Connecting European Neuroscience

Ph.D. Student in Lübeck/Germany

04 September 2019

Ph.D. Student in Lübeck/Germany

Job ID
24352
Place
Lübeck/Germany

Description

The researchers in the DFG-funded Graduiertenkolleg 1957 in Lübeck study the effects of adipose tissue hormones on CNS function and in turn, the control of adipose tissue physiology by the brain. We are looking for highly motivated candidates for the following project.
Tentative start: May 2020. Earlier start date could be discussed with the PIs in the interview.

PhD Position in TRH neurons in the energy homeostasis and regulation of brown adipose tissue

Project Description:
Regulation of the thermogenesis mediated by the uncoupling protein 1 (UCP1) is the specific metabolic function of brown (BAT). The central administration of thyroid releasing hormone (TRH) increases the body temperature and BAT activity. In the central nervous system the TRH neurons and the TRH-receptors are widely distributed. However, the neurological pathways in the regulation of body temperature and BAT activity is still unknown. In this project, we want to clarify these pathways using transgenic mouse models in combination with recombinant adeno associated viral vectors.

Experimental Methods:
Working with genetically modified mice (knock-out mice), including breeding strategies
Generation, production and icv application of rAAV vectors
Phenotyping of mice including measurement of thermogenesis, energy expenditure and body weight
Immunohistochemical analyses of TRH neurons and their projections
DNA, mRNA, protein extraction and quantification

Qualifications:

Research-based master's degree or equivalent (e.g. diploma) passed with an excellent grade in biology, biochemistry, molecular life science, neuroscience, nutrition & biomedicine, pharmacology or a related subject

Excellent English language skills in speaking and writing

Pro-active attitude, good communication skills and ability to work independently in an interdisciplinary team

Apply here: https://www.grk1957.uni-luebeck.de/grk-1957/phd-positions-on-adipocyte-brain-crosstalk.html

Job Information

Closing date:
2019-10-30
Employment start date:
2020-05-01
Contract length:
3 years
Institution:
University of Lübeck, GRK1957 "Adipocyte-Brain Crosstalk"
Department:
Institute of Neurobiology

Contact Information

Julia Steinhardt
Ratzeburger Allee 160

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