Connecting European Neuroscience

PhD position in Mannheim/Germany

08 July 2019

PhD position in Mannheim/Germany

Job ID
23885
Place
Mannheim/Germany

Description

Project Title and description:
Optogenetic tools to explore the role of GABA in modulating pre-synaptic and axonal signalling in peripheral C-fibre nociceptors

A reduction in inhibitory control within the spinal dorsal horn is widely implicated in the development of chronic pain. Accordingly, restoration of spinal inhibition offers a rational and attractive therapeutic strategy. However, the substrates of spinal inhibitory circuits and the mechanisms underlying their disinhibition remain open questions. This project sets out to identify which functional classes of primary afferent C-fibre nociceptors are amenable to pre-synaptic modulation by virtue of their expression of axonal GABA-A receptors.

Klein et al (2017) JNeurosci, 37, 5204-5214
Sittl et al (2012) PNAS, 109, 6704-9
Carr et al (2010) PlosONE, 5, e8780

Methods: Chloride imaging, single fibre electrophysiology, corneal nerve terminal electrophysiology, optogenetic neural modulation, numerical simulations in silico

Applicant: Undergraduates from the life sciences, mathematics, physics, engineering or medicine with an interest in optical tools and their application to biological problems. Training for all techniques will be provided during the candidature including technical courses and FELASA accreditation.

Funding: This project is supported by the second funding period of the Heidelberg Pain Consortium SFB1158 (www.sfb1158.de)

Job Information

Closing date:
2019-10-01
Employment start date:
2020-01-01
Institution:
Medical Faculty Mannheim, Heidelberg University
Department:
Experimental Pain Research

Contact Information

Dr. Richard Carr
Experimental Pain Research
Medical Faculty Mannheim, Heidelberg University
Ludolph-Krehl-Str. 13-17, 68167 Mannheim

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