Connecting European Neuroscience

Panayiota Poirazi

Programme Committee Member FENS Forum 2018

Curriculum Vitae

Education

• Bachelor in Mathematics (honors), University of Cyprus, 1996

• MSc in Biomedical Engineering (honors), University of Southern California, 1998

• PhD in Biomedical Engineering (honors), University of Southern California, 2000 Employment

• IMBB-FORTH: Research Director (since Dec. 2013. Tenured: 2008, First appointed: 2004)

• Visiting Assistant Professor, UCLA & USC, Los Angeles, California (Jan. 2008 – Aug. 2008)

• IMBB-FORTH: Marie Curie Fellow (2002-2004) • BSRC “Al. Fleming”, Athens, Greece: Postdoctoral Fellow (2001-2002) Other professional appointments

• Charité – Universitätsmedizin Berlin, Cluster of Excellence NeuroCure Visiting Fellow (April 2016-present)

• FENS Kavli Network of Excellence: Chair (July 2015-Jan. 2017) Editorial duties

• Section and Associate Editor, Journal of European Neuroscience

• Guest Associate Editor, Frontiers in Bioinformatics and Computational Biology. 

Honours and awards

More than 55 invited talks in top meetings/Institutes world-wide

• Young Academy of Europe, member (2015)

• FENS Kavli Network of Excellence, scholar (2015) & Chair (2015-2017)

• Young Scientist/ERC Ambassador, World Economic Forum, AMNC (2014 & 2015, China)

• Manolis Christofidis Young Investigator Award (by the Cyprus President, 2014)

• Member AcademiaNET - Expert Database of Outstanding Female Scientists and Scholars (2013)

• European Research Council Starting Grant (2012-2017)

• Marie Curie Individual Outgoing Fellowship (2008-2010)

• EMBO Short Term Fellowship, UCLA (2008)

• EMBO Young Investigator Award (2005-2008)

• Marie Curie Individual Fellowship (2002-2004)

• Fred S. Grodins’ Graduate Research Award, University of Southern California (2000)

• Myronis Fellowship for graduate studies at USC (1996-2000)

• Levendis Foundation Grant for graduate studies, academic excellence (1996-2000)

• Academic excellence awards, University of Cyprus (1993-1996). 

General administrative and organisational experience

Chair: FENS Kavli Network of Excellence (2015-2017)

Member: Scientific Council of IMBB-FORTH (2016-2018)

Organizing Committees:

• EMBO Workshop on DENDRITES 2016, (Chair), FORTH, Crete.

• AREADNE international conferences 2010, 2012, 2014 & 2016, Santorini, Greece.

• COSYNE 2015 Workshop on Synapse Clustering (Chair), Utah, U. S.

• DENDRITES 2014 international meeting, (Chair), FORTH, Crete.

• NAMASEN Workshop on Computational Modeling, 2013, Sheffield, UK. 

• NAMASEN Workshop on Computational Modeling, 2013, Sheffield, UK.

• HSCBB 2012 (Local Chair), 7th Annual Conf. of the Hellenic Society for Comp. Biol. and Bioinformatics, Crete.

• ITAB 2009 (Track chair), 9th Int. Conf. on Info. Technol. and Applications in Biomedicine, 2009, Larnaca, Cyprus.

• HSCBB 2006, 1st Cretan Bioinformatics Forum, Heraklion, Crete.

• HSN 2006, 20th Annual Meeting of the Hellenic Society for Neuroscience, Heraklion, Crete.

• ‘Modeling the Brain’s Labyrinth’. 10th year anniversary meeting for the EU course in computational neuroscience, 2006, Crete (Local Chair). 

Research interests

In my lab we develop and utilize computational models and tools to investigate the role of dendrites in learning and memory. I am particularly interested in understanding how dendrites and their integrative properties contribute to different learning and memory functions. Towards this goal, my team and I build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC, V1) and abstraction levels (single neurons, microcircuits, large scale neuronal networks). We then use these models to study how the anatomical, biophysical and plasticity properties of dendrites contribute to functions such as associative learning, working memory, pattern recognition/separation and orientation tuning. We work in close collaboration with experimental labs that provide data for constraining the models and subsequently test certain experimental predictions. 

Selected publications

1. Kastellakis G., Silva, A. J. and Poirazi. P. “Liking memories across time via synapse clustering in nonlinear dendrites” Cell Reports (on the cover), November 1st 2016.

2. Kastelakis G., Cai, D, Mednick, S., Silva A. J and Poirazi P., “Synaptic clustering within dendrites: an emerging theory of memory formation. ” Progress in Neurobiology, 126, 19-35, March 2015. doi: 10.106/j. pneurobio. 2014.12.002

3. Petrantonakis P. and Poirazi P., “A compressed sensing perspective of Hippocampal function. ” Front Syst Neurosci. 2014 Aug 8; 8:141. doi: 10.3389/fnsys. 2014.00141. eCollection 2014.

4. Papoutsi, A., Sidiropoulou, K., and Poirazi, P. “Dendritic nonlinearities reduce size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model. ” PLoS Comput Biol. Jul 31; 10(7) :e1003764. doi: 10.1371/journal. pcbi. 1003764, 2014.

5. Sidiropoulou, K. and Poirazi, P. “Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons” PLoS Comp. Biol, 2012 April; 8(4) : e1002489. doi:10.1371/journal. pcbi. 1002489

6. Shilyansky, C, Karlsgodt, KH, Cummings, D, Sidiropoulou, K, Hardt, M, James, AS, Ehninger, D, Bearden, CE, Poirazi, P, Jentsch, D, Cannon, TD, Levine, MS, Silva, AJ. “Neurofibromin regulates corticostriatal inhibitory networks during working memory performance”, Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29) :13141-6. Epub 2010 Jul 12.

7. Zhou Y, Won J, Karlsson MG, Zhou M, Rogerson T, Balaji J, Neve R, Poirazi P, Silva AJ. “CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala. ” Nature Neuroscience, vol. 12, No 11, pg. 1438-43, Nov 2009.

8. Poirazi, P. Brannon, T. & Mel, B. W. “Arithmetic of Subthreshold Synaptic Summation in a Model CA1 Pyramidal Cell. ” Neuron, vol 37, pg. 977-987, March 2003.

9. Poirazi, P. Brannon, T. & Mel, B. W. “Pyramidal Neuron as 2-Layer Neural Network. ” Neuron, vol 37, pg. 989-999, March 2003.

10. Poirazi, P. and Mel, B. W. “Impact of Active Dendritic Processing and Structural Plasticity on Learning and Memory. ” Neuron, vol 29, pg. 779-796, March 2001. 

Panayiota Poirazi

Research Director
Computational Biology Laboratory
Institute of Molecular Biology and Biotechnology (IMBB)
Foundation of Research and Technology-Hellas (FORTH)
Vassilika Vouton, P. O. Box 1385, GR 70013, Heraklion, Crete
GREECE

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