Connecting European Neuroscience

Post-doctoral position in Gothenburg/Sweden

10 January 2020

Post-doctoral position in Gothenburg/Sweden

Job ID
26347
Place
Gothenburg/Sweden

Description

POST-DOC IN MOLECULAR NEUROSCIENCE
- Focus on experimental genetics in cultured human neurons

We are interested in understanding – on a molecular level - how synaptic connections between neurons are formed and how impairments in synaptic functions may contribute to human disease. To address these fundamental questions, we combine mouse genetics and gene-edited human neurons with functional assays and protein biochemistry and proteomics.

The position will provide the applicant opportunities to engage in one or both of the following projects:

- Address how genetic variants, identified in patients with developmental delay, intellectual disabilities and/or autism, may impair cellular functions to cause disease. To this end, CRISPR/Cas9 and adeno-associated virus (AAV) will be used to introduce specific mutations in human embryonic stem cells (ESCs) or correct patient-derived induced pluripotent cells (iPSCs).

- Study mechanisms of synapse formation, using abovementioned cultured human neurons as a reductionist system for synapse formation. Using this system, the specific role of glycosaminoglycans will be addressed. Several proteins involved in the assembly and function of synapses are proteoglycans, but it remains largely unknown to what extent the carbohydrate chains and their composition contribute to synaptic diversity and specificity.

We invite applications from enthusiastic and motivated individuals with a PhD in a relevant field. Applicants preferably have a strong background in molecular biology and/or neuroscience. Experience in experimental techniques relevant for the project is advantageous but not an absolute requirement.


For more information and to apply, please visit
https://www.gu.se/english/about_the_university/job-opportunities/vacancies-details/?id=5340

Job Information

Closing date:
2020-01-26
Contract length:
12+12 months
Institution:
University of Gothenburg
Department:
Biomedicine

Contact Information

Fredrik Sterky
Bruna Straket 16
41345 Gothenburg
Sweden

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