Connecting European Neuroscience

Ph.D. Student in Regensburg/Germany

07 November 2019

Ph.D. Student in Regensburg/Germany

Job ID
25863
Place
Regensburg/Germany

Description

Project: “Molecular pathomechanisms associated with major depressive disorder (MDD)”

Major depressive disorder (MDD) is a severe mental disorder affecting 350 million people worldwide. The molecular mechanisms underlying the cause and the progress of this complex disease are still not completely understood. To search for and characterize molecular pathomechanisms associated with MDD, we use skin fibroblasts as well as induced pluripotent stem cells and induced neurons (iNeurons), which were derived and reprogrammed from depressed patients or healthy controls. By comparing functional parameters in depressed vs. control iNeurons, we investigate the bioenergetic capacity, intracellular signaling pathways, and neuronal communication by means of respirometry and live cell imaging (calcium imaging, voltage-sensitive dyes), as well as molecular, pharmacological and electrophysiological (patch-clamp) approaches.

Start of funding on March 1st, 2020. Position is funded for up to three years, according to the German pay scale TV-L E13 (65%). The project is part of the DFG graduate program “Neurobiology of emotion dysfunctions” GRK 2174 (https://www.uni-regensburg.de/research/grk-emotion/)

Prof. Dr. Christian Wetzel, AG Molecular Neurosciences, Department of Psychiatry and Psychotherapy, University of Regensburg
Christian.Wetzel@ukr.de

https://www.uni-regensburg.de/medizin/psychiatrie-psychotherapie/forschung/molekulare-neurowissenschaften/index.html

Job Information

Employment start date:
2020-03-01
Contract length:
3 years
Institution:
University of Regensburg
Department:
Psychiatry and Psychotherapy

Contact Information

Christian Wetzel
Molekulare Neurowissenschaften
Lehrstuhl für Psychiatrie und Psychotherapie
Fakultät für Medizin
Universität Regensburg

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