Connecting European Neuroscience

Angela Roberts

Programme Committee Chair FENS Forum 2022 and member FENS Forum 2018

Professional History:
2009- Professor of Behavioural Neuroscience
2009 - Professorial Fellow, Girton College
2005-09 Reader in Behavioural Neuroscience
1996-09 University Lecturer, Dept. of Anatomy, Univ. of Cambridge
1992-96 Royal Society University Research Fellow, Univ. of Cambridge.
1992-99 College Lecturer & Fellow, Girton College, Univ. of Cambridge
1989-92 Research Fellowship, Girton College, Univ. of Cambridge.
1985-92 Post-Doctoral Research Associate, Dept. of Experimental Psychology, Univ. of Cambridge

Member of Editorial Boards:
2020- Neuron Advisory Board
2012- Associate Editor, Frontiers in Behavioral Neuroscience
2011- Field Editor, International Journal of Neuropsychopharmacology

Membership of Research and Grant committees:
2015- International Member, Brain Canada Scientific Advisory Forum
2013 Grant assessor, European Space agency
2013- Executive Committee member, Cambridge Neuroscience
2009-15 Executive committee member, Behavioural and Clinical Neuroscience Institute

Membership of Committees of Learned Societies:
2018- International Neuroscience Advisor for Gruber Prize in Neuroscience
2018- Online Programme Steering Committee, Society for Neuroscience
2015-20 British Association for Psychopharmacology Council
2012-18 Understanding Animals in Research Council
2010-13 Animals in Research committee for Society for Neuroscience
2000-02 European Brain and Behaviour Society Committee

Honours and awards
2020 European Brain and Behaviour Prize Lecture at FENS
2020 Goldman-Rakic Prize for Outstanding Achievements in Cognitive Neuroscience, awarded by the Brain and Behavior Research Foundation.
2016 Elected Fellow of the academy of Medical Sciences, Great Britain
1996 Best paper of the Year in 1996 in Behavioral Neuroscience, awarded by the American Psychological Association, Division 6.

Research interests

I am interested in the brain networks underlying cognitive and emotional behavior in primates. In particular, my research focuses on the executive control functions of the prefrontal cortex and related brain structures, including the basal ganglia and the amygdala, and the modulation of these circuits by the monoamines. Our experimental approach combines neural, pharmacological, cardiovascular, neuroimaging and genetic techniques with sophisticated cognitive and emotional testing procedures. Since many of the behavioural tests that we use can also be administered to patients, our results directly extrapolate to the clinical setting. My research has been continuously funded by the Medical Research Council and the Wellcome Trust over the last 28 years.

List of 10 major publications

10. Alexander L., Wood C.M., Gaskin, P.R.L., Sawiak S.J., Fryer T.D., Hong, Y.T., McIver L., Clarke, H.F., Roberts A.C. Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioural and neural responses to threat reactivity (2020) Nature Communications (in press).
9. Stawicka, Z.M., Massoudi R., Horst, N.K., Koda, K., Alexander L., Gaskin, P.R.L., Santangelo A.M., Anderson L., Cockcroft G.J., Wood C.M., Roberts A.C. Ventromedial prefrontal area 14 provides opposing regulation of threat and reward-elicited responses in the common marmoset (2020) Proceedings of the National Academy of Sciences 117: 25116-25127.
8. Alexander L., Gaskin P., Sawiak S.J., Fryer T., Hong Y.T., Cockcroft G., Clarke H.F., Roberts A.C. Fractionating anhedonia by over-activating area 25 of primate subgenual anterior cingulate cortex (2019) Neuron 101:307-320.
7. Santangelo A.M., Sawiak S., Fryer T., Hong Y., Shiba Y., Clarke H.F., Riss P.J., Ferrari V., Tait R., Suckling J. Aigbirhio F.I., and Roberts A.C. Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates (2019) Proceedings of the National Academy of Sciences 116:14761-14768
6. Santangelo, A.M. Ito, M., Shiba, Y., Clarke H.F., Schut E.H.S. Cockroft G., Ferguson-Smith A.C., Roberts A.C. Novel primate model of serotonin transporter genetic polymorphisms associated with gene expression, anxiety and sensitivity to antidepressants. (2016) Neuropsychopharmacology 41:2366-76.
5. Clarke H.F., Horst N., Roberts A.C. Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making. (2015) Proceedings of the National Academy of Sciences 112:4176-81.
4. Agustín-Pavón C., Braesicke K., Shiba Y., Santangelo A.M., Mikheenko Y., Cockroft G., Asma F., Clarke H., Man M., Roberts A.C. Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion. (2012) Biological Psychiatry 72:266-272.
3. Clarke, H.F., Dalley, J.W., Crofts, H.S., Robbins, T.W., Roberts, A.C. Cognitive inflexibility after prefrontal serotonin depletion. (2004) Science 7:878-880.
2. Arana, F.S., Parkinson, J.A. Hinton, E., Holland, A., Owen, A., Roberts, A.C. Dissociable Contributions of the Human Amygdala and Orbitofrontal Cortex to Incentive Motivation and Goal Selection. (2003) Journal of Neuroscience 23:9632-9638. (Editor’s Choice for Science (2003), vol.302: 953)
1. Dias, R. Robbins, T. W., Roberts, A. C. (1996) Dissociation in the prefrontal cortex of affective and attentional shifting. Nature 380:69-72

Angela Roberts

Cambridge
UK

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