Connecting European Neuroscience

Post-doctoral position in Munich/Germany

17 November 2020

Post-doctoral position in Munich/Germany

Job ID
27982
Place
Munich/Germany

Description

In the research group “Stress Resilience” we use various mouse stress models in combination with genetic or pharmacological manipulations to unravel the molecular, genetic and circuit-level underpinnings of individual stress resilience and the vulnerability to stress-related disorders.
There is a high co-morbidity of metabolic disorders as obesity and type 2 diabetes (T2D) with stress and stress-related disorders and we have recently uncovered that the psychiatric risk factor FKBP51 is also centrally involved in metabolic regulation. In this fully funded project we are now testing newly developed FKBP51 inhibitors (in collaboration with Felix Hausch from the University Darmstadt) as novel lead compounds for the treatment of metabolic disorders.

The successful applicant will be responsible for the in-vitro and in-vivo test of the newly
developed FKBP51 inhibitors. Using cellular as well as mouse models (e.g. diet-induced obesity, genetic mouse models) the FKBP51 inhibitors will be tested for efficacy, pharmacokinetic, pharmacodynamic and off target profiles in a dose- and time-dependent manner. PD efficacy will be confirmed against active positive control groups. At the end of this project we expect to have identified a lead compound with a full product profile that will allow first in human clinical trials.

Further information and the link to the application web page can be found here:

https://haufebewerbermanagement-2445.de.umantis.com/Vacancies/799/Description/2

Job Information

Employment start date:
2021-01-01
Contract length:
3 years
Institution:
Max Planck Institute of Psychiantry
Department:
Neurobiology of Stress Resilience

Contact Information

Mathias Schmidt
Max Planck Institute of Psychiatry
RG Neurobiology of Stress Resilience
Kraepelinstr 2-10
80804 Munich
Germany

Jobs Archive

loading