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.: Bovolenta, Paola

Publication Committee Member

Paola Bovolenta
Full Professor and Chair Cell. Mol and Dev Neurobiology Dept.
Instituto Cajal, CSIC
Dr. Arce 37
28002 Madrid
Spain
Phone (office): +34 91 585 4717
Phone (lab): +34 91 585 4715
Fax: +34 91 585 4754
E-mail: bovolenta@cajal.csic.es

Curriculum Vitae

Personal

Date of birth: 11.11.1957

Education

1981
BS, University of Florence (Florence, Italy) - Pharmacology
1984
M.S., New York University, Sch. Med (New York, USA) - Dev. Neurobiol
1986
Ph.D., New York University, Sch. Med (New York, USA) - Dev. Neurobiol
1986
Postdoc, New York University, Sch. Med (New York, USA) - Dev. Neurobiol
1986-1988
Postdoc, Columbia University, Col. Phys. & Surg, (New York, USA) - Dev. Neurobiol

Previous employment

1989-1993
Research Associate, Instituto Cajal, Consejo Superior de Investigaciones Cientificas (CSIC).
1993-2002
Staff Scientist, Instituto Cajal, CSIC.
1995
Visiting Scientist, HSR-DIBIT, Milan, Italy
2000
Invited Professorship, École Normale Supérieure, Paris, France.
2002-2004
Associate Professor, Instituto Cajal, CSIC.
2005-present
Full Professor, Chair of Cell Mol and Developmental Neurobiology Department

Experience and honours

2008-present
European Editor Developmental Neurobiology
2005-present
Editorial Board Development
2005
Guest Editor, Journal of Neurobiology Special Issue "Unexpected roles for morphogens in the development and regeneration of the CNS" (15 September, 2005)
July 2008-present
Contributing Editor for the European Journal of Neuroscience
2002-present
Editorial Board The Tohoku J Exp. Medicine
2001-2008
Editorial Board Journal Neurobiology (now Developmental Neurobiology)

2008-present
Coordinator of the Biology and Biomedicine area of the CSIC
2005-present
Co-Manager of the Spanish Nat. Evaluation Agency (ANEP), Cell&Mol. Biol.
2006-present
Scientific Committee, Telethon Combatti la Distrofia Muscolare e La Altre Malattie Genetiche, Italy

2008
Scientific Committee-Site Visit: Institut du Fer à Moulin (Director Jean-Antoine Girault, INSERM. 19 March
2007-2010
Scientific Committee, "LS4-Neurosciences" European Research Council (ERC) Starting Grants.
March 2006
Scientific Committee-Site Visit: Telethon Institute of Genetics and Medicine (TIGEM). Naples
2004
Study Section FP6-2003-LifeSciHealth-1.
2004
Study Section "Programa Ramón y Cajal".
September 2003
Scientific Committee-Site Visit: "Kondoh Differentiation Signalling Project". Programme: Exploratory Research for Advanced Technology (ERATO) de la Japan Science and Technology Cooperation (JST), Kyoto
2002-2004
Study Section FP6-Mobility1 Marie Curie, RTN Program.
July 2002
Study Section Spanish Ministry Education & Science (Mol. Biology Area).

August 2008
Discussion Leader and Speaker selection. Gordon Research Conference: "Visual System Development", New Port, RI., USA
September 2006
Session co-chair and abstract selection. "Axon guidance and neuronal plasticity". Cold Spring Harbor Laboratory Mtg. Cold Spring Harbor, NY., USA
2000-2003
Organizing committee, ESF Workshops, Investigation of the genetic aetiology of the developmental eye defects-microphthalmia, anophthalmia and coloboma (MAC).
2001
Co-organizer, Juan March Foundation Workshop, Signalling at the Growth Cone.

Selected Publications

  • Trousse F., Esteve P. and Bovolenta P. (2001) BMP4 mediates apoptotic cell death and proliferation in the chick optic cup. J. Neurosci. 21, 1292-1301.
  • Martinez-Morales JR, Signore M, Acampora D, Simeone A. and Bovolenta P. (2001). Otx genes are required for tissue specification in the developing eye. Development 128, 2019-2030.
  • Rodríguez de Córdoba, S. Gallardo, M.E., Lopez-Rios, J., and Bovolenta P. (2001). The human Six family of homeobox genes. Cur. Genomics, 231-242. (Cover caption article)
  • Trousse F., Marti E., Gruss P., Torres M. and Bovolenta P. (2001) Control of retinal ganglion cell axon growth: a new role for Shh. Development 128, 3927-3936. (Cover caption article) Comment in: Nat. Neurosc. Rev. 2001, 2, 853
  • Barbieri A.M., Broccoli V., Bovolenta P., Alfano G., Marchitiello A., Mocchetti C., Crippa L., Bulfone A., Marigo V., Ballabio A. and Banfi S. (2002). Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma. Development 129, 805-813.
  • Martí E. and Bovolenta P. (2002). Sonic hedgehog in CNS development: one signal, multiple outputs. Trends Neurosci. 25, 89-96.
  • del Arco A., Morcillo J, Martinez-Morales J.R., Galian C., Martos V., Bovolenta P and J. Satrustegui (2002) Expression of the aspartate-glutamate mitochondrial carriers Aralar1 and citrin during development and in adult rat tissues. Eur. J. Biochem. 269, 1-8.
  • Lopez-Rios J., Tessmar K, Wittbrodt J. and Bovolenta P. (2003) Six3 and Six6 activity is modulated by members of the groucho family. Development 130, 185-195
  • Esteve P., Trousse F., Rodriguez J. and Bovolenta P. (2003). SFRP1 modulates retina cell differentiation through a ?catenin-independent mechanism. J. Cell Sci. 116, 2471-2481. (Highlights in "In this issue J. Cell Sci" and in Development).
  • Martínez-Morales J.R., Dolez V., Rodrigo I., Zaccharin; R., Leconte L., Bovolenta P*. and Saule S*. (2003) OTX2 activates the molecular network underlying retina pigment epithelium differentiation. J. Biol. Chem. 278, 21721-21731. *co-senior authors
  • Ramos, M, delArco, A, Pardo, B, Martínez-Serrano, A, Martinez-Morales, J.R., Kobayashi, K, Bogónez, E., Bovolenta P., Saheki, T., and Satrústegui, J. (2003) Developmental changes in the Ca2+-regulated mitochondrial aspartate-glutamate exchanger aralar1 in brain and prominent expression in the spinal cord. Dev. Brain Res. 143, 33-46.
  • Rodrigo I., Bovolenta P., Mankoo,B. S. and Imai K. (2004) Meox genes regulate Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter. Mol. Cell Biol. 24, 2757-2766.
  • Esteve P., López-Ríos J. and Bovolenta P. (2004). Sfrp1 is required for the proper establishment of the eye field in the medaka fish. Mech. Dev. 121, 687-701
  • Martínez-Morales J.R., Rodrigo I., and Bovolenta P. (2004) Eye development: a view from the pigmented epithelium. BioEssays 26, 766-777.
  • García-Hoyos M., Cantalapiedra D., Arroyo C., Esteve P., Rodríguez J, Riveiro R., Trujillo M.J., Ramos C., Bovolenta P., Ayuso C. (2004). Evaluation of SFRP1 as a candidate for human retinal dystrophies. Mol. Vis. 10, 426-431
  • Gallardo, M.E., Schneider, A.S., Dwyer M.A., Ayuso, C., Bovolenta, P. and Rodríguez de Córdoba, S. (2004) Analysis of the developmental SIX6 homeobox gene in patients with anophthalmia/microphthalmia. Am. J. Med. Genet. 129A, 92-94.
  • Plouhinec, JL, Leconte, L, Sauka-Spengler, T, Bovolenta, P., Mazan, S and Saule, S (2005) Comparative analysis of gnathostome Otx genes expression patterns in the developing eye: implications for the functional evolution of the multigene family. Dev. Biol. 278: 560-575.
  • Martinez-Morales, J.R, Del Bene, F., Nica G., Hammerschmidt M., Bovolenta P.* and Wittbrodt, J.* (2005) Differentiation of the vertebrate retina is coordinated by an FGF signaling center. Dev Cell 8, 565-574. *co-senior authors.
  • Bovolenta P. (2005) Morphogen signalling at the vertebrate growth cone: a few cases or a general strategy? J. Neurobiol. 64, 405-416 (cover caption article).
  • Bovolenta, P. and Marti E. (2005) Un-expected roles for morphogens in development and regeneration of the CNS. Introduction to the Special Issue. J. Neurobiol. 64, 321 323.
  • Sanchez-Camacho C., Rodríguez J., Ruiz JM., Trousse F. and Bovolenta P. (2005) Morphogens as growth cone signalling molecules. Brain Res. Review 49, 242-252.
  • Conte, I., Morcillo, J. and Bovolenta P. (2005) Comparative analysis of the distribution of Six3 and Six6 in the developing and adult mouse brain Dev. Dyn. 234, 718-25.
  • Rodríguez, J., Esteve, P., Weinl, C., Ruiz, J.M., Fermin Y., Trousse, F., Dwivedy A, Holt C.E. and Bovolenta P. (2005) SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor. Nat Neurosci. 8, 1301-1309. (News and Views 8, 1281-1282)
  • Martí E, García-Campmany, L. and Bovolenta P. (2006) Dorso-ventral patterning of the vertebrate nervous system. En: "Cell signalling and growth factors in development" K. Unsicke and K. Krieglstein (Eds). Wiley-VCH. Growth Fact 2Vol, ISBN 3-527-31034-7 pp. 361-394
  • Esteve P and Bovolenta P. (2006) Secreted inducers in vertebrate eye development: more functions for old morphogens. Curr. Opin. Neurobiol. 16, 1-7.
  • Morcillo J., Martinez-Morales, J.R, Trousse, F., Fermin Y., Sowden J. and Bovolenta P. (2006). Proper patterning of the optic fissure requires the sequential activity of Bmp7 and Shh. Development 133, 3179-3190. (Highlighs in "Development" and in Nat. Rev. Neurosc. 2006, 7, 684)
  • Bovolenta P. Rodríguez, J., Esteve, P. (2006) Frizzled/Ryk mediated signalling in axon guidance. Development 133, 4399-4408.
  • Conte I. and Bovolenta P. (2007) Comprehensive characterization of the cis-regulatory code responsible for the spatio-temporal expression of olSix3.2 in the developing medaka forebrain. Genome Biol. 8: R137, 1-17.
  • Merchán, P.*, Bribián A*, Sánchez-Camacho C.*, Lezameta, M., Bovolenta P. and de Castro F. (2007) Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors. Mol. Cell. Neurosci. 36, 355-368. * co-authors.
  • Bovolenta P., Esteve P., Ruiz J.M., Cisneros E. and Lopez-Rios, J. (2008) Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease. J. Cell Sci. 121: 737-746.
  • Lopez-Rios, J* Esteve, P*, Ruiz JM and Bovolenta P. (2008) The netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonises their activity in the anterior neural plate. Neural Development, 3: 19.
  • Sánchez-Camacho C. and Bovolenta P. (2008) Autonomous and non autonomous Shh signalling mediate the in vivo growth and guidance of mouse retina ganglion cell axons. Development, 135, 3531-3540 (cover caption article)
  • Bovolenta P. Marco-Ferreres, R and Conte I. (2009) Retinal development: Embryology and early patterning. In: Encyclopedia of the Eye, First Edition. Chapter 249. Elsevier (in press).
  • Bovolenta. P. and Cisneros, E. (2009). Retinitis Pigmentosa: cone photoreceptors starving to death. Nat. Neurosci. 12, 5-7 (N&V)