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Past Committee Members
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.: Manahan-Vaughan, Denise

Past Chair NENS Committee

Dr. Denise Manahan-Vaughan
Ruhr-Universität Bochum
International Graduate School for Neuroscience
44780 Bochum
Germany
Phone: 0234 322 6955
Fax: 0234 321 4490
E-mail: dmv-igsn@rub.de

Research

Investigations of the roles of hippocampal long-term potentiation (LTP) and long-term depression (LTD) in the formation of declarative memory.

Curriculum Vitae

Education

1988
BSc (mod) Nat Sci (hons) majoring in Physiology. Trinity College Dublin, Ireland
1992
PhD in Neuropharmacology, Trinity College Dublin, Ireland
1998
Habilitation degree (docent) in Physiology, Medical Faculty, Otto von Guericke University Magdeburg, Germany

Professional experience

1992-1994
Postdoc, Lecturer in Physiology, Trinity College Dublin, Ireland.
1994-1996
Postdoctoral fellow, Leibniz Institute of Neurobiology, Magdeburg, Germany
1996-1999
Research Assistant, Leibniz Institute of Neurobiology, Magdeburg, Germany
1999-2003
Head of Synaptic Plasticity Research Lab, Johannes Mueller Institute of Physiology, Charité (Medical Faculty of the Humboldt University), Berlin Germany.
since 2003
Professor of Neuroscience

Dean of Studies and Director of the Internarional Graduate School of Neuroscience, Ruhr University Bochum, Germany.

Head of Learning and Memory Research, Medical Faculty, Ruhr University Bochum, Germany.

Activities

Neuroscience representative for the Ruhr University Bochum
Speaker (Chair) of the Kompetenznetzwerk NRW (Competence Network of the State of Northrhine Westphalia)
Coordinator of the Marie Curie, Early Stage Training, Host site NovoBrain
Committee Member of the FENS/IBRO Programme of European Neuroscience Schools
Committee Member of the IBRO Neuroscience Training Network (NPN)

Selected Publications

  • Kemp A, Manahan-Vaughan D. (2007) Hippocampal long-term depression: master or minion in declarative memory processes? Trends Neurosci. 30:111-118.
  • Tsanov M, Manahan-Vaughan D. (2007) The adult visual cortex expresses dynamic synaptic plasticity that is driven by the light/dark cycle. J Neurosci.27:8414-8421.
  • Tsanov M, Manahan-Vaughan D. (2007) Intrinsic, light-independent and visual activity-dependent mechanisms cooperate in the shaping of the field response in rat visual cortex. J Neurosci. 27:8422-8429.
  • Lemon N, Manahan-Vaughan D (2006) Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal LTP and LTD. J. Neurosci, 26: 7723-7729.
  • Manahan-Vaughan D, Braunewell KH. (2005) The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity. Cereb Cortex. 15:1703-1713.
  • Kemp A, Manahan-Vaughan D. (2005) The 5-hydroxytryptamine4 receptor exhibits frequency-dependent properties in synaptic plasticity and behavioural metaplasticity in the hippocampal CA1 region in vivo. Cereb Cortex. 15:1037-1043.
  • Kemp A, Manahan-Vaughan D. (2004) Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition. Proc Natl Acad Sci U S A. 101:8192-8197.
  • Naie K, Manahan-Vaughan D. (2004) Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation. Cereb Cortex. 14(2):189-198.
  • Manahan-Vaughan D, Kulla A. (2003) Regulation of depotentiation and long-term potentiation in the dentate gyrus of freely moving rats by dopamine D2-like receptors. Cereb Cortex. 13(2):123-35.
  • Kulla A, Manahan-Vaughan D. (2002) Modulation by serotonin 5-HT(4) receptors of long-term potentiation and depotentiation in the dentate gyrus of freely moving rats. Cereb Cortex. 12(2):150-62.
  • Manahan-Vaughan D, Kulla A, Frey JU. (2000) Requirement of translation but not transcription for the maintenance of long-term depression in the CA1 region of freely moving rats. J Neurosci. 20(22):8572-6.
  • Kulla A, Manahan-Vaughan D. (2000) Depotentiation in the dentate gyrus of freely moving rats is modulated by D1/D5 dopamine receptors. Cereb Cortex. 10(6):614-20