "Accademia Nazionale dei Lincei" fellow at the "Mario Negri" Institute for Pharmacological Research (Milano) 1983-1991: Assistant Professor at the Institute of Physiology, University of Modena (Italy)

1983-1984: Post-doctoral fellow at the Department of Histology and Neurobiology at the Karolinska Institutet, Stockholm (Sweden) in Kjell Fuxe's and Thomas Hokfelt's laboratories

1986-1989 Fogarty Fellow & Research Associate, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York (USA) directed by Professor Paul Greengard (Nobel Laureate in 2000)

1990-1995: Guest Investigator, The Rockefeller University, New York (USA)

1992-2000: Associate Professor of Physiology, University of Roma Tor Vergata, School of Medicine (Italy)

1996-present: Member of the Adjunct Faculty, The Rockefeller University, New York (USA)

2000-present: Full Professor of Neurophysiology, University of Genova, School of Medicine (Italy)

2006-present: Research Director, Department of Neuroscience and Brain Technologies, The Italian Institute of Technology, Genova (Italy)

Honours and awards

1979: "Thesis Prize" and thesis publication by the University of Bologna

1980: "Giuseppe Levi" Foundation, Accademia Nazionale dei Lincei, Prize for Neurobiology

1981-1982: “Anna Villa Rusconi” Foundation Fellowship

1986-1987: Fogarty International Center Fellowship from the US Public Health Service

1988: “Italian Society for Neuroscience” Prize for young neuroscientists

1997: Fullbright Advanced Research and University Lecturing Award

2000: Research Award from the Foundation of the Fisher Center for Alzheimer's Disease Research, NY, USA

2012: Foreign Scientist Award, The Michael Stern Foundation for Parkinson's Disease, USA

2013: CURE Innovator Award by the US CURE Foundation.

2013: Smart Cup Absolute Prize and Italian Innovator Award (PNI) in Life Sciences for the artificial retina project ON-IRIS.

 

General administrative and organisational experience

1992-1996: Board Member of the Italian Society for Neuroscience

2003-2005: President, Italian Society for Neuroscience

2004-2006: Board Member of the Italian Federation for Life Sciences (FISV)

2005-2008: Vice-President, National Institute for Neuroscience

2008-2011: Chairman of the IBRO International Program Committee, 8th World Congress of the International Brain Research Organization, Florence (Italy) July 14-19, 2011.

2009-2011: President, The Italian Physiological Society

2010-present: Member of the International Scientific Council of EBRI (European Brain Research Institute, Roma)

2005-present: Member of the Scientific Committee of the International Genoa Science Festival

2009-present: Member of the “CNRS Conseil Scientifique du Departement Sciences du Vivant” (France)

2012-present: President, Italian Collegium of Physiologists

2012-present: President, Advisory Board of the Clinical Res. Institute of Neurological Sciences, Bologna (Italy)

 

Research interests

I have addressed the mechanisms of neural and synaptic communication using a variety of experimental models of human diseases, providing the following main contributions: (i) Elucidation of the mechanisms of neurotransmitter release, synaptic vesicle trafficking and synaptic plasticity and identification of the proteins involved. A long array of papers has, for the first time, put forward the functional role of synaptic vesicle proteins in the regulation of the multi-step process of neurotransmitter release; (ii) Composition of the molecular machine that promotes membrane fusion during exocytosis and identification of the intracellular targets of tetanus/botulinum neurotoxins; (iii) Pathogenic mechanisms of synaptopathies in genetically altered mice lacking synaptic vesicle proteins as models of human neurological disorders such as epilepsy and autism; (iv) Generation of engineered neuronal networks, neuro-electronic and optoneural interfaces by exploiting optogenetics and photovoltaic interfaces. My double background of neurologist and cellular neurophysiologist allowed me to get in depth into the cellular mechanisms that underlie normal brain function and whose dysfunction leads to the pathogenesis of neurological diseases.

- Author of >230 research papers in peer-reviewed international journals, including: Science (1), Nature (2), Neuron (2), Nature Comm. (3), Nature Neuroscience (1), J. Cell Biology (5), J. Clin. Invest. (2), EMBO J. (2), Proc. Natl. Acad. Sci. USA (11), J. Neuroscience (12);

- H-index=56; over 12000 citations; total impact factor > 1000; peer-reviewed papers since 2010: 68

- Co-inventor of 5 patents in the field of neurotechnologies

- Supervisor of >80 students for Bachelor/Master Thesis in the Courses of Medicine, Biological Sciences, Bioengineering and Biotechnologies and over 25 PhD students and participated in several PhD thesis Committees in Universities in France, Belgium, Norway and Sweden.

 

Selected Publications (2012-2014)

  • Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V. (2014) Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors. Stem Cell Reports. 2014 Dec 30. [Epub ahead of print]
  • Gill I, Droubi S, Giovedi S, Fedder K, Bury LA, Bosco F, Sceniak MP, Benfenati F, Sabo SL (2014). Presynaptic NMDA receptors: dynamics and distribution in developing axons in vitro and in vivo. J. Cell Sci. Dec 19. pii: jcs.162362. [Epub ahead of print] PubMed PMID: 25526735.
  • Antognazza MR, Martino N, Ghezzi D, Feyen P, Colombo E, Endeman D, Benfenati F, Lanzani G (2014) Shedding light on living cells. Adv. Mater. 2014 Dec 2.doi:10.1002/adma.201403513. [Epub ahead of print] PubMed PMID: 25469452.
  • Orlando M, Lignani G, Maragliano L, Fassio A, Onofri F, Baldelli P, Giovedí S, Benfenati F (2014). Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics. J. Neurosci. 34:14752-14768.
  • Medrihan L, Ferrea E, Greco B, Baldelli P, Benfenati F (2014) Asynchronous GABA release is a key determinant of tonic inhibition and controls neuronal excitability: a study in the Synapsin II-/- mouse. Cereb. Cortex 2014 Jun 24. pii: bhu141. [Epub ahead of print]
  • Dell'Anno MT, Caiazzo M, Leo D, Dvoretskova E, Medrihan L, Colasante G, Giannelli S, Theka I, Russo G, Mus L, Pezzoli G, Gainetdinov RR, Benfenati F, Taverna S, Dityatev A, Broccoli V (2014) Remote control of induced dopaminergic neurons in parkinsonian rats. J. Clin. Invest. 124: 3215-3229.
  • Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, Kneussel M, Barberis A (2014) Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP. Nature Commun. 5:3921.
  • Verstegen AM, Tagliatti E, Lignani G, Marte A, Stolero T, Atias M, Corradi A, Valtorta F, Gitler D, Onofri F, Fassio A, Benfenati F (2014) Phosphorylation of synapsin I by cyclin-dependent kinase-5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses. J. Neurosci. 34: 7266-7280.
  • Falace A, Buhler E, Fadda M, Watrin F, Lippiello P, Pallesi-Pocachard E, Baldelli P, Benfenati F, Zara F, Represa A, Fassio A, Cardoso C (2014). TBC1D24 regulates neuronal migration and maturation through modulation of the ARF6-dependent pathway. Proc. Natl. Acad. Sci. USA 111: 2337-2342.
  • Corradi A, Fadda M, Piton A, Patry L, Marte A, Rossi P, Cadieux-Dion M, Gauthier J, Lapointe L, Mottron L, Valtorta F, Rouleau GA, Fassio A, Benfenati F*, Cossette P* (2014) SYN2 is an autism predisposing gene: loss-of-function mutations alter synaptic vesicle cycling and axon outgrowth. Hum Mol. Genet. 23: 90-103. *FB: co-last author
  • Pozzi D, Lignani G, Ferrea E, Contestabile A, Paonessa F, D’Alessandro R, Lippiello P, Boido D, Fassio A, Meldolesi J, Valtorta F, Benfenati F, Baldelli P (2013) REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability. EMBO J. 32: 2994-3007.
  • Ghezzi D, Antognazza MR, Maccarone R, Bellani S, Lanzarini E, Martino N, Mete M, Pertile G, Bisti S, Lanzani G, Benfenati F (2013) A polymer optoelectronic interface restores light sensitivity in blind rat retinas. Nature Photonics 7:407-412.
  • Medrihan L, Cesca F,Raimondi A, Lignani G, Baldelli P, Benfenati F (2013) Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by a functional interaction with presynaptic Ca2+ channels. Nature Commun. 4:1512.
  • Lignani G, Ferrea E, Difato F, Amarù J, Ferroni E, Lugarà E, Espinoza S, Gainetdinov RR, Baldelli P, Benfenati F (2013) Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity. Front Mol Neurosci. 6:22.
  • Paonessa F, Latifi S, Scarongella H, Cesca F*, Benfenati F* (2013) Specificity protein 1 (Sp1)-dependent activation of the synapsin I gene (SYN1) is modulated by RE1-silencing transcription factor (REST) and 5'-cytosine-phosphoguanine (CpG) methylation. J Biol Chem. 288: 3227-3239.
  • Lignani G, Raimondi A, Ferrea E, Rocchi A, Paonessa F, Cesca F, Orlando M, Tkatch T, Valtorta F, Cossette P, Baldelli P, Benfenati F (2013) Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity. Hum Mol Genet. 22: 2186-2199.
  • Toader O, Forte N, Orlando M, Ferrea E, Raimondi A, Baldelli P, Benfenati F, Medrihan L (2013). Dentate gyrus network dysfunctions precede the symptomatic phase in a genetic mouse model of seizures. Front. Cell Neurosci. 7:138.
  • Limongi T, Cesca F, Gentile F, Marotta R, Ruffilli R, Barberis A, Dal Maschio M, Petrini EM, Santoriello S, Benfenati F*, Di Fabrizio E* (2013) Nanostructured superhydrophobic substrates trigger the development of 3D neuronal networks. Small 9: 402-412. *FB: co-last author
  • Contestabile A, Greco B, Ghezzi D, Tucci V, Benfenati F, Gasparini L (2013). Lithium rescues synaptic plasticity and memory in Down syndrome mice. J. Clin. Invest. 123: 348-361.
  • Greco B, Managò F, Tucci V, Kao HT, Valtorta F, Benfenati F (2013). Autism-related behavioral abnormalities in synapsin knockout mice. Behav. Brain Res. 251: 65-74.
  • Milh M, Falace A, Villeneuve N, Vanni N, Cacciagli P, Assereto S, Nabbout R, Benfenati F, Zara F, Chabrol B, Villard L, Fassio A (2013). Novel compound heterozygous mutations in TBC1D24 cause familial malignant migrating partial seizures of infancy. Hum. Mutat. 34: 869-872.
  • Bragina L, Fattorini G, Giovedì S, Bosco F, Benfenati F, Conti F (2013). Heterogeneity of presynaptic proteins: do not forget isoforms. Front. Cell Neurosci. 7: 8.
  • Lignani G, Ferrea E, Difato F, Amarù J, Ferroni E, Lugarà E, Espinoza S, Gainetdinov RR, Baldelli P, Benfenati F (2013). Long-term optical stimulation of channelrhodopsin-expressing neurons to study network plasticity. Front. Mol. Neurosci. 6: 22.
  • De Faveri S, Maggiolini E, Miele E, De Angelis F, Cesca F, Benfenati F*, Fadiga L* (2013). Bio-inspired hybrid microelectrodes: a hybrid solution to improve long-term performance of chronic intracortical implants. Front Neuroeng. 7: 7. *FB: co-last author
  • Giannandrea M, Guarnieri FC, Gehring NH, Monzani E, Benfenati F, Kulozik AE, Valtorta F (2013). Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356X mutation in synapsin I. PLoS One 8: e67724.
  • Farisello P, Boido D, Nieus T, Medrihan L, Cesca F, Valtorta F, Baldelli P, Benfenati F (2013) Synaptic and extrasynaptic origin of the excitation/inhibition imbalance in the hippocampus of Synapsin I/II/III knockout mice. Cereb. Cortex 23: 581-593.
  • Gelsomino G, Menna E, Antonucci F, Rodighiero S, Riganti L, Mulle C, Benfenati F, Valtorta F, Verderio C, Matteoli M (2013). Kainate induces mobilization of  synaptic vesicles at the growth cone through the activation of protein kinase A. Cereb. Cortex 23: 531-541.
  • Nazzaro C, Greco B, Cerovic M, Baxter P, Rubino T, Trusel M, Tkatch T, Benfenati F, Pedarzani P, Tonini R (2012). In vivo modulation of SK channels rescues striatal synaptic plasticity and habitual control in cannabinoid dependence. Nature Neurosci. 15: 284-293.
  • Iurilli G, Ghezzi D, Olcese U, Lassi G, Nazzaro C, Tonini R, Tucci V, Benfenati F, Medini P (2012) Sound-driven synaptic inhibition in primary visual cortex. Neuron 73: 814-828.
  • Ferrea E, Maccione A, Medrihan L, Nieus T, Ghezzi D, Baldelli P, Benfenati F, Berdondini L (2012). Large-scale, high-resolution electrophysiological imaging of field  potentials in brain slices with microelectronic multielectrode arrays. Front. Neural Circuits 6: 80.
  • Zullo L, Chiappalone M, Martinoia S, Benfenati F (2012). A "spike-based" grammar underlies directional modification in network connectivity: effect on bursting activity and implications for bio-hybrids systems. PLoS One 7: e49299.
  • Fornasiero EF, Raimondi A, Guarnieri FC, Orlando M, Fesce R, Benfenati F, Valtorta F (2012). Synapsins contribute to the dynamic spatial organization of synaptic  vesicles in an activity-dependent manner. J. Neurosci. 32:12214-12227.
  • Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Bréchot P, Trebak M, Checler F, Benfenati F, Chami M (2012). Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease. J. Neurosci. 32: 11820-11834.
  • Valente P, Casagrande S, Nieus T, Verstegen AM, Valtorta F, Benfenati F, Baldelli P (2012). Site-specific synapsin I phosphorylation participates in the expression of post-tetanic potentiation and its enhancement by BDNF. J. Neurosci. 32: 5868-5879.
  • Neubrand VE, Cesca F, Benfenati F, Schiavo G (2012). Kidins220/ARMS as a functional mediator of multiple receptor signalling pathways. J. Cell Sci. 125: 1845-1854.
  • Marconi E, Nieus T, Maccione A, Valente P, Simi A, Messa M, Dante S, Baldelli P, Berdondini L, Benfenati F (2012). Emergent functional properties of neuronal networks with controlled topology. PLoS One 7: e34648. FB: last author & corresponder
  • Succol F, Fiumelli H, Benfenati F, Cancedda L, Barberis A (2012) Intracellular chloride concentration influences the GABAA receptor subunit composition. Nature Commun. 3: 738.

 

Other selected publications

- Benfenati F., Bähler M., Brunner J., Greengard P. Electrostatic and hydrophobic interactions of synapsin I with phospholipid vesicles. J. Cell Biol. 108: 1851-1862, 1989.

- Benfenati F., Bähler M., Jahn R., Greengard P. Interaction of synapsin I with small synaptic vesicles: distinct sites in synapsin I bind to vesicle phospholipids and vesicle proteins.  J. Cell Biol. 108: 1863-1872, 1989.

- De Camilli P., Benfenati F., Valtorta F., Greengard P. The synapsins. Annu. Rev. Cell Biol. 6: 433-460, 1990.

- Benfenati F., Valtorta F., Greengard P. Computer modeling of synapsin I binding to synaptic vesicles and F-actin: implications for the regulation of neurotransmitter release. Proc. Natl. Acad. Sci. USA 88: 575-579, 1991.

- Benfenati F., Valtorta F., Chieregatti E., Greengard P. Interaction of free and synaptic vesicle-bound synapsin I with F-actin. Neuron, 8: 377-386, 1992.

- Benfenati F., Valtorta F., Rubenstein J.L., Gorelick F., Greengard P., Czernik A.J. Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I. Nature 359: 417-420, 1992.

- Schiavo G., Benfenati F., Poulain B., Rossetto O., Polverino de Laurato P., DasGupta B. R., Montecucco C. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin-2. Nature, 359: 832-835, 1992.

- Greengard P., Valtorta F., Czernik A. J., Benfenati F. Synaptic vesicle phosphoproteins and regulation of synaptic function. Science, 259: 780-785, 1993.

- Benfenati F., Valtorta F., Rossi M.C., Onofri F., Sihra T., Greengard P. Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of bilayer structures. J. Cell Biol., 123: 1845-1855, 1993.

- Jovanovic J., Benfenati F., Siow Y.L., Sihra T.S., Sanghera J.S., Pelech S.L., Greengard P., Czernik A.J. Neurotrophins stimulate phosphorylation of synapsin I by MAP kinase and regulate synapsin I-actin interactions. Proc. Natl. Acad. Sci. USA, 93: 3679-3683, 1996.

- Onofri F., Giovedì S., Vaccaro P., Czernik A.J., Valtorta F., De Camilli P., Greengard P., Benfenati F. Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity. Proc. Natl. Acad. Sci. USA 94: 12168-12173, 1997.

- Kao H-T., Porton B., Czernik A.J., Feng J., Yiu G., Haring M., Benfenati F., Greengard P. A third member of the synapsin gene family. Proc. Natl. Acad. Sci. USA 95: 4667-4672, 1998.

- Jaffrey S.R., Benfenati F., Snowman A.M., Czernik A.J., Snyder S.H. Neuronal nitric oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Proc. Natl. Acad. Sci. USA, 99: 3199-3204, 2002.

- Schenk U., Verderio C., Benfenati F., Matteoli M. Regulated delivery of AMPA receptor subunits to the presynaptic membrane. EMBO J., 22: 558-568, 2003.

- Guo J., Wenk M.R., Pellegrini L., Onofri F., Benfenati F., De Camilli P. Phosphatidylinositol 4-kinase type IIa is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles. Proc.Natl.Acad.Sci.USA, 100, 3995-4000, 2003.

- Hilfiker S., Benfenati F., Doussau F., Nairn A.C., Czernik A.J., Augustine G.J., Greengard P. Structural domains involved in the regulation of transmitter release by synapsins.  J. Neurosci. 25: 2658 - 2669, 2005.

- Bonanomi D., Menegon A., Miccio A., Ferrari G., Corradi A., Kao H-T., Benfenati F., Valtorta F. Phosphorylation of Synapsin I by cyclic AMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons. J. Neurosci., 25: 7299-7308, 2005.

- Menegon A., Bonanomi D., Albertinazzi C., Lotti F., Ferrari G., Kao H-T., Benfenati F., Baldelli P., Valtorta F. Protein kinase A-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activity. J. Neurosci., 26: 11670-11681, 2006
- Fassio A., Merlo D., Mapelli J., Menegon A., Corradi A., Mete M., Zappettini S., Bonanno G., Valtorta F., D'Angelo E., Benfenati F. The synapsin domain E accelerates the exo-endocytotic cycle of synaptic vesicles in cerebellar Purkinje cells. J. Cell Sci., 119: 4257-4268, 2006.

- Baldelli P., Fassio A., Valtorta F., Benfenati F. Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses. J. Neurosci.  27:13520-13531, 2007.

- Corradi A., Zanardi A., Giacomini C., Onofri F., Valtorta F., Zoli M., Benfenati F. Synapsin I and synapsin II null mice display an increased age-dependent cognitive impairment. J. Cell Sci., 121: 3042-3051, 2008.

- Chiappalone M., Casagrande S. Tedesco M., Valtorta F., Baldelli P., Martinoia S., Benfenati F. Opposite changes in glutamatergic and GABAergic transmission underlie the diffuse hyperexcitability of Synapsin I-deficient cortical networks. Cerebral Cortex, 19: 1422-1439, 2009.

- Cesca F, Baldelli P, Valtorta F, Benfenati F (2010) The Synapsins: Key Actors of Synapse Function and Plasticity. Prog. Neurobiol., 91:313-348.

- Ghezzi D, Antognazza MR, Dal Maschio M, Lanzarini E, Benfenati F*, Lanzani G* (2011). A hybrid bioorganic interface for neuronal photoactivation. Nature Comm. 2:166. News&Views in Nature Photonics 5: 138, 2011. *FB: co-last author.

- Cesca F, Yabe A, Spencer-Dene B, Scholz-Starke J, Medrihan L, Maden CH, Gerhardt H, Orriss IR, Baldelli P, Al-Qatari M, Koltzenburg M, Adams RH, Benfenati F*, Schiavo G* (2011) Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ. (Nature Publ. Group) 19:194-208. *FB: co-last author

- Blau A, Murr A, Wolff S, Sernagor E, Medini P, Iurilli G, Ziegler C, Benfenati F (2011) Flexible, all-polymer microelectrode arrays for the capture of cardiac and neuronal signals. Biomaterials 32: 1778-1786. FB: last author & corresponder

- Fassio A, Patry L, Congia S, Onofri F, Piton A, Gauthier J, Pozzi D, Messa M, Defranchi E, Fadda M, Corradi A, Baldelli P, Lapointe L, St-Onge J, Meloche C, Mottron L, Valtorta F, Khoa Nguyen D, Rouleau GA, Benfenati F*, Cossette P* (2011) SYN1 loss-of-function mutations in autism and partial epilepsy cause impaired synaptic function. Hum. Mol. Genet. 20: 2297-2307. *FB: co-last author & corresponder.

- Wang S, Cesca F, Loers G, Schweizer M, Buck F, Benfenati F, Schachner M,Kleene R (2011). Synapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes. J. Neurosci. 31: 7275-7290.

- Perlini LE, Botti F, Fornasiero EF, Giannandrea M, Bonanomi D, Amendola M, Naldini L, Benfenati F, Valtorta F (2011). Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I. J. Cell Sci. 124: 3643-3653.

- Krabben L, Fassio A, Bhatia VK, Pechstein A, Onofri F, Fadda M, Messa M, Rao Y, Shupliakov O, Stamou D, Benfenati F, Haucke V (2011). Synapsin I senses membrane curvature by an amphipathic lipid packing sensor motif. J. Neurosci. 31: 18149-18154.

 

Patent Applications

 

- PCT/IB2009/050751. “POLY-MEA: Microelectrode array based on optically transparent conductive polymer materials and a method of fabrication thereof” Inventors: A Blau, F Benfenati.

- PCT/IB2012/057280. “Sistema integrato di microscopia a forza ottica e a forza atomica“ Inventors: F

Difato, B Torre, A Diaspro, F Benfenati, R Cingolani.

- ITTO2012A000331. “Novel methods of 3D neuronal cell culture using superhydrophobic substrates” Inventors: E Di Fabrizio, T Limongi, F Gentile, R Marotta, F Benfenati, F Cesca.

- PCT/IB2012/052327(E0085129); Publication date 15/5/2012: “Catto-electrode Electroporation Device” Inventors: L Cancedda, GM Ratto, F Benfenati.

- US 13/351046 (publication date 16/1/2012). “A hybrid bioorganic interface for neuronal photoactivation” Inventors: MR Antognazza, D Ghezzi, M Dal Maschio, E Lanzarini, G Lanzani, F Benfenati.

- TO2013A000665. “Organic device for photoinhibition of excitable cells" Inventors: MR Antognazza, D Ghezzi, G Lanzani, G Pertile, M Mete, F Benfenati.

 

Fabio Benfenati, MD

ISTITUTO ITALIANO DI TECNOLOGIA
DEPARTMENT OF NEUROSCIENCE AND BRAIN TECHNOLOGIES
Via Morego 30 - 16163 GENOVA (ITALY)
Phone: +39 01071781434
Fax: +39 01071781230
E-mail: fabio.benfenati@iit.it

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