Connecting European Neuroscience

Ph.D. Student in Trondheim/Norway

07 March 2018

Ph.D. Student in Trondheim/Norway

Job ID


A temporary, 3-year, full-time (100%) Position as PhD Research Fellow in Neuroscience is open for an outstanding candidate to investigate morphology-activity relationships underlying motor neuron vulnerability in amyotrophic lateral sclerosis (ALS). The candidate is expected to start in July 2018.

Project description
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder leading to severe dysfunction of motor neurons (MNs) and, inevitably, to death approximately 3-5 years after onset in most cases. It is the most common disorder amongst the group of motor neuron diseases, yet its specific aetiology is poorly understood. The disease characteristically involves a recognised pattern of selective neuropathy primarily affecting upper and lower MNs, i.e. MNs in the motor cortex, brainstem and spinal cord, and resulting in gradual paralysis and, ultimately, fatal respiratory failure.

A highly promising perspective towards a better understanding of ALS is the application of advanced in vitro and in silico modelling tools for the study of healthy and diseased neurons at the network level. The project thus aims to integrate cutting-edge morphogenetic neuroengineering and computational tools in an advanced modelling platform for the study and elucidation of key dynamics of ALS disease progression at the neural network level. Specifically, we aim to identify and extract key features of functional connectomes in motor neuron ensembles underlying the selective vulnerability of such networks to ALS-related pathology.

We are looking for a highly-motivated, enthusiastic, talented, creative scientist with a strong commitment to research. A strong theoretical and practical background in neurobiology and/or (neuro)computation, with special focus on plasticity, is recommended.

For more information and how to apply (

Job Information

Closing date:
The Norwegian University of Science and Technology (NTNU)
Faculty of Medicine and Health Sciences

Contact Information

Ioanna Sandvig
7491 Trondheim, Norway

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