Connecting European Neuroscience

Ph.D. Student in Basel/Switzerland

22 January 2020

Ph.D. Student in Basel/Switzerland

Job ID


The Position
The RiSE program (Roche Internships for Scientific Exchange) is a highly competitive student research program at Roche. It offers the most talented postgraduate PhD and medical degree students the opportunity to be fully integrated into our interdisciplinary and international industry R&D environment. As a RiSE student you will enhance your competencies, gain valuable work experience with us, and eventually become part of a world-wide network of RiSE Alumni.

The Neuroscience and Rare Diseases Discovery and Translational Area (NRD DTA) is developing medicines for a range of serious neurological diseases, including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, autism, spinal muscular atrophy, and Huntington’s disease.

As RiSE student in the NRD DTA you will join our Neurovascular biology group within the Neuroimmunology/Degeneration Section and work in close collaboration with the Cellular assays groups both of which are located at the Roche Innovation Center Basel, Switzerland. The aim is to isolate pure and intact lysosomes from macrophages/microglia differentiated from human induced pluripotent stem cells with monogenetic Parkinson’s disease background we have previously demonstrated have cellular phonotypes. The isolated lysosomes will be characterized by proteomic and lipidomic analysis. In addition, lysosome function will be modulate ,for example by modulating TFEB function , to determine if that can rescue both cellular and molecular disease phenotyps. You will be hosted and mentored by a Roche scientist and two postdocs who will guide you through your research and provide you with the needed work infrastructure and collaborative network.This work can contribute towards a pHD project.

Job Information

Employment start date:
Contract length:
9 months
F. Hoffmann-La Roche AG

Contact Information

F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel

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