Connecting European Neuroscience

Richard Brown

History Committee Member (2018 - 2022)

Curriculum Vitae

Professional and academic career

2013-2014.  Visiting Professor, Wolfson College, Oxford.

2010-2011. President, International Behavioural and Neurogenetics Society (IBANGS),

2008-2009. Senior Visiting Research Professor, St. John's College, and the Department of Psychology, University of Oxford, UK.

2002-2008. Chairman, Psychology Department, Dalhousie University.

1998-199. President, Canadian Society for Brain, Behaviour and Cognitive Science.

1997-1999. Director, Neuroscience Institute, Dalhousie University.

1996-1997. Chairman, NSERC of Canada Psychology Grants Committee (GSC12).

1992-1993. Visiting Fellow, School of Psychology, University of New South Wales, Australia. 

1988- present.  Professor, Department of Psychology, Dalhousie University.

1983-1988. Associate Professor, Department of Psychology, Dalhousie University,

1985-1986. Visiting Research Fellow, MRC Unit on the Development and Integration of Behaviour, Sub-department of Animal Behaviour, Cambridge University,

1978-1983. Assistant Professor, Department of Psychology, Dalhousie University,

1976-1978. Post-doctoral fellow in Zoology, University of Oxford, England 

1972-1975. PhD Student in Psychology and Physiology, Dalhousie University, Canada.


Honours and awards
 

2017.  Fellow of the Canadian Society for Brain, Behaviour and Cognitive Science.

2012. Dalhousie Association of Psychology Students (DAPS) Professor of the Year Award.

2009-2014. University Research Professor, Dalhousie University.

2008-2009. The Senior Visiting Research Professor, St. John's College, Oxford University. 

2006. Faculty of Science Award for Teaching Excellence,  Dalhousie University. 

2002-2007. Faculty of Science, Killam Research Professor Award. 

2002. Undergraduate Neuroscience Society, Dalhousie University. Award for Contributions to the Neuroscience Honours Program.


Research interests

The main research focus of our lab is the behavioural characterization of transgenic mice. This research uses an ethological and a multiple memory systems approach to understand the effects of genetic manipulation and environmental effects on cognitive function in mouse models of human neurological disease. Our research aims to define the neuro-behavioural changes in genetically modified mice, and relate these changes to strain differences in genes, their patterns of expression, and their effect on neural and behavioural changes throughout the lifespan. We are currently testing two models of Autism and two mouse models of Alzheimer Disease using developmental and Mouse IQ test batteries that we have developed in the lab. These test batteries are a set of standardized tests that include the measurement of sensory abilities such as vision, hearing and olfaction and higher order behaviours such as learning, memory, anxiety and social behaviours. By defining the optimal research protocols for determining the lifespan psychobiological changes in the behavioural phenotypes of these mouse models of human disease we are able to test the efficacy of novel compounds on both behavioural and neurohistological measures. I am also interested in the History of Neuroscience and teach a course on this.


Selected Publications

1. Kane AE, Shin S, Wong AA, Fertan E, Faustova, N., Howlett, SE, and Brown RE.  Sex differences in healthspan predict lifespan in the 3x Tg-AD mouse model of Alzheimer's Disease.  Frontiers in Aging Neuroscience, June 2018,  Volume 10,  Article 172. 

2. King, J.L., Wong, AA, and Brown, RE.   Age-related changes in the spatial frequency threshold of male and female 3xTg-AD mice using OptoMotry.  Journal of Alzheimer's Disease, 2018, 62, 591-596.

3. Brown, RE, Molnar, Z, Filaretova, L, Ostrovskiy, MA, Piccolino, M,  Lorusso, L.  The 100th anniversary of the Russian Pavlov Physiological Society.  Physiology,  2017, 32, 402-407.  PMID: 28978630

4. Brown, R.E. and Bolivar, S. The importance of behavioural bioassays in neuroscience. Journal of Neuroscience Methods, 2018. 300, 68-76.

5.  Rae, E.A. and Brown, R.E. The problem of genotype and sex differences in life expectancy in transgenic AD mice. Neuroscience and Biobehavioural Reviews, 2015, 57, 238-251.

6. O'Leary, T.P., Shin, S., Fertan, E., Dingle, R.N., Almuklass, A., Gunn, R.K., Yu, Z., Wang, J., and Brown, R.E.  Reduced acoustic startle response and peripheral hearing loss in the 5XFAD mouse model of AD. Genes Brain and Behaviour, 2017, 16, 554-563.

7. O’Leary, T.P., Robertson, A., Chipman, P.H., Rafuse, V.F. and Brown, R.E. Motor function deficits in the 12 month-old 5xFAD mouse model of AD. Behavioural Brain Research, 2018. 337, 256-263.

8. Stover, K.R., Campbell, M.A., Van Winssen, C.M., and Brown R.E. Early detection of cognitive deficits in the 3xTg mouse model of AD. Behavioural Brain Research, 2015, 289, 29-38.

9. Wilkinson, M. W. and Brown, R.E.   An Introduction to Neuroendocrinology, 2nd edition. Cambridge University Press, June, 2015. 479 pages.

10. Schellinck, H.M., Cyr, D.P., and Brown, R.E. How many ways can mouse behavioral experiments go wrong? Advances in the Study of Behavior, 2010, 41, 255-366.

11. Molnar, Z. and Brown, R.E. Insights into the life of Sir Charles Sherrington. Nature Reviews Neuroscience, 2010, 11, 429-436. 

12. Brown, R.E. and Milner, P.M.  The legacy of Donald O. Hebb: more than the Hebb synapse. Nature Reviews Neuroscience, 2003, 4, 1013-1019.

Professor Richard E. Brown, PhD

Professor Richard E. Brown, PhD
Department of Psychology
and Neuroscience
Dalhousie University
Halifax, Nova Scotia
CANADA, B3H 4R2

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