Connecting European Neuroscience

Ph.D. Student in Munich/Germany

04 June 2019

Ph.D. Student in Munich/Germany

Job ID
23508
Place
Munich/Germany

Description

Within the scope of the newly funded E-Rare consortium ‘MAXOMOD’, we offer a PhD student position (E13, 55%) to work on the identification of molecular determinants of motoneuron degeneration and the validation of diagnostic markers and therapeutic targets in Amyotrophic lateral sclerosis.
In the scope of the international MAXOMOD consortium (www.maxomod.uni-goettingen.de) we will analyze well-characterized human tissue and cerebrospinal fluid (CSF) samples and compare these with tissue from transgenic ALS mouse models. We will combine multiple analytic methods from genomics, transcriptomics and microRNAomics up to proteomics and metabolomics followed by multivariate semantic data integration to identify new disease-relevant pathways and biomarkers related to axono-synaptic pathology. The data will be made available to other researchers on the FAIR-ALS platform. These novel molecular targets will be validated in vitro, in vivo as well as in CSF from ALS patients from a clinical trial cohort. A small-molecule library with known and experimental pharmacological compounds from a large pharmaceutical company will be available for validation of therapeutic targets.
We are looking for a PhD candidate, who will work in our lab in Munich with a keen interest for translational neuroscience research and excellent background in cellular and molecular neurobiology. Enthusiasm for research and an extraordinary motivation to work in a multidisciplinary environment as part of an international consortium are key. Methods will include preparation of human brain and CSF samples for multiomic analyses, primary neuronal cell culture, microscopy, therapeutic interventions in ALS mouse models in vivo, histology, behavioral analyses, bioinformatic data integration. The successful candidate should have FELASA Cat. B. The candidate will be supervised by the PI and a post-doctoral fellow.

Job Information

Closing date:
2019-07-30
Employment start date:
2019-11-01
Contract length:
3 years
Institution:
Technical University Munich
Department:
Department of Neurology

Contact Information

Prof. Dr. Paul Lingor
Ismaninger Straße 22
81675 München
Germany

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