Connecting European Neuroscience

Ph.D. Student in Erlangen/Germany

10 October 2019

Ph.D. Student in Erlangen/Germany

Job ID
25641
Place
Erlangen/Germany

Description

The group of Prof. Christian P. Müller at the Psychiatric and Psychotherapeutic Clinic of the University Hospital Erlangen-Nuremberg (FAU) offers a PhD position with a thematic focus on the study of the effects and loss of efficacy of antipsychotic drugs in the treatment of schizophrenia. The project investigates how the observed accumulation of different antipsychotics in cellular vesicles during treatment (Tischbirek et al., Neuron, 2014) leads to the often observed loss of efficacy of the therapy and how to prevent it. By means of various non-accumulating substance analogues, a rat model of schizophrenia will be used to investigate how the accumulation of antipsychotics first leads to therapeutic effects over several symptom dimensions (psychosis, emotionality and cognition) (Uzuneser et al., Eur. Neuropsychopharm. 2018). Furthermore, we will measure how the accumulation develops after chronic administration and which of the subsequent cellular adaptation processes leads to the loss of efficacy in each symptom dimension. Thereafter, new therapeutic interventions are to be tested, which can specifically prevent the loss of efficacy (Amato et al., Molecular Psychiatry, 2018). Our laboratory has in-depth expertise in neurochemical, behavioral and molecular biology techniques related to the study of schizophrenia in animal models, as well as a long history in the study of the effects of neurochemical interventions. The project offers membership and education at the FAU Graduate School Life@FAU with all its benefits. We are looking for an enthusiastic scientist with a background in behavioral neuroscience, biochemistry, molecular medicine, psychology, biology or physiology who is interested in an animal experimental approach. Applicants are requested to send a copy of their curriculum vitae, a publication list, a statement on research interests and a letter of recommendation to Christian P. Müller (christian.mueller@uk-erlangen.de) by e-mail.

Job Information

Closing date:
2019-11-15
Employment start date:
2019-12-15
Contract length:
36 month
Institution:
Friedrich-Alexander-University of Erlangen-Nuremberg
Department:
Department of Psychiatry and Psychotherapy

Contact Information

Prof. Christian P. Müller
Department of Psychiatry and Psychotherapy
Friedrich-Alexander-University Erlangen-Nuremberg
Schwabachanlage 6
91054 Erlangen
Germany
Phone
+49-(0)9131-85-36896
Email
christian.mueller@uk-erlangen.de

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