Connecting European Neuroscience

Post-doctoral position in Chicago/USA

04 November 2018

Post-doctoral position in Chicago/USA

Job ID
20633
Place
Chicago/USA

Description

Alzheimer's Disease: Cell biology / Advanced Microscopy / animal models

Two NIH-funded postdoctoral positions are available immediately for highly-motivated individuals to study molecular and cellular mechanisms of Alzheimer's disease pathogenesis. We investigate cellular and molecular mechanisms of pathogenesis and disease-associated synaptic abnormalities using neuronal and oligodendrocyte cell cultures, transgenic/knock-in/knock-out mouse models. A major focus of our research is to characterize using conditional KO and transgenic mice, the biological pathways and pathogenic mechanisms regulated by the major late-onset Alzheimer’s disease risk gene, BIN1. The second focus of our research is to understand the neuronal targeting mechanisms responsible for polarized sorting of the aspartyl protease BACE1, using advanced microscopy approaches.

Recent publications:
Buggia-Prévot et al. Cell Reports 5: 1552–1563, 2013.
Buggia-Prévot and Thinakaran. Bioessays. 37:888-98, 2015.
De Rossi et al. Mol Neurodegener. 2016, 11:59.
Andrew et al. Proc. Natl. Acad. Sci. USA. 2017, 114:E9665-E9674.

Successful applicants will have the opportunity to work in a dynamic environment and train with experienced molecular, cellular, and developmental neuroscientists investigating various aspects of the nervous system function and dysfunction.

Applicants must hold a Ph.D. or MD. Ph.D. in a related field, and a strong background in molecular and cellular biology, neurobiology, or animal models. Only candidates with previous experience in live-cell / super-resolution imaging, neuronal protein trafficking, oligodendrocyte biology, or mouse models of Alzheimer’s disease will be considered for this position. Preference will be given to candidates with interdisciplinary training and strong publication record.

Interested applicants should send their CV, statement of research interest, and the names of three referees.

The Univ of Chicago is an Affirmative Action/Equal Opportunity Employer.

Job Information

Employment start date:
2019-01-05
Contract length:
3 years
Institution:
The University of Chicago
Department:
Neurobiology

Contact Information

Prof. Gopal Thinakaran
Department of Neurobiology
The University of Chicago
Knapp R212, 924 East 57th Street
Chicago, IL 60637
U.S.A.
Phone
773-834-3752
Email
gopal@uchicago.edu
Website
https://thinakaranlab.uchicago.edu/

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