Connecting European Neuroscience

Post-doctoral position in St. Petersburg, Florida, USA/USA

10 October 2018

Post-doctoral position in St. Petersburg, Florida, USA/USA

Job ID
20396
Place
St. Petersburg, Florida, USA/USA

Description

The laboratory of Matthew Poy at the new Institute for Fundamental Biomedical Research at Johns Hopkins All Children's Hospital in St. Petersburg, Florida is seeking two post-doctoral fellows for a project on the characterization of the microRNA pathway in the regulatory role of the CNS in energy homeostasis.

The metabolic syndrome is characterized by obesity, hyperglycemia, and insulin resistance and alterations to both insulin and leptin signaling cascades can contribute to a pathogenic state. Previous studies by our group have shown that microRNAs are highly regulated in the pancreatic islets of insulin-resistant mouse models and in the islets of type 2 diabetic human subjects and play a key role in the growth and function of the pancreatic beta cell (Tattikota et al. Cell Metabolism, 2014). Many of the genes targeted by microRNAs in the endocrine pancreas are abundantly expressed in the CNS, suggesting these factors serve in a similar capacity across multiple tissues. In addition, the susceptibility to obesity is linked to genes regulating neurotransmission, pancreatic beta-cell function and energy homeostasis and we recently characterized the role of CADM1 and CADM2 in the regulation of body weight (Rathjen et al. Nature Neuroscience, 2017; Yan et al. Molecular Metabolism, 2018). Future aims are directed towards understanding the role of the microRNA pathway in the CNS in managing systemic energy metabolism and metabolic stress responses as well as elucidating its specific mechanisms of action.
Applicants must have an M.D. or Ph.D. in a relevant subject (i.e. Molecular Biology) and a publication history. Excellent organization and record-keeping skills, a meticulous approach to practical work, the ability to work effectively and flexibly as part of a team, and ability to plan and execute experimental research independently are required.
Interested applicants should provide a CV, a cover letter describing career goals, references and send to mpoy1@jhmi.edu.

Job Information

Institution:
Johns Hopkins All Children's Hospital
Department:
Institute for Fundamental Biomedical Research

Contact Information

Matthew Poy
600 6th Avenue South
IFBR, Rm 3110
Phone
7277674915
Email
mpoy1@jhmi.edu
Website
https://www.hopkinsallchildrens.org/

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