Connecting European Neuroscience

Ph.D. Student in Sherbrooke/Canada

05 February 2019

Ph.D. Student in Sherbrooke/Canada

Job ID


TITLE: Dopaminergic control of brainstem locomotor circuits in mice.
PROJECT : The locomotor role of dopaminergic cells is classically attributed to their ascending projections to the basal ganglia that in turn project to the Mesencephalic Locomotor Region (MLR), a brainstem region that controls locomotion. However, direct descending projections to the MLR were uncovered (Ryczko et al. PNAS 2013, PNAS 2016, J Neurosci 2017, for review see Fougère et al. Curr Opin Physiol 2019). In lamprey, this descending pathway increases locomotor activity. In mammals, the role of such innervation remains to be determined. The student will address this issue using optogenetics, chemogenetics, patch-clamp electrophysiology, viral tracing, and behavioral assays in mice. The new knowledge will provide a better understanding of the relation between dopaminergic and brainstem neurons and help identify new clinical strategies to improve locomotor function in people with Parkinson’s disease.
REQUIREMENTS: The candidate must have completed a Master's degree in Neuroscience. An asset for the candidate would be to have experience in optogenetics, chemogenetics, electrophysiology or calcium imaging and an interest in locomotor control.
HOST LABORATORY: Dr. Ryczko has expertise in the neural control of locomotion in vertebrates and published his research in excellent journals (PNAS, Science, Journal of Neuroscience…). We receive grant support by the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC) and the Fonds de Recherche en Santé du Quebec (FRQS). We are equipped for i) in vivo optogenetics, chemogenetics and viral injections; ii) patch-clamp recordings and calcium imaging; iii) anatomical imaging (confocal, light-sheet, STED microscope).
APPLY: Candidates should send a letter of interest, a CV, a record of their academic results and two references at:

Job Information

Closing date:
Employment start date:
Contract length:
4 years
Université de Shebrooke
Département de Pharmacologie-Physiologie

Contact Information

Ryczko, Dimitri
Département de Pharmacologie-Physiologie
Université de Sherbrooke, 3001, 12e Avenue Nord

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