Connecting European Neuroscience

Domna Karagogeos

ORDINARY MEMBER, COMMITTEE ON HIGHER EDUCATION AND TRAINING (CHET) (2016-2018)

CHAIR, COMMITTEE ON HIGHER EDUCATION AND TRAINING (CHET) (2018-2020)

Curriculum vitae

Education

1986 Doctor of Philosophy, Cell and Developmental Biology, Harvard University, Cambridge, USA

1980 Master of Arts, Cell and Developmental Biology, Harvard University, Cambridge, USA

1978 Bachelor of Science, Biology and Chemistry with Honors, Simmons College, Boston, USA

Positions held-training

2008- Professor of Molecular Biology-Developmental Neurobiology, University of Crete (UoC) Medical School

2007-8 Visiting Scientist, NIMR-MRC, Mill Hill, UK (Molecular Neurobiology, Lab. of Dr V. Pachnis)

1999 Associate Professor of Neuroscience, UoC Medical School, Heraklion

1993 Assistant Professor of Neuroscience, UoC Medical School, Heraklion

1991- Affiliated Researcher/Group leader, Institute for Molecular Biology & Biotechnology (IMBB) -FoRTH,

1997 Visiting Professor at the Department of Biology, Ecole Normale Superieure, Paris (Lab. of Dr Marion Wassef)

1995 Visiting Scholar at the Biology Dpt, Boston College (Lab. of Dr Donna Fekete)

1990-93 Instructor of Neuroscience, UoC Medical School, Heraklion,

1986-90 Columbia Univ. Medical School and HHMI, Center for Neurobiol. & Behavior (Postdoctoral fellow in Prof. T. M. Jessell's lab).

Honours and awards

1974 - 1978 Alumnae scholarship of Simmons College

1977 - 1978 Election to the Honor Society, Simmons College

1978 - 1981 Graduate student scholarship of Harvard University

1983 - 1986 A. Phoutrides foundation scholarship at Harvard University

1981 - 1983 A. Onassis Institute scholarship for graduate studies

1986 - 1989 H. Hughes Medical Institute fellowship

1991 EMBO short-term fellow, Ecole Normale Supérieure, Paris

1992 European Science Foundation (ESF) short-term fellow

1993 ESF, National Institute for Medical Research

1993 Award of the Journal Development to initiate collaboration at the National Institute for Medical Research, UK

1995 Fulbright Scholar at the Biology Department, Boston College

1995-96 Human Frontier short-term Fellowship, Biology Department, Boston College.

General administrative and organisational experience 

Director of studies Graduate Program in Neuroscience UoC Medical School since 2014

Chair Department of Basic Science UoC Medical School 2011-13

Member of the Executive Body of UoC Medical School 2011-13

Program Committee Member FENS Forum 2012

President Hellenic Soc. for Neuroscience (HSN) 2008-11

Secretary HSN 2006-8

Governing Council Member FENS 2008-11

Admin. Committees

Graduate Studies

Chair Graduate studies comm. UoC Medical School (since 2014; member since 2010)

Coordination Com. (executive body) for the Graduate Programs in “Neuroscience” (since 1994) &“Molecular Basis of Human Disease”

Admissions Comm. Graduate Program in “Molecular Biology and Biomedicine” (since 1992)

Intern'l Symposia: FENS 1998/Euroglia 2015/FFRM 2015/Satellite Myelin Development ISN 2011

Organizing comm. : HSN 2006-11/FEBS 2008/ISN 2011/FFRM 2015

Public awareness events Peiramatiko high school 2010-13

Administration comm. of HSN Advocacy grant 2012 (FENS-SFN) events organized in Athens and Heraklion.

Expertise in national or international training of students

2 weekly workshops in Modern Imaging Approaches in Biomedical Research, UoC with international participation, 2004 & 5

2013 ISN School on Local Protein Synthesis in Axons and Dendrites, international

Organized/participated in HSN Educational Meeting 2008

As Executive Board and Organizing Comm of HELANI organized 3 National and 1 international meeting including graduate student training in Neuroimmunology

Participant 2016 Summer School on Biomedical Sciences, UoC, international

Trained 15 foreign students for 3 months each through Erasmus programs

Trained undergraduate and graduate students (31 undergraduate theses, 26 Master theses, 13 completed PhD theses, 3 in progress, 10 postdoctoral fellows)

68 students trained in my lab for 3 months each during their Master's

Trained 2 foreign medical students via the Hellenic Medical Students Intern’l Comm. for 1 month

Organized weekly summer schools for high school students by UoC profs and Peiramatiko high school teachers 2010-13.

Research interests

Neuronal development: We study the genetic, molecular and cellular bases of neurogenesis, neuronal migration and axon guidance. We focus on a) the function of the immunoglobulin superfamily protein TAG-1/Contactin-2 and its partners in neuronal migration in mice and b) the role of small GTPases in cortical interneuron development

Axoglial interactions during myelination: Myelinated fibers are organized in distinct functional domains as a consequence of their interactions with glial cells. How is the molecular organization and functional architecture of myelinated fibers achieved? How is it perturbed in de-myelinating diseases, such as multiple sclerosis? We study how TAG-1 and its partners, expressed at specific sites of myelin/axon interactions, contribute to these interactions and how deregulation of their function is involved in de-myelinating diseases.

We use genetic, molecular, biochemical and cellular experimental approaches with emphasis on in vivo studies in transgenic mice.

Publications

1. Bastakis GG, et al., (2015) Tag1 deficiency results in olfactory dysfunction through impaired migration of mitral cells Development 142(24) :4318-28

2. Tivodar S., et al., (2014) Rac-GTPases regulate microtubule stability and axon growth of cortical GABAergic interneurons Cerebral Cortex 25(9) :2370-82

3. Schmidt ER, et al (2014) Subdomain-mediated axon-axon signaling and chemoattraction cooperate afferent innervation of the lateral habenula Neuron 83(2) :372-87

4. Savvaki, M, et al., (2010) The expression of TAG-1 in glial cells is sufficient for the formation of the juxtaparanodal complex and the phenotypic rescue of Tag-1 homozygous mutants in the CNS J. Neurosci. 30(42) : 13943-54

5. Chatzopoulou E, et al. (2008) Structural requirement of TAG-1 for retinal ganglion cell axons and myelin in the mouse optic nerve. J Neurosci. 28(30) :7624-36

6. Ma QH, et al (2008) A TAG1-App signalling pathway through Fe65 negatively modulates neurogenesis. Nat. Cell Biol. 10(3) :283-94

7. Traka, M. *, Goutebroze, L. *, et al., (2003) TAG-1 associates with Caspr-2 and is essential for the molecular organization of juxtaparanodal regions of myelinated fibers J Cell Biol 162(6) : 1161-1172

8. Traka, M. et al., (2002) The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the region of the node of Ranvier in myelinated fibers. J. Neurosci. 22(8) : 3016-3024

9. Furley, A., et al., (1990) The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity. Cell 61(1) : 157-170

10. Dodd, J., et al., (1988) Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons. Neuron 1(2) : 105-116.

Domna Karagogeos

Professor of Molecular Biology/Developmental Neurobiology
University of Crete Medical School & IMBB-FORTH
N. Plastira 100
Vassilika Vouton 70013
Heraklion, Crete, Greece.

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