Connecting European Neuroscience

Stephane Oliet

Programme Committee Member for the FENS Forum 2020

Curriculum Vitae

Professional and academic career

Deputy Director, Neurocentre Magendie Inserm U862
Group leader, Neurocentre Magendie Inserm U862
Permanent position at CNRS (National Center for Scientific Research)
Postdoctoral fellow; UCSF
PhD in Neurological Sciences, McGill University

Honours and awards

Recent Awards
Servier Research Institute Studentship
Heart and Stroke Foundation of Canada Studentship
Max E. Binz Honorary Fellow, Faculty of Graduate Studies & Research, McGill University
International Human Frontier Science Program Organization Fellowship
Special award from the Fondation pour la Recherche Médicale
Annual Award from the magazine La Recherche
NARSAD Independent Investigator
NARSAD Independent Investigator
Laureate of the Pairing Scheme program Team labelled by the Fondation pour la Recherche Médicale

Administrative and organisational experience

General Secretary, 3rd World Congress on Neurohypophysial Hormones
Organization and chairman of the symposium « Gliotransmitters in action », 5th FENS Forum, Vienna, Austria
Co-president of the organizing committee for the French Neuroscience Society meeting
Board member of the French Neuroscience Society
Member of the Administrative board of the University of Bordeaux 2
Section Editor, Neuroscience Co-organizer of the FENS satellite Symposium « Tripartie synapse: from hypothesis to reality», 7th FENS forum, Amsterdam, The Netherlands
Organizer of the Symposium “ Morphofunctional plasticity of the brain”, Satelitte symposium of the 10th Colloquium of the French Neuroscience Society, Bordeaux 2011
Co-organizer of the Symposium “ Metabolic astrocyte-neuron interactions”, Bordeaux 2012
President of the Inserm Commission of specialists for neuroscience (equivalent to study section)

Research interests

My research is focused on neuron-glia interactions in the context of synaptic transmission and plasticity. Our work has contributed significantly to the emerging concept of the tripartite synapse that considers astrocytes as active partners of chemical synapses. We are particularly interested in investigating the glial contribution to NMDA receptor activity through the supply of D-serine, an endogenous co-agonist of these glutamate receptors. We are also examining the morphofunctional plasticity of the tripartite synapse using super-resolution microscopy and the membrane trafficking of key proteins like the glutamate transporter GLT-1, in astrocytes. Finally, part of my team investigates neuron-glia interactions in the context of chronic pain.

Selected Publications

  • Papouin T, Ladépêche L, Ruel J, Sacchi S, Labasque M, Hanini M, Groc L, Pollegioni L, Mothet JP, Oliet SH. (2012) Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell 150(3) :633-46.
  • Massa F, Koehl M, Wiesner T, Grosgean N, Revest JM, Piazza PV, Abrous DN and Oliet SHR (2011) Conditional inhibition of adult neurogenesis impairs hippocampal synaptic plasticity. Proceedings of the National Academy of Science USA 108(16) :6644-6649
  • Henneberger C, Papouin T, Oliet SHR* and Rusakov DA* (2010) Long term potentiation depends on release of D-serine from astrocytes. Nature 463: 232-236 (*corresponding authors)
  • Panatier A, Theodosis DT, Mothet JP, Touquet B, Pollegioni L, Poulain DA and Oliet SHR (2006) Glia-derived D-serine controls NMDA receptor activity and regulates synaptic memory. Cell 125, 775-784.
  • Piet R, Vargova L, Sykova E, Poulain DA and Oliet SHR (2004) Physiological contribution of the astrocytic environnement of neurons on intersynaptic crosstalk. Proceedings of the National Academy of Sciences of the USA., 1001, 2151-2155.
  • Oliet SHR, Piet R and Poulain DA (2001) Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science 292, 923-926.
  • Oliet SHR, Malenka RC and Nicoll RA (1997) Two distinct forms of long-term depression coexist in CA1 hippocamapal pyramidal cells. Neuron 18, 969-982.
  • Oliet SHR, Malenka RC and Nicoll RA (1996) Bidirectional control of quantal size by synaptic activity in the hippocampus. Science 271, 1293-1297.
  • Oliet SHR and Bourque CW (1996) Gadolinium uncouples mechanical detection and osmoreceptor potential in supraoptic neurons. Neuron 16, 175-181.
  • Oliet SHR and Bourque

Stephane Oliet

Deputy Director
Neurocentre Magendie - Inserm U862
146 rue Léo Saignat
33077 Bordeaux