Connecting European Neuroscience

Rosa Señarís Rodríguez

Member of CARE (2018 - 2020)


Professional and academic career 

- Graduate in Medicine (1986). MD. PhD in Medicine (Neuroscience). University of Santiago de Compostela (1990).  

- Postdoctoral fellow in the Department of Neurobiology (MRC). Cambridge. UK (1991-1993), in the Department of Neurosciences. University of Aarhus (1994), and in the Department of Medicine. University of McGill. Montreal. Canada (1996). 

- Full Professor of Physiology. University of Santiago de Compostela. Spain. 

General administrative and organisational experience 

- Director Doctoral programme in Endocrinology. University of Santiago de Compostela. (2007-2011) 

- Head of Department. Department of Physiology. University of Santiago de Compostela (2011-2014)  

Research interests

-  Neuroendocrinology, metabolism and energy homeostasis

-  Cancer metabolism

Selected Publications

- Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice.

Reimúndez A, Fernández-Peña C, García G, Fernández R, Ordás P, Gallego R, Pardo-Vazquez JL, Arce V, Viana F, Señarís R.

J Neurosci. 2018 Apr 11;38(15):3643-3656. doi: 10.1523/JNEUROSCI.3002-17.2018.

PMID: 29530988

- Leptin resistance during pregnancy is also exerted at the periphery.

Trujillo-Güiza ML, Señarís R.

Biol Reprod. 2018 May 1;98(5):654-663. doi: 10.1093/biolre/ioy024.

PMID: 29385412

- Lipoprotein internalisation induced by oncogenic AMPK activation is essential to maintain glioblastoma cell growth.

Ríos M, Foretz M, Viollet B, Prieto A, Fraga M, García-Caballero T, Costoya JA, Señarís R.

Eur J Cancer. 2014 Dec;50(18):3187-97. doi: 10.1016/j.ejca.2014.09.014.

PMID: 25450947

- Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner.

Ferrer B, Navia B, Giralt M, Comes G, Carrasco J, Molinero A, Quintana A, Señarís RM, Hidalgo J.

Brain Behav Immun. 2014 Aug;40:121-30. doi: 10.1016/j.bbi.2014.03.001.

PMID: 24632224

- TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins.

Meseguer V, Alpizar YA, Luis E, Tajada S, Denlinger B, Fajardo O, Manenschijn JA, Fernández-Peña C, Talavera A, Kichko T, Navia B, Sánchez A, Señarís R, Reeh P, Pérez-García MT, López-López JR, Voets T, Belmonte C, Talavera K, Viana F.

Nat Commun. 2014;5:3125. doi: 10.1038/ncomms4125.

PMID: 24445575

- AMPK activation by oncogenesis is required to maintain cancer cell proliferation in astrocytic tumors.

Ríos M, Foretz M, Viollet B, Prieto A, Fraga M, Costoya JA, Señarís R.

Cancer Res. 2013 Apr 15;73(8):2628-38. doi: 10.1158/0008-5472.CAN-12-0861.

PMID: 23370326 

- Hyperphagia and central mechanisms for leptin resistance during pregnancy.

Trujillo ML, Spuch C, Carro E, Señarís R.

Endocrinology. 2011 Apr;152(4):1355-65. doi: 10.1210/en.2010-0975.

PMID: 21303957

- Perinatal overfeeding in rats results in increased levels of plasma leptin but unchanged cerebrospinal leptin in adulthood.

López M, Tovar S, Vázquez MJ, Nogueiras R, Seoane LM, García M, Señarís RM, Diéguez C.

Int J Obes (Lond). 2007 Feb;31(2):371-7.

PMID: 16801924

- A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat.

López M, Seoane LM, Tovar S, García MC, Nogueiras R, Diéguez C, Señarís RM.

Diabetologia. 2005 Jan;48(1):140-8.

- Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamus.

López M, Seoane LM, Tovar S, Nogueiras R, Diéguez C, Señarís R.

Eur J Neurosci. 2004 Apr;19(8):2080-8

PMID: 15090035

- Hypothalamic levels of NPY, MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat: role of prolactin.

García MC, López M, Gualillo O, Seoane LM, Diéguez C, Señarís RM.

FASEB J. 2003 Aug;17(11):1392-400.

PMID: 12890692

- Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptor subtypes in the hypothalamus during pregnancy and lactation.

García MD, Casanueva FF, Diéguez C, Señarís RM.

Biol Reprod. 2000 Mar;62(3):698-703.

PMID: 10684812

- Synthesis of leptin in human placenta.

Señarís R, Garcia-Caballero T, Casabiell X, Gallego R, Castro R, Considine RV, Dieguez C, Casanueva FF.

Endocrinology. 1997 Oct;138(10):4501-4.

PMID: 9322972

- Regulation of in vivo growth hormone secretion by leptin.

Carro E, Señaris R, Considine RV, Casanueva FF, Dieguez C.

Endocrinology. 1997 May;138(5):2203-6.

PMID: 9112421

- Distribution of somatostatin receptors 1, 2 and 3 mRNA in rat brain and pituitary.

Señarís RM, Humphrey PP, Emson PC.

Eur J Neurosci. 1994 Dec 1;6(12):1883-96.

PMID: 7704298



Rosa Señarís Rodríguez

Institution, department: University of Santiago de Compostela. Department of Physiology. CiMUS.
Address: Avenida de Barcelona, 1. Spain.