Connecting European Neuroscience

PhD position in Heidelberg/Germany

08 July 2019

PhD position in Heidelberg/Germany

Job ID
23883
Place
Heidelberg/Germany

Description

Project Title and description:

Functional roles and mechanisms of post-translational modifications (PTM) in diabetic peripheral neuropathy (DPN)

Summary

PTM constitute a key mode of regulation of protein function and localization in biological processes. Diabetes is manifest with an increase in the levels of ROS, methylglyoxal (MG) and glyoxal (GL). ROS, produced during metabolic stress, hyperglycemia, etc., directly regulates PTM of target proteins. In this project, we aim to investigate the changes in proteomes and alteration in PTM of proteins in Schwann cells and peripheral neurons at different diabetic stages to understand the modulation of axonopathy by Schwann cell dysfunction in progression of DPN. You will identify and characterize the novel metabolic target(s) of PTM and their impact on the metabolic pathways.

Methods that will be used:

Standard molecular biology techniques, protein biochemistry, quantitative fluorescence microscopy, rodent behavioral assay, advance in vitro methods to study neuronal and Schwann cell interactions.

Cooperation partners:

We have both national and international partners.

Qualifications:

It is expected that the candidate should be highly motivated to conduct competitive research at the interface of biochemistry, molecular biology and behavioral studies. Experience in biochemistry, molecular biology and animal handling is preferred.

Job Information

Closing date:
2019-08-15
Employment start date:
2019-10-01
Institution:
Heidelberg University
Department:
Institute of Pharmacology

Contact Information

Dr. Nitin Agarwal
Institute of Pharmacology,
INF 366, Heidelberg University
69120 Heidelberg

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