Connecting European Neuroscience

Ph.D. Student in Innsbruck/Austria

21 January 2020

Ph.D. Student in Innsbruck/Austria

Job ID
26447
Place
Innsbruck/Austria

Description

Calcium channels in congenital stationary night blindness

Photoreceptors are morphologically and physiological highly specialized light sensing cells of the retina where sustained release of glutamate from ribbon synapses is calcium dependent and L-type calcium channels (LTCC) serve as the predominant source for Ca2+ entry. Mutations in the CACNA1F gene encoding Cav1.4 LTCCs were identified among patients diagnosed with congenital night blindness type 2 (OMIM: 30071). Ongoing work investigates the pharmaco-therapeutic potential of retinal Cav1.4 LTCCs.

Methods: Immunohistochemical and functional analyses in isolated retinal neurons, retinal whole-mounts and slices; cell culture; retinal AAV gene-therapy.

References: Knoflach et al. (2015) Channels (Austin) 9(5):298-306; Seitter and Koschak (2018) Neuropharmacology 132:58-70. (Review); zur Nedden et al. (2018) J. Clin Invest; Pangrsic et al. (2018) Physiol Reviews (Review).

Salary: According to the rates of the Austrian Science Fund (FWF) for PhD students plus travel funds for international scientific meetings.

Contact: Ao. Univ. Prof. Alexandra Koschak, University of Innsbruck, Institute of Pharmacy, Pharmacology and Toxicology, Innrain 80/82, 6020 Innsbruck, Austria
E-mail: Alexandra.Koschak@uibk.ac.at Tel.: +43-(0)512-507 - 58807

More information and application: The successful candidate will be part of the Neuroscience PhD program CavX-Calcium channels in excitable cells:
https://phd-school.i-med.ac.at/phd-programs/doctoralprogram/neuroscience/
http://www.uibk.ac.at/pharmazie/pharmakologie/koschak.html

Job Information

Closing date:
2020-02-14
Institution:
University of Innsbruck

Contact Information

Alexandra Koschak
Ao. Univ. Prof. Alexandra Koschak
Universität Innsbruck
Institut für Pharmazie
Pharmakologie und Toxikologie
Center for Chemistry and Biomedicine
Innrain 80 - 82/III
A-6020 Innsbruck
Austria

Jobs Archive

loading