Connecting European Neuroscience

Ph.D. Student in Sherbrooke/Canada

16 September 2020

Ph.D. Student in Sherbrooke/Canada

Job ID
27723
Place
Sherbrooke/Canada

Description

TITLE: Development of new antiparkinsonian drugs in mice.

PROJECT: The goal of this project is to develop new molecules able to dissolve alpha-synuclein aggregates to reduce dopaminergic cell degeneration and improve locomotor function in a mouse model of Parkinson’s disease. The student will develop an in vivo model of Parkinson’s disease based on viral injections in mice. The student will examine the effects of these new molecules on alpha-synuclein clusters in the brain, evaluate the degeneration of dopaminergic cells using immunofluorescence, and precisely measure their locomotor effects using machine-learning based analysis of video recordings. The knowledge will directly contribute to drug development in collaboration with a local team of chemists (Y Dory), a local team of neuropharmacologists (L Gendron) and a team of in silico modeling of molecular interactions (B. Champagne, Belgium). The student will be under the supervision of D. Ryczko and will have L. Gendron as co-supervisor.

REQUIREMENTS: The candidate must have completed a Master's degree in neuroscience. An asset for the candidate would be to have experience with virus injections in mice, behavioural assays, neuroanatomy, matlab scripting, and an interest in the interactions in locomotor control.

HOST LABORATORY: Dr. Ryczko has expertise in the neural control of locomotion in vertebrates and published his research in excellent journals (PNAS, Science, Journal of Neuroscience…). We receive grant support by the Fédération Wallonie Bruxelles - FRQ et FRS-FNRS, CIHR, NSERC, FRQS and CFI. We are equipped for i) in vivo optogenetics and viral injections; ii) patch-clamp recordings and calcium imaging; iii) microscopy (confocal, light-sheet, two-photon, STED); iv) high speed kinematics coupled with machine learning.

APPLY: Candidates should send a letter of interest, a CV, a record of their academic results and two references at: dimitri.ryczko@usherbrooke.ca.

Job Information

Closing date:
2020-10-31
Employment start date:
2021-01-04
Contract length:
4 years
Institution:
Université de Sherbrooke
Department:
Pharmacology-Physiology

Contact Information

Dimitri Ryczko
Département de Pharmacologie-Physiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke
3001, 12e Avenue Nord

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