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.: Moroni, Flavio

Communication and Publication Committee Member

Flavio Moroni M.D.
Dipartimento di Farmacologia Preclinica e Clinica -
Università degli Studi di Firenze
Viale Pieraccini 5
50135 Firenze
Italy
Phone: 055/ 4271 266
Fax: 055/ 4271 335
E-mail: flavio.moroni@unifi.it

Curriculum Vitae

Education

1969
Medical Doctor (Summa cum Laude)
1970
Specialist in Medical Toxicology
1971
Specialist in Anaestesiology

Professional experience

1969-1971
Post doctoral fellow, Institute of Pharmacology and Toxicology University of Florence, Italy.
1971-Summer
Visiting Physician Regional Poisoning Treatment Center, The Royal Infirmary, Edinburgh G.B.
1971-1976
Assistant Professor of Pharmacology Institute of Pharmacology and Toxicology University of Florence.
1976-1978
Visiting Associate, Laboratory of Preclinical Pharmacology, N.I.M.H., Washington D.C. U.S.A.
1982-1986
Associate Professor of Pharmacology, Medical Faculty, University of Florence.
1983-1985
Professor of Pharmacology, School of Dentistry, University of Ferrara.
1986-1988
Full Professor of Psychopharmacology, School of Medicine, University of Florence.
since 1988
Full Professor of Pharmacology, School of Medicine, University of Florence.
1993-2000
Full Professor of Molecular and Cellular Pharmacology, Science Faculty, University of Florence.
since 2002
Director of the Medical Toxicology Clinical Unit, Careggi University Hospital, Florence.

Societies

Società Italiana di Farmacologia
American Society for Neurosciences
Italian Society for Neurosciences
European Society for Neurosciences
International Brain Research Organization
European College of Neuropsycopharmacology
Italian Study group on Brain Aging
Societa' Italiana di Tossicologia
European College of Neuropsychopharmacology

Editorial Posts (past and present)

J. Neurochemistry
European J. Pharmacology
Neurochemical Research
Il Farmaco
NeuroReport
Molecular Neuropharmacology

Honors and Other Recognitions

Scientific Awards of the University of Florence for the years 1975, 1978, 1981
Scientific Award "Alberico Benedicenti" of the Italian Pharmacological Society for the year 1978.
Member of the Scientific Advisory Board of "Istituto di Psicobiologia e Psicofarmacologia" C.N.R. Rome (1979-1983)
Member of the Board of Italian Study Group of Brain Aging (1988-1991)-(1993-2002)
Chairman of the organizing Committee of the Congress on "Excitatory amino acid" Padova, May 21-26; 1990 (see the proceeding: Meldrum B.S., Moroni F., Simon R.P., Woods J.H eds. "EXCITATORY AMINO ACIDS" Raven Press, New York, 1991. Secretary General of the IBRO 2011 Florence Meeting
Member of the organizing committees of the Congress on Metabotropic Glutamate Receptors, Taormina, Sicily (see the proceedings: Moroni F., Nicoletti F., Pellegrini-Giampietro D. eds. "METABOTROPIC GLUTAMATE RECEPTORS AND BRAIN FUNCTION" Portland Press, London, 1996)
Member of the organizing Committee of the National Congress of the "Italian Pharmacological Society, Florence June 20-23rd 1999
Elected Member of "Consiglio di Amministrazione" University of Florence (1989-1993)
Project leader for european grants on metabotropic glutamate receptors (Commission of the European Union- Biomed 1; Biomed 2 and Biotech programs). Project leader for national COFIN and FIRB projects on neurodegenerative disorders and stroke Project leader for Clinical Research on Drug Addiction supported by AIFA
Elected Member of the Italian Neuroscience Ruling Committee. President elect of the International Society for Tryptophan Research Secretary General of IBRO 8° Word Congress, 2011 President of the Ethical Committee for Drug Evaluation in Humans (Meyer Pediatric Hospital-University of Florence)
Frequently invited to organize Congress, Conference, Symposia, and to give lectures in International Congress, in recognized European and American Universities and other Research Institutions.

Selected Publications

  • Faraco G, Pittelli M, Cavone L, Fossati S, Porcu M, Mascagni P, Fossati G, Moroni F, Chiarugi A.(2009) Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo. Neurobiol Dis. 2009 IF 4,85
  • Landucci E, Boscia F, Gerace E, Scartabelli T, Cozzi A, Moroni F, Mannaioni G, Pellegrini-Giampietro DE. (2009) Involvement of endocannabinoid signaling in the neuroprotective effects of subtype 1 metabotropic glutamate receptor antagonists in models of cerebral ischemia. Int Rev Neurobiol;85:337-50.IF3,67
  • Formentini L, Moroni F, Chiarugi A (2009) Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo. Biochem Pharmacol.77:1612-20. IF:4,83
  • Moroni F, Formentini L, Gerace E, Camaioni E, Pellegrini-Giampietro DE, Chiarugi A, Pellicciari R. (2009) Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. ;157:854-62.IF:4,9
  • Formentini L, Macchiarulo A, Cipriani G, Camaioni E, Rapizzi E, Pellicciari R, Moroni F, Chiarugi A. (2009) Poly(ADP-ribose) catabolism triggers AMP-dependent mitochondrial energy failure. J Biol Chem. 284:17668-76. IF 5,9
  • Moroni F, Chiarugi A. (2009) Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment. FEBS J. 276:36-45.IF: 3,26
  • Formentini L, Arapistas P, Pittelli M, Jacomelli M, Pitozzi V, Menichetti S, Romani A, Giovannelli L, Moroni F, Chiarugi A.(2008) Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP-1-dependent cell death. Br J Pharmacol.155:1235-49.IF 4,92
  • Scartabelli T, Gerace E, Landucci E, Moroni F, Pellegrini-Giampietro DE. (2008) Neuroprotection by group I mGlu receptors in a rat hippocampal slice model of cerebral ischemia is associated with the PI3K-Akt signaling pathway: a novel postconditioning strategy? Neuropharmacology.55:509-16; IF 3,38
  • Boscia F, Ferraguti F, Moroni F, Annunziato L, Pellegrini-Giampietro DE.(2008) mGlu1alpha receptors are co-expressed with CB1 receptors in a subset of interneurons in the CA1 region of organotypic hippocampal slice cultures and adult rat brain. Neuropharmacology. 55:428-39; IF 3,38
  • Moroni F. (2008) Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage.Curr Opin Pharmacol. 8: 96-103; IF 4,59
  • Pellicciari R, Camaioni E, Costantino G, Formentini L, Sabbatini P, Venturoni F, Eren G, Bellocchi D, Chiarugi A, Moroni F. (2008) On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 6 : 914-23. IF: 2,3
  • Aldinucci, A., Gerlini, G., Fossati, S., Cipriani, G., Ballerini, C., Biagioli, T., Pimpinelli, N., Borgognoni, L., Massacesi, L., Moroni, F. + Chiarugi, A. (2007)  A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation. J. Immunol. 179: 305-312. IF: 7,42
  • Faraco, G., Fossati, S., Bianchi, M. E., Patrone, M., Pedrazzi, M., Sparatore, B., Moroni, F. + Chiarugi, A. (2007)  High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo. J. Neurochem. 103 :590-603. IF: 4,95
  • Fossati, S., Cipriani, G., Moroni, F. + Chiarugi, A. (2007)  Neither energy collapse nor transcription underlie in vitro neurotoxicity of poly(ADP-ribose) polymerase hyper-activation. Neurochem. Int. 50: 203-210. IF: 3,16
  • Giannini, L., Vannacci, A., Missanelli, A., Mastroianni, R., Mannaioni, P. F., Moroni, F. + Masini, E. (2007)  Amatoxin poisoning: a 15-year retrospective analysis and follow-up evaluation of 105 patients. Clin Toxicol. (Phila) 45: 539-542. IF: 1,1