Connecting European Neuroscience

EJN Best Publication Award 2015

EJN Best Publication Award 2015

In collaboration with FENS and Wiley-Blackwell, EJN is proud to announce that the winner of the "Best Publication Award 2015" is Dr. Silvina Laura Diaz, PhD, DVM, Researcher at CONICET, Buenos Aires, Argentina and former post-doc at the Fer a Moulin Institute (INSERM/UPMC) in Paris, France, where experiments were conducted.

She receives this Award for her publication in EJN:

"Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin" (published in EJN volume 38, issue 5). The paper was coauthored by Nicolas Narboux-Nême (equal contribution to SLD), Sara Trowbridge, Sophie Scotto-Lomassese, Felix Kleine Borgemann, Sebastian Jessberger, Bruno Giros, Luc Maroteaux, Evan Deneris and Patricia Gaspar.

The study of Diaz, Narboux-Neme et al. challenged the idea of decreased neurogenesis in a hyposerotonergic brain. They demonstrated a counterintuitive increase of hippocampal cell survival in three different mice models with profound reductions of serotonin neurotransmission. Since this publication, these observations have been replicated in another model of hyposerotonergic mice (Sachs et al, Transl Psy 2013), supporting the concept that physiological levels of serotonin are essential for normal survival of adult-born neurons.

The work of Diaz & Narboux-Nême further explored the role of the serotonin system on physiological neurogenesis, and found that stimulation of the 5-HT1A receptors is sufficient to normalize the altered survival phenotype reported in serotonin-depleted mice. The 5-HT1A receptors are expressed by neural progenitors and GABAergic interneurons in the hippocampus (Klemplin et al., 2010). Particularly, parvalbumin-expressing GABAergic interneurons participate in the differentiation and maturation of progenitor cells in the dentate gyrus through BDNF, appearing as attractive targets to unravel the exact role of serotonin pathways on the fate of adult-born hippocampal neurons.

All in all, this article represents a relevant contribution and opened a series of exciting questions that are currently being addressed at Dr. Diaz’s laboratory in Argentina, to explore and better understand the pathways and mechanisms underlying hippocampal adult neurogenesis.

Dr. Diaz will receive this award of £3,000 at the upcoming FENS Regional Featured Meeting in Thessaloniki, 7 - 10 October 2015.

Silvina Laura Diaz

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