Connecting European Neuroscience

Post-doctoral position in Rouen/France

17 August 2018

Post-doctoral position in Rouen/France

Job ID
19938
Place
Rouen/France

Description

This work project is based on team previous results showing that the vasoactive peptide urotensin II (UII) in subarachnoid hemorrhage patients may constitute a diagnostic marker of cerebral vasospasm, and that novel ligands of UII receptor prevent cerebral vasospasm in a subarachnoid mouse model. We are looking for a motivated post-doctoral fellow to investigate the cerebral vasospam and gliovascular consequences leading to neurobehavioral alterations of wild-type and transgenic hemorrhage mice. Specific neuroinflammatory processes will be assessed in vivo, through MPIO targeted against endothelial adhesion molecules for MRI (WP1 in Coll. Pr D. Vivien, Caen). At the molecular level, the aim is to understand endothelial cells integrity/EndMT transition and UII receptor signaling signature pathways activated by newly designed ligands, in vitro and in vivo (WP2). We ambition to propose therapeutic molecules targeting the UII receptor, to prevent post-hemorrhage deficits.

Job Information

Closing date:
2018-10-01
Employment start date:
2018-10-01
Contract length:
1 year (renewable 1 year)
Institution:
Institute for Research and Innovation in Biomedicine (IRIB)
Department:
INSERM U1239, Team Astrocyte and Vascular Niche

Contact Information

CASTEL Helene
Astrocyte and Vascular Niche, INSERM U1239,
Normandie Rouen University (URN), headed by Dr Hélène Castel, DR2 Inserm researcher, Institute for Research and Innovation in Biomedicine (IRIB), CURIB, 25 Rues Tesnière, 76 821 Mont-Saint-Aignan.

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