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Gundelfinger, Eckart D.
Past Programme Chair of FENS 2006-2008
Prof. Dr. Eckart D. Gundelfinger
Leibniz Insitute for Neurobiology
Center for Learning & Memory Research
Dept. of Neurochemistry and Molecular Biology
Brenneckestr. 6
D-39118 Magdeburg, Germany
Research interests
Structure and function of chemical synapses: analysis of the proteome
of CNS synapses - molecular organization, plasticity and developmental
assembly of the presynaptic active zone and the postsynaptic density -
organization and function of the extracellular matrix at CNS synapses.
Current positions
Head of department, member of the board of directors and acting
scientific vice director of the Leibniz Institute for Neurobiology.
Combined with an appointment as a full professor at the Medical Faculty
of the Otto von Guericke University Magdeburg.
| Curriculum VitaePersonal- Born in 1953, married, 2 children
Education- 1979
- Diploma in Biology from Stuttgart University
- 1982
- PhD (Dr. rer. nat.) University of Stuttgart
- 1989
- Habilitation degree in Molecular Neuroscience
and Neuropharmacology; University of Heidelberg
Positions- 1980-1982
- Max Planck Institute for Biology; Dept. of Wolfgang Beermann
- 1982-1984
- Postdoc at the European Molecular Biology Laboratory (EMBL), Heidelberg.
- 1984-1988
- Staff scientist at Center for Molecular Biology, University of Heidelberg
(ZMBH), laboratory of Heinrich Betz
- 1988-1993
- Research group leader at the Center for Molecular Neurbiology,
University of Hamburg (ZMNH)
- since 1992
- Head of department at the Leibniz Institute for Neurobiology (IfN) Magdeburg
Awards & Honors- 1980-1982
- Max-Planck doctoral fellowship
- 1982-1984
- EMBO long-term fellowship
- 1988-1993
- BMBF research group sponsored by the Federal Government of Germany
- 2003
- Max Planck Prize for international collaborations by the Alexander von
Humboldt Foundation and the Max Planck Society
- 2006
- Neuroplasticity Prize of the Fondation IPSEN (5th FENS Forum, Vienna)
Activities- 2002-2004
- Member of the Review Committee for Program and Young Investigators
Grants of the Human Frontiers of Science Program Organization (HFSPO)
- since 2004
- Member of the Neuroscience Review Board (Fachkollegium
Neurowissenschaften) of the German Research Council (DFG)
- since 2005
- Co-speaker of the DFG Graduate Program "Cell-cell communication in the
nervous and immune system"
| Selected Publications- Altrock WD, tom Dieck S, Sokolov M, Meyer AC, Sigler A, Brakebusch C,
Faessler R, Richter K, Boeckers TM, Potschka H, Brandt C, Loescher W,
Grimberg D, Dresbach T, Hempelmann A, Hassan H, Balschun D, Frey JU,
Brandstätter JH, Garner CC, Rosenmund C, Gundelfinger ED (2003) Functional
Inactivation of a Fraction of Excitatory Synapses in Mice Deficient for
the Active Zone Protein Bassoon. Neuron 37: 787-800
- Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D,
Gundelfinger ED, Bowie JU (2006) An architectural framework that may
lie at the core of the post-synaptic density. Science 311, 532-535
- Bresler T, Shapira M, Boeckers T, Dresbach T, Futter M, Garner CC, Rosenblum K,
Gundelfinger ED, Ziv N. (2004). Post Synaptic Density Assembly is
Fundamentally Different from Presynaptic Active Zone Assembly. J Neurosci 24: 1507-1520
- Dick O, tom Dieck S, Altrock WD, Ammermüller J, Weiler R, Garner CC,
Gundelfinger ED, Brandstätter JH (2003). The Presynaptic Active Zone Protein
Bassoon is Essential for Photoreceptor Ribbon Synapse Formation in the
Retina. Neuron 37: 775-786
- Dresbach T, Torres V, Wittenmayer N, Altrock WA, Zamorano P, Zuschratter W,
Nawrotzki R, Ziv NE, Garner CC, Gundelfinger ED (2006) Assembly of Active Zone
Precursor Vesicles: Obligatory Trafficking of Presynaptic Cytomatrix Proteins
Bassoon and Piccolo via a trans-Golgi Compartment. J Biol Chem 281:6038-47
- Gundelfinger ED, Kessels MM, Qualmann B. (2003). Temporal and spatial coordination
of exocytosis and endocytosis. Nat Rev Mol Cell Biol 4:127-139
- Gundelfinger ED, Boeckers TM, Baron M, Bowie JU (2006) A role for zinc in
post-synaptic density asSAMbly and plasticity? Trends Biochem Sci, 31:366-373.
- Khimich D, Nouvian R, Pujol R, tom Dieck S, Egner A, Gundelfinger ED, Moser T.
(2005) Hair Cell Synaptic Ribbons are Essential for Synchronous Auditory Signaling.
Nature 434: 889-894
- tom Dieck S, Altrock WD, Kessels MM, Qualmann B, Regus H, Brauner D, Fejtová A,
Bracko O, Gundelfinger ED, Brandstätter JH (2005) Molecular Dissection of
the Photoreceptor Ribbon Synapse: Physical Interaction of Bassoon and RIBEYE
is Essential for the Assembly of the Ribbon Complex. J. Cell Biol 128: 825-836
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