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.: Epelbaum, Jacques

Chair Communication and Publication Committee

Jacques Epelbaum.
Centre de Psychiatrie & Neuroscience
UMR 894 Inserm

Faculté de Médecine
Université Paris Descartes
2 ter rue d'Alésia
75014 Paris
France
E-mail: jacques.epelbaum@inserm.fr

Curriculum Vitae

Cursus

2009-
Directeur de Recherche (classe exceptionnelle)
2001-2008
Directeur de Recherche Inserm (1ere classe)
1987-2000
Directeur de Recherche Inserm (2eme classe)
1982-1986
Chargé de recherche Inserm (= Chargé 1ere classe)
1979-1981
Attaché de recherche Inserm (= Chargé 2eme classe)
1978-1979
Bursar FRM, Inserm U 159 (Dr. C Kordon)
1975-1977
Killam fellow, McGill Univ. & Montreal Neurological Institute (Prof. JB Martin)
1973-1974
PhD student U 109 Inserm (Prof JC Schwartz/ Dr. C Kordon)

Current activities

1/2008-present
Directeur, Centre de Psychiatrie & Neuroscience Sainte Anne, UMR 894 Inserm
9/2006-present
Recipient of a contrat d'interface Inserm/Université Paris Descartes
1/2006-present
Université Paris Descartes Strategic advisory board member

Other activities et Professional Memberships (selected)


Editorships/Editorial Boards:
Redacteur en chef: La lettre des Neurosciences (1991-95)
Deputy Chief Editor : J. Neuroendocrinology (1996-2002)
Editorial Board member : Endocrinology (2000-03); Neuroendocrinology (1984-87); Médecine/Sciences. (2002-); Psychoneuroendocrinology (2008-2010)

Study sections and scientific advisory boards:
Advisory Panel, NIH/NIA Aging Systems and Geriatrics Study Section (2007-10)
Membre du Conseil Scientifique de l'Inserm (2003-08)
Président de la commission de physiologie animale de l'INRA (2003-07)
Chairman French Israeli committee for neuroscience (1997-99)
Président de la commission de neurosciences intégratives Inserm (1995-98)
Canadian MRC Endocrinology Committee member (1990-93)
Membre de la commission d'Endocrinologie de l'Inserm (1986-1990)

Foundations
Conseil scientifique France Alzheimer (2007-2010)
Conseil scientifique Fondation Santé et Radiofréquences (2007-2009)

Professional Societies
Président, Société de Neuroendocrinologie (2008-10)
Executive committee Member, International Federation for Neuroendocrinology (2008-10)
Secrétaire général de la Société des Neurosciences, (1999-2001)

Teaching
2005-present
Co-responsable de la spécialité Biologie du Vieillissement du Master Recherche Paris Descartes co-habilité Paris Diderot
2005-present
Responsable d'une unité de valeurs de neuroendocrinologie Master recherche Paris Sud, co-habilité UPMC Paris Descartes et Paris Diderot
2005-present
Membre du directoire de l'école doctorale GC2ID, Paris Descartes et Paris Diderot

Tutoring
9 Post-Docs (N. Briard-Debus, Z. Csaba, D. Djordjevic, DD Feng, G. Prévost, A Stéphan, A. Vasilaki, S. Yang, J. Zhang)
19 PhDs (C. Benzaki-Apert, J. Bertherat, K Bouyer, AS Carlo, P. Dournaud, E. Duron, V. Heidet, L. Kappeler, S. Krantic, I. Lagny-Pourmir, C. Lanneau, G Lepousez, E. Moyse, F. Musset, E. Pellegrini, L. Tapia-Arancibia, V. Tolle, Cécile Viollet, R. Winsky-Sommerer)
8 Masters (C. Benzaki-Apert, J. Bertherat, D. Iancu-Gontard, L. Kappeler, E. Moyse, J. Perrot, L. Tapia-Arancibia, R. Winsky-Sommerer)

Grants since 2004

PHRC ENDANO 90 K€ (2008-11, partner J. Epelbaum)
Centre Inserm de Psychiatrie & Neuroscience 980 k€/an (2008-10, PI: J Epelbaum)
Biomeasure 80 k€ (2008-9, PI: J Epelbaum)
ANR Restrikal 45 k€ (2007-10, partner J. Epelbaum)
PHRC SIGAL, 50 k€ (2007-9, partner J. Epelbaum)
ATC vieillissement 15 k€ (2004-06, partner: J. Epelbaum)

Summary of research

Since the beginning of my research, I have been working on neuropeptides and their function in brain, particularly on somatostatin. From 1991 on, we demonstrated the presence of somatostatin receptors on GHRH neurons in the hypothalamus and studied their functions in the intrahypothalamic network involved in the control of GH secretion.
We also demonstrated the presence of somatostatin receptors on different human tumor types that led to the use of somatostatin agonists in the management of pituitary and neurroendocrine tumors. We also characterized the somatostatin deficits linked to age-associated diseases such as Alzheimer disease dementia.
Since 2000, we are also investigating the role of preproghrelin derived peptide in the neuroendocrine control of GH secretion, feeding behaviour and energy balance. 184 articles in medline, 88 reviews or book chapters and more than 400 abstracts. I authored 5 books et gave 155 invited seminars or conferences (24 since 2004)

Meeting organisation

19 french colloquia since 1987 and 16 abroad since 1990

Selected Publications

  • 1. Bertherat J, Dournaud P, Berod A, et al. Growth Hormone-Releasing Hormone-synthesizing neurons are a subpopulation of somatostatin receptor-labeled cells in the rat arcuate nucleus - a combined insitu hybridization and receptor light-microscopic autoradiographic study Neuroendocrinology 56 (1): 25-31 1992
  • 2. Bertherat J, Brue T, Enjalbert A, et al. Somatostatin receptors on thyrotropin-secreting pituitary-adenomas - comparison with the inhibitory effects of octreotide upon invivo and invitro hormonal secretions JCEM 75 (2): 540-6 1992
  • 3. Bertherat J, Timsit J, BluetPajot MT, et al.Chronic Growth-Hormone (GH) hypersecretion induces reciprocal and reversible changes in mRNA levels from hypothalamic GH-releasing hormone and somatostatin neurons in the rat J Clin Invest 91 (4): 1783-91 1993
  • 4. Dournaud P, Cervera-Pierot P, Hirsch E, et al. Somatostatin messenger rna-containing neurons in alzheimers-disease - an in-situ hybridization study in hippocampus, parahippocampal cortex and frontal-cortex Neuroscience 61 (4): 755-64 1994
  • 5. Epelbaum J, Dournaud P, Fodor M, Viollet C. The Neurobiology of Somatostatin. Crit Rev Neurobiol 8: 25-44 1994
  • 6. Ichai C, Chevallier N, Delaere P, et al. Influence of region-specific alterations of neuropeptidase content on the catabolic fates of neuropeptides in alzheimers-disease J Neurochem 62 (2): 645-55 1994
  • 7. Tolle V, Bassant MH, Zizzari P, et al. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats Endocrinology 143 (4): 1353-61 2002
  • 8. Tolle V, Kadem M, Bluet-Pajot MT, et al. Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women JCEM 88 (1): 109-16 2003
  • 9. Pantel J, Legendre M, Cabrol S, et al. Loss of constitutive activity of the Growth Hormone Secretagogue Receptor in familial short stature. J Clin Invest 116 (3): 760-8 2006
  • 10. Dardennes RM, Zizzari P, Tolle V, et al. Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: Association with subtype, body-mass index, severity and age of onset. Psychoneuroendocrinology. 32(2):106-113. 2007