Connecting European Neuroscience

Post-doctoral position in Tampa/USA

16 July 2019

Post-doctoral position in Tampa/USA

Job ID
23953
Place
Tampa/USA

Description

NIH funded postdoctoral positions are available immediately to highly motivated individuals to participate in ongoing studies on Alzheimer's disease (AD). Our laboratory is focusing on the pathophysiological function of Amyloid Precursor Protein (APP). We recently established that APP-mediated signaling could have profound consequences on brain plasticity and rescue memory decline in AD mouse models. We identified an interaction between APP intracellular domain and the heterotrimeric G-protein subunit that affects axodendritic outgrowth in AD mouse models. To complement our ongoing investigations, we seek to understand whether the impaired cognition associated with sleep perturbations underlies a function of APP and its metabolites using well-characterized mouse models of AD.

Relevant publications:
Deyts et al., Journal of Neuroscience, 2012. doi: 10.1523/JNEUROSCI.5433-11.2012
Deyts, Thinakaran, & Parent, Trends in Pharmacological Sciences, 2016. doi: 10.1016/j.tips.2016.01.005
Deyts et al., eLife, 2016. doi: 10.7554/eLife.15645
Deyts et al., Cell Reports, 2019. doi: 10.1016/j.celrep.2019.03.087

Applicants must hold a Ph.D. or MD. Ph.D. in a related field, and a strong background in neurobiology, molecular/cellular biology, or mouse behavior. The candidate should have a keen interest in understanding complex mechanisms underlying memory formation and storage in mouse models of Alzheimer’s disease. Previous experience in sleep architecture, cognitive behavior, synaptic physiology, cell culture system, brain expression of viral proteins, confocal imaging or optogenetic will be an asset.

Successful applicants will have the opportunity to work in a dynamic environment and train with experienced molecular, cellular, developmental, and behavior neuroscientists investigating various aspects of the nervous system.

Positions available for up to 3-5 years. Interested applicants should send their CV, statement of research interest, and names of three referees.

Job Information

Employment start date:
2019-08-01
Institution:
University of South Florida
Department:
Molecular Medicine - Neuroscience Institute - Byrd Alzheimer’s Center

Contact Information

Dr. Angèle Parent
Neuroscience Institute - Byrd Alzheimer’s Center
Department of Molecular Medicine
The University of South Florida
4001 E Fletcher Ave
Tampa, FL 33613

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