Connecting European Neuroscience

Ph.D. Student in VALBONNE/France

03 May 2021

Ph.D. Student in VALBONNE/France

Job ID
28811
Place
VALBONNE/France

Description

We are looking for a talented PhD student to investigate the impact of a Fragile X missense mutation in glutamate receptor trafficking. We recently demonstrated that FMRP is sumoylated in vivo and that its activity-dependent sumoylation is critical to the neuronal function. Sumoylation is the covalent conjugation of the Small Ubiquitin-like MOdifier (SUMO) protein to lysine residues of target proteins. It modulates the dynamics of multi-protein complexes. Several FXS missense mutations lead to amino-acid changes that are close to the active SUMO sites of FMRP. This raises the exciting possibility that these mutations directly affect the regulation of FMRP sumoylation, impacting its function, and consequently leading to FXS. We focused on the recurrent FXS R138Q mutation, which is close to the main active SUMO site of FMRP. We generated a Knock-in mouse model expressing the FXS R138Q mutation in FMRP (R138Q-KI). We published that the density of dendritic spines is increased with critical alterations in the surface levels of glutamatergic AMPA receptors (AMPAR) leading to significant synaptic plasticity defects and to impaired cognitive and social behaviours. The selected student will use biochemical and cell-imaging techniques to unravel the molecular basis of these receptor trafficking defects.

Contact: martin@ipmc.cnrs.fr
Application via: https://bit.ly/3dwLrAV

Job Information

Closing date:
2021-06-10
Employment start date:
2021-10-01
Contract length:
36 months
Institution:
Institut de Pharmacologie Moléculaire et Cellulaire (IPMC)
Department:
CNRS UMR 7275 - Université Côte d'Azur

Contact Information

Stéphane Martin
660 Route des Lucioles
Phone
0033 4 9395 3461
Email
martin@ipmc.cnrs.fr
Website
http://www.ipmc.cnrs.fr

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