Connecting European Neuroscience

Ph.D. Student in Edinburgh/UK

07 December 2017

Ph.D. Student in Edinburgh/UK

Job ID


Developing and evaluating genetic therapies in Fragile X syndrome (2 studentships)

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and results from genetic silencing in the fragile X mental retardation 1 (FMR1) gene. The root cause of FXS is therefore insufficiency of the FMRP protein within the nervous system. Using cellular and rodent lines that model the disorder, the projects aim to develop and evaluate novel gene therapies for FXS. The projects will employ various molecular, cell biology and in vivo techniques to design and test potential gene therapies and DNA editing approaches for pre-clinical efficacy and safety.

The results generated in this project will help us to understand the tractability of FXS to genetic intervention at different neurodevelopmental stages and provide a springboard for the generation of novel therapeutic options in FXS disorder.

Prerequisites Candidates should have a BSc degree in a Biomedical Sciences, preferably with a background in Neuroscience or Molecular / Cell Biology.

The student should have experience of working in a laboratory and be able to perform general techniques such as making solutions and using pipettes.

The project is funded through the Patrick Wild Centre for Research into Autism, Fragile X Syndrome and Intellectual Disabilities.

The PhD will be supervised by Dr Stuart Cobb and Professor Peter Kind.

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Job Information

Closing date:
Contract length:
3.5 years
University of Edinburgh
Edinburgh Neurosciencce

Contact Information

Jane Haley
1 George Square
University of Edinburgh

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