Connecting European Neuroscience

Trevor Bushell

Host Society Committee Chair (2018-2020)

Programme Committee Member FENS Forum 2020

CURRICULUM VITAE

1989-1993 B. Sc. (Hons) Pharmacology, Upper Second Class, University of Glasgow.

1993-1996 Ph. D. Neuroscience, University of Bristol

1996-1997 Post-doctoral Research Assistant, Dept. Anatomy, University of Bristol. 1997

1999 Wellcome International Research Fellow, Dept. of Physiological & Pharmacological Sciences, University of Chicago, USA

2000 Wellcome International Research Fellow, Dept. Biophysics, Imperial College London.

2001-2002 Post-doctoral Research Assistant, , Dept. Biophysics, Imperial College London.

2002-2011 Glaxo-Jack Research Lecturer in Drug Discovery, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde.

2011-present Senior Lecturer, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde.

GENERAL ADMINISTRATIVE AND ORGANISATIONAL EXPERIENCE

2009-present: Member and Strathclyde local group representative of the British Neuroscience Association (BNA).

2010-2015: BNA Council member and Local Groups co-ordinator.

BNA Festival of Neuroscience Program Committee (2013, 2015, 2017 & 2019)

Glasgow Neuroscience Day co-organiser: 2011 – present

Director of SIPBS Graduate School: 2011 - 2014

 

RESEARCH INTERESTS

My research interest lies primarily on the modulation of neuronal excitability and synaptic transmission in both physiological and pathophysiological conditions. This currently takes several directions: the role of proteinase-activated receptors in central neurones, the function of MAP kinase phosphatases within the CNS and the role of neuroinflammation in CNS disorders. I have an active interest in multidisciplinary research and collaborate with Dr Michele Zagnoni developing microfluidic devices to enable novel neuroscience research and Professor Gail McConnell developing novel imaging techniques for biomedical research. 

PUBLICATIONS


1. Ritchie, L, Tate, R, Chamberlain, LH, Robertson, G, Zagnoni, M, Sposito, T, Wray, S, Wright, JA, Bryant, CE, Gay, NJ & Bushell, TJ 2018, 'Toll-like receptor 3 activation impairs excitability and synaptic activity via TRIF signalling in immature rat and human neurons' Neuropharmacology, vol 135, pp. 1-10. DOI: 10.1016/j. neuropharm. 2018.02.025

2. MacKerron, C, Robertson, G, Zagnoni, M & Bushell, T 2017, 'A microfluidic platform for the characterisation of CNS active compounds' Scientific Reports. DOI: 10.1038/s41598-017-15950-0

3. Salaun, C, Ritchie, L, Greaves, J, Bushell, TJ & Chamberlain, LH 2017, 'The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells' Molecular and Cellular Neuroscience, vol 85. DOI: 10.1016/j. mcn. 2017.07.007

4. Abulkassim, R, Brett, R, MacKenzie, SM & Bushell, TJ 2016, 'Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour' Journal of Neuroimmunology, vol 295-296, pp. 139-147. DOI: 10.1016/j. jneuroim. 2016.04.016

5. Amor, R, McDonald, A, Trägårdh, J, Robb, G, Wilson, L, Abdul Rahman, NZ, Dempster, J, Amos, WB, Bushell, TJ & McConnell, G 2016, 'Widefield two-photon excitation without scanning: live cell microscopy with high time resolution and low photo-bleaching' PLOS One, vol 11, no. 1, 0147115. DOI: 10.1371/journal. pone. 0147115

6. Abdul Rahman, NZB, Greenwood, SM, Brett, RR, Tossell, K, Ungless, MA, Plevin, R & Bushell, TJ 2016, 'Mitogen-activated protein kinase phosphatase-2 deletion impairs synaptic plasticity and hippocampal-dependent memory' Journal of Neuroscience, vol 36, no. 8, pp. 2348-2354. DOI: 10.1523/JNEUROSCI. 3825-15.2016

7. Sposito, T, Preza, E, Mahoney, CJ, Setó-Salvia, N, Ryan, NS, Morris, HR, Arber, C, Devine, MJ, Houlden, H, Warner, TT, Bushell, TJ, Zagnoni, M, Kunath, T, Livesey, FJ, Fox, NC, Rossor, MN, Hardy, J & Wray, S 2015, 'Developmental regulation of tau splicing is disrupted in stem cell derived neurons from frontotemporal dementia patients with the 10+16 splice-site mutation in MAPT' Human Molecular Genetics, vol 24, no. 18, pp. 5260-5269. DOI: 10.1093/hmg/ddv246

8. Robertson, G, Bushell, TJ & Zagnoni, M 2014, 'Chemically induced synaptic activity between mixed primary hippocampal co-cultures in a microfluidic system' Integrative Biology, vol 6, no. 6, pp. 636-644. DOI: 10.1039/ c3ib40221e

9. Gan, J, Greenwood, SM, Cobb, SR & Bushell, TJ 2011, 'Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2' British Journal of Pharmacology, vol 163, no. 5, pp. 984-994. DOI: 10.1111/j. 1476-5381.2011.01293. x

10. Sansig, G, Bushell, T, Clarke, VR, Rozov, A, Burnashev, N, Portet, C, Gasparini, F, Schmutz, M, Klebs, K, Shigemoto, R, Flor, PJ, Kuhn, R, Knoepfel, T, Schroeder, M, Hampson, DR, Collett, VJ, Zhang, C, Duvoisin, RM, Collingridge, GL & van der Putten, H 2001, 'Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7' Journal of Neuroscience, vol 21, no. 22, pp. 8734-8745.

 

Trevor Bushell

Senior Lecturer
Strathclyde Institute of Pharmacy & Biomedical Sciences University of Strathclyde
161 Cathedral Street
Glasgow G4 0RE UK

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