Connecting European Neuroscience

Post-doctoral position in London/UK

08 January 2019

Post-doctoral position in London/UK

Job ID


The UK Dementia Research Institute (UK DRI) at Imperial has been established to address a medical research area of the highest importance and future impact. As one of six new national centres of excellence embedded in major UK universities, we intend to transform the diagnosis, treatment and care of people with dementias. The Medical Research Council and charity partners the Alzheimer's Society and Alzheimer’s Research UK have invested £290m in fulfilment of the ambition identified in the Prime Minister's 2020 Challenge on Dementia. The fellowship programme of Dr Marco Brancaccio is focused on defining the mechanisms driving circadian dysfunction in the early stages of Alzheimer’s disease (AD). Sleep and circadian disturbances have been recently associated with the earliest preclinical manifestations of AD, in both humans and animal models of the disease. We will investigate the molecular, cellular and circuit mechanisms underlying this association, the genetic and environmental factors driving circadian dysfunction and their specific role in the AD pathogenesis. The long-term goal of this project is the development of novel therapeutic approaches aimed at recruiting circadian clocks in the brain for AD prevention/ early intervention. The UK DRI is seeking outstanding post-doctoral researchers interested in taking on a challenging role with considerable scope for independent scientific achievement and personal growth. The ideal candidate will be ambitious, with the passion to tackle big problems and a readiness to try out high-risk, high-payoff projects. Exceptional experience in viral vector technologies (AAVs, LVs), in vivo and ex vivo live imaging, stereotaxic surgery, in vivo micro-dialysis, mouse behaviour will be considered as an advantage. Experience in circadian and sleep research is also an advantage, but it is not strictly required

Job Information

Employment start date:
Contract length:
3 years
Imperial College London
Division of Brain Sciences, Dept of Medicine

Contact Information

Marco Brancaccio
Department of Medicine, E401 Burlington Danes Building Hammersmith Hospital Campus, Du Cane Road, London

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