Connecting European Neuroscience

Rui M. Costa

Chair, Programme Committee for the FENS Forum (2014 - 2016)

Curriculum Vitae

Professional and academic career

Education/Training

2002
PhD in Neuroscience, UCLA/University of Porto, Portugal
1996
DVM, Veterinary Medicine, Technical University of Lisbon, Portugal

Employment/Experience

2002-2005
Postdoctoral Fellow, Dr. M. Nicolelis, Duke University, USA
2006-2009
Chief, Section of In-Vivo Neural Function, NIAAA, NIH, USA
2009-present
Investigator, Champalimaud Neuroscience Program, Portugal

Honours and awards

2001-2002
Young Investigator Award, National Neurofibromatosis Foundation, NY, USA
2009-2014
ERC Starting Grant, European Research Council, Brussels, Belgium
2010
Seeds of Science Prize for Life Sciences 2010, Portugal
2012-2017
IECS, Howard Hughes Medical Institute, MD, USA
2012
Young Investigator Award, Society for Neuroscience, USA

Administrative and organisational experience

2006
Member of the “Intramural Roadmap Committee”, NIH
2007-present
Associate Editor, Frontiers in Integrative Neuroscience
2008-present
President, American-Portuguese Biomedical Research Fund, NY, USA
2011-present
Vice-President, Portuguese Society for Neuroscience
2011-2012
Deputy Director, Champalimaud Neuroscience Program
2012-present
Editor, Genes, Brain and Behaviour
2012-present
Scientific Council, Bial Foundation

Previous position as FENS officer
Member, Programme Committee for the FENS Forum (2012 - 2014)

Research interests

General goal:
Integrative approach to investigate the neurobiology of action
Research areas:
Molecular, cellular, and systems mechanisms of action generation; sequence and skill learning, goal-directed actions versus habits. Across-level approach to study cognitive and sensorimotor disorders in mouse models - PD, OCD, NF1, autism.
Major Tools:
Gene targeting in mice Neuronal ensemble electrophysiology in behaving mice, Slice electrophysiology in mice Optogenetics and molecular imaging in mice Mouse behavioural analysis.

Selected Publications

  • Cui, G*, Jun SB*, Jin, X, Pham, MD, Vogel SS, Lovinger DM & Costa RM. (2012) In-Vivo Optical Measurements Reveal Concurrent Activation of Striatal Direct- and Indirect-Pathway Neurons During Movement Initiation. Nature. doi: 10.1038/nature11846
  • Koralek, AC*, Jin, X*, Long II, JD, Costa RM*, Carmena JM*. (2012). Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills. Nature, 483(7389): 331-5. doi: 10.1038/nature10845
  • French CA, Jin X, Campbell TG, Gerfen E, Groszer M, Fisher SE, Costa RM (2011). An Aetiological Foxp2 Mutation Causes Aberrant Activity and Synchrony of Striatal Circuits. Molecular Psychiatry. doi: 10.1038/mp.2011.105
  • Costa, RM (2011). A selectionist account of de novo action learning. Curr Opin Neurobiol. 21(4): 579-86
  • Jin X & Costa RM (2010). Start/stop signals emerge in nigrostriatal circuits during sequence learning. Nature; 466(7305): 457-62
  • Dias-Ferreira, E., Sousa, J.C., Melo I., Morgado P., Mesquita, A.R., Cerqueira J.J., Costa, R.M.*, Sousa N. * (2009). Chronic stress causes frontostriatal reorganization and impairs decision-making. Science; 325(5940): 621-5.
  • Yin, H.H., Prasad-Mulcare, S., Hilario, M.R.F., Clouse, E., Davis, M. I., Lovinger, D.M., Costa, R.M. (2009). Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. Nature Neuroscience, 12:3
  • Cui, Y., Costa R. M., Murphy G. G., Elgersma, Y., Zhu, Y., Gutmann, D.H., Parada, L.F., Mody, I., Silva A. J. (2008). Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell, 31; 135(3): 549-60
  • Costa, R.M., Lin, S.C., Sotnikova, T.D., Cyr, M., Gainetdinov, R.R., Caron, M.G., Nicolelis M.A.L. (2006). Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction. Neuron, 52(2): 359-69
  • Costa, R.M.*, Cohen, D. *, Nicolelis M.A.L. (2004). Differential corticostriatal plasticity during fast and slow motor skill learning in mice. Current Biology, 14(13): 1124-34
  • Costa, R.M., Federov, N.B., Kogan, J.H., Murphy, G.G., Stern, J., Ohno, M., Kucherlapati, R., Jacks, T. and Silva, A.J. (2002). Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1. Nature, 415 (6871): 526-30
  • Costa, R.M.*, Yang, T. *, Huynh, D.P., Pulst S.M., Viskochil, D.H., Silva, A.J. and Brannan, C.I. (2001). Learning deficits, but normal development and tumour predisposition, in mice lacking exon 23a of the Neurofibromatosis type I gene. Nature Genetics, 27, 399-405

Rui Manuel Marques Fernandes da Costa D.V.M., Ph.D.

Champalimaud Neuroscience Program
Champalimaud Center for the Unknown
Av. De Brasília, Doca de Pedrouços
1400-038 Lisbon
Portugal

loading