Connecting European Neuroscience

PhD position in Mannheim/Germany

08 July 2019

PhD position in Mannheim/Germany

Job ID
23888
Place
Mannheim/Germany

Description

Project Title and description: Role of the neurovascular unit in pain-induced spinal sensitization

This project is focused on understanding the alterations that may occur in the neurovascular (NVU) unit during conditions of chronic pain. We aim to elucidate whether cellular interactions, or the molecular signalling, within the NVU are altered in the context of chronic pain.

Based on Prof. Mauceri’s previous findings, this project also aims to elucidate whether alterations in the neurovascular unit result in the observed pain-associated epigenetic changes in spinal cord neurons.

The recruited student for Ruiz de Almodóvar’s group will focus on understanding the changes in the NVU using different transgenic mouse lines and approaches.

The epigenetic part of the project will be performed by Prof. Mauceri’s team.

The recruited student will be part of the group of Carmen Ruiz de Almodóvar, who will be the supervisor of the PhD student.

Own key publications (3):

Karakatsani A , Shah B, Ruiz de Almodovar C. Blood vessels as regulators of neural stem cell properties. Front Mol Neurosci. 2019. Apr 12

Paredes I, Himmels P, Ruiz de Almodóvar C. Neurovascular Communication during CNS Development. Dev Cell. 2018 Apr 9;45(1):10-32.

Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET & Ruiz de Almodovar C. Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun. 2017 Mar 6;8:14583.

Key words for methods that will be used: mouse genetics; in vivo mouse work; histology; high resolution microscopy; molecular biology; biochemistry.

Desired profile of an applicant: Highly motivated student willing to work in a dynamic international environment.

Background in neuroscience, cellular biology and/or biochemistry.

Funding: This project is supported by the second funding period of the Heidelberg Pain Consortium SFB1158 (www.sfb1158.de)

Job Information

Closing date:
2019-08-15
Employment start date:
2019-10-01
Institution:
Faculty of Medicine Mannheim, University of Heidelberg
Department:
Dept. Vascular Dysfunktion, European Center for Angioscience (ECAS), Institute for Transfusion Medicine/Immunology

Contact Information

Prof. Dr. Carmen Ruiz de Almodóvar
Dept. Vascular Dysfunktion
European Center for Angioscience (ECAS)
Institute for Transfusion Medicine/Immunology
Faculty of Medicine Mannheim
University of Heidelberg
Ludolph-Krehl-Str. 13-17
D-68167 Mannheim

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