Connecting European Neuroscience

Ph.D. Student in Lübeck/Germany

04 September 2019

Ph.D. Student in Lübeck/Germany

Job ID
24355
Place
Lübeck/Germany

Description

The researchers in the DFG-funded Graduiertenkolleg 1957 in Lübeck study the effects of adipose tissue hormones on CNS function and in turn, the control of adipose tissue physiology by the brain. We are looking for highly motivated candidates for the following project.
Tentative start: May 2020. Earlier start date could be discussed with the PIs in the interview.

PhD Position in The role of the SCN clock in the regulation of leptin signaling in the brain

Project Description:
In mammals, a master circadian clock in the suprachiasmatic nucleus (SCN) synchronizes different central and peripheral tissue clocks to organize physiology and behavior across the 24-h day cycle. The adipokine hormone leptin is a major regulator of appetite and energy expenditure, acting via hypothalamic circuits. In obesity the brain becomes leptin resistant while at the same time circadian rhythms become disrupted. We hypothesize that circadian coordination of SCN-derived and feeding state-related signals determines the efficiency of leptin signaling to the brain, thus shielding the brain from a loss of leptin sensitivity and preserving its weight-controlling function under high-fat diet conditions.

Experimental Methods:
Working with genetically modified mice (knock-out mice), including breeding strategies
Phenotyping of mice including measurement of sleep-wake behavior, food intake, thermogenesis, energy expenditure and body weight
Organotypic slice cultures with long-term luminescence recordings
Immunohistochemical analyses
DNA and RNA extraction
PCR, qPCR, in-situ hybridization

Qualifications:

Research-based master's degree or equivalent (e.g. diploma) passed with an excellent grade in biology, biochemistry, molecular life science, neuroscience, nutrition & biomedicine, pharmacology or a related subject

Excellent English language skills in speaking and writing

Pro-active attitude, good communication skills and ability to work independently in an interdisciplinary team

Apply here: https://www.grk1957.uni-luebeck.de/grk-1957/phd-positions-on-adipocyte-brain-crosstalk.html

Job Information

Closing date:
2019-10-30
Employment start date:
2020-05-01
Contract length:
3 years
Institution:
University of Lübeck, GRK1957 "Adipocyte-Brain Crosstalk"
Department:
Institute of Neurobiology

Contact Information

Julia Steinhardt
Ratzeburger Allee 160

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