Connecting European Neuroscience

Marianne Fyhn

Programme Committee Member FENS Forum 2020

Curriculum Vitae

Professional and Academic Career

Professional experience

  • 2010: Associate Professor, Department of Biosciences, University of Oslo (UiO).
  • 2013: Head of Center for Integrative Neuroplasticity, supported by the Science Faculty, UiO.
  • 2014-2017: Section Leader, Physiology and Cell Biology (65 researchers and phd-students), UiO.
  • 2008-2010: Post-doctoral researcher, University of California San Francisco, USA.
  • 2005-2008: Post-doctoral researcher, Kavli Institute for Systems Neuroscience, NTNU.

Education

  • 2005: PhD, Neuroscience, Center for the Biology of Memory, Medical Faculty, NTNU, Norway.
  • 1999: MSc, Physiology, Department of Arctic Biology, University of Tromsø, Norway.
  • Supervision of graduate and research fellows
  • 2011-2018: Postdoctoral Research fellows: 8 (five currently in the research group)
  • PhD Students: 3 completed (2017/2018), currently main supervisor of 7 and co-supervisor of 7 PhD students
  • Master Students: 17 completed, currently supervising five students 

Honours and Awards

  • 2008-2010: Personal postdoctoral Research fellowship Research Council of Norway
  • 2007: The Nansen Prize for Young Researchers, Norway
  • 2006: The Donald B. Lindsey’s Prize for best PhD thesis in cognitive Neuroscience, Society for Neuroscience, USA
  • 2006: The Royal Society for Science and Letters prize for Young Researchers, Norway

General Administrative and Organisational Experience

  • 2014: Elected board member of the Norwegian Research School of Neuroscience
  • 2015: Elected board member of the Norwegian Society for Neuroscience
  • 2015: Member of the Academic Committee for Aker Scholarships, Norway.
  • I spearheaded and lead the cross-disciplinary Strategic Research Initiative “Center for Integrative Neuroplasticity” (CINPLA): www.mn.uio.no/ibv/english/research/sections/fyscell/cinpla/ (five PIs and about 35 PhD students, post docs, research fellows and students).
  • I am PI and lead two large projects funded by the Research Council of Norway: “DigiBrain” (2016-2021) 4.5 mill EUROs; “BrainMatrix” (2017-2022) 2.5 mill EUROs.
  • PI and partner in projects together with e. g. University of Cambridge and UCSD.

Research Interests

Understand molecular and neural mechanisms of brain plasticity and behaviors. I was one of the key contributors behind the discoveries of the brain’s navigational system awarded the 2014 Nobel Prize in Physiol or Med to MB and EI Moser. In my own research group, we combine genetic perturbations with imaging and extracellular recordings of behaving animals. We recently showed how a specialized form of extracellular matrix molecules, called perioneuronal nets (PNNs), contribute to regulate adult activity-dependent plasticity and are critical for remote visual fear memories. Combining experimental and computational approaches we also investigate visual information processing in freely moving animals. To facilitate interdisciplinary work, we develop open source tools for meta data handling, storage and data sharing. Heading a project combining human brain activity recordings, patient iPSCs, animal experiments and modelling we link risk gene variants for schizophrenia with neural function.

Selected Publications

Twenty-nine publications in peer reviewed international journals (11 from own research group)

Listed are 10 selected papers. Citations (excluding self-citations as of 05/2018) in brackets:

1. Thompson EH, Lensjø KK, Wigestrand MB, Malthe-Sørenssen A, Hafting T, Fyhn M (2018) Re-moval of perineuronal nets disrupts recall of a remote fear memory. Proc Natl Acad Sci U S A. 2018 Jan 16; 115(3) :607-612.

2. Aasebø IEJ, Lepperød ME, Stavrinou M, Nøkkevangen S, Einevoll G, Hafting T, Fyhn M (2017) Temporal Processing in the Visual Cortex of the Awake and Anesthetized Rat. eNeuro. 2017 Aug 7; 4(4). (Citations: 2)

3. Lensjø KK, Christensen AC, Tennøe S, Fyhn M, Hafting T (2017) Differential Expression and Cell-Type Specificity of Perineuronal Nets in Hippocampus, Medial Entorhinal Cortex, and Visual Cortex Examined in the Rat and Mouse. eNeuro. 2017 Jun 7; 4(3) (Citations: 17)

4. Lensjø KL, Lepperød M, Dick G, Hafting T, Fyhn M (2017) Removal of Perineuronal nets unlocks juvenile plasticity through network mechanisms of decreased inhibition and increased gamma ac-tivity. J Neurosci 37(5): 1269-1283. (Citations: 19)

5. Wigestrand MB, Schiff HC, Fyhn M, LeDoux, JE, Sears RE (2016) Primary auditory cortex regu-lates threat memory specificity. Learn Mem 24(1): 55-58

6. Colgin LL, Denninger T, Fyhn M, Hafting T, Bonnevie T, Jensen O, Moser M-B, Moser EI (2009) Frequency of gamma oscillations routes flow of information in the hippocampus. Nature 462(7271): 353-357. (Citations: 561)

7. Hafting T, Fyhn M, Bonnevie T, Moser M-B, Moser EI (2008) Hippocampus-independent phase precession in entorhinal grid cells. Nature 453:1248-1252. (Citations: 297)

8. Fyhn M, Hafting T, Treves A, Moser M-B, Moser EI (2007) Hippocampal remapping and grid realignment in entorhinal cortex. Nature 446:190-194. (Citations: 381)

9. Hafting T, Fyhn M, Molden S, Moser M-B, Moser EI (2005) Microstructure of a spatial map in the entorhinal cortex. Nature 436:801-806. (Citations: 1794)

10. Fyhn M, Molden S, Witter M P, Moser E I, Moser M-B (2004) Spatial representation in the ento-rhinal cortex. Science 305:1258-1264. (Citations: 808).

Marianne Fyhn

Associate Professor,
Center for Integrative Neuroplasticity,
Department of Biosciences,
University of Oslo,
PB. 1066 Blindern,
NO-0316 Oslo,
Norway.

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