Connecting European Neuroscience

Ph.D. Student in Marseille/France

13 April 2018

Ph.D. Student in Marseille/France

Job ID
18622
Place
Marseille/France

Description

Title: Anatomo-functionnal dissection of the neuronal networks driving respiratory rhythm generation and respiratory-cardiovascular entrainment.

The respiratory and cardiovascular systems work hand-in-hand to maintain blood gas homeostasis, which is critical for life. The activity of these systems is controlled and regulated centrally, by networks of neurons that are able to generate throughout life a rhythmic and patterned command. Any failure of these networks leads to severe condition and death, like in Sudden Infant Death Syndrome (SIDS) or Sudden Unexpected Death in Epilepsy (SUDEP). Many rare diseases are also affected, Prader-Willi Syndrome being the focus of our research team where newborns suffer from severe respiratory alterations of central origin that lead to death in 30% of cases. Despite critical physiological and pathological importance, crucial fundamental questions are still unanswered: how is the respiratory rhythm generated? How is the coupling between respiratory and cardiovascular neurons generated? We use exciting, state-of-the-art technology to answer these questions, with viral tracing for connectomic mapping, optogenetic and pharmacogenetic manipulation of neuronal activity, and calcium imaging for neuronal network activity recordings in vivo in freely moving animals.

This research project was selected as part of the 2018 Integrative and Clinical Neuroscience PhD Program in Marseille, France, which will grant 3 three-year PhD scholarships for students who validated a master’s from non-French universities. The call for application for students is now open, with a deadline on April 20th, 2018: http://neuro-marseille.org/en/phd-program-en/call-for-phd-applicants/
Further detail about this research project can be found in the list of selected projects for this call (project #10), by following the link above.

Job Information

Closing date:
2018-04-20
Contract length:
3 years
Institution:
Intitut de Neurobiologie de la Méditerranée

Contact Information

Clément Menuet
Equipe Neurodéveloppement et Syndrome de Prader-Willi : du gène à la thérapie
Inserm | Institut de Neurobiologie de la Méditerranée (INMED) UMR1249
163 Avenue de Luminy | BP13 | 13273 Marseille Cedex 09
Phone
+33(0)491828159
Email
clement.menuet@inserm.fr
Website
http://www.inmed.fr

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