Connecting European Neuroscience

Ana-Maria Zăgrean

Ordinary member, Committee for Higher Education and Training (CHET) (July 2020 - July 2022)

Curriculum Vitae                                                  

Professional and academic career

Education

2019, Habilitation
2003, Ph.D. in Medical Sciences, Specialty Neurology
1995, M.D., Faculty of Medicine, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania

Present positions

Professor in Physiology and Neuroscience, Division of Physiology and Neuroscience, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania 

Past positions:

Positions at the Division of Physiology and Neuroscience, Carol Davila University of Medicine and Pharmacy:
2013-2020, Associate Professor
2003-2013, Lecturer
2000-2003, Assistant professor
1995-2000, Research associate and Teaching assistant

Honours and awards

Fellowships
2006-2008, Honorary Research Fellow, Div. of Medical Sciences, Birmingham University, UK
2005-2007, Junior Fellowship of The Physiological Society (UK), Div. of Medical Sciences, Birmingham University, UK
2003, Postdoctoral research work, Div. of Medical Sciences, Birmingham University, UK
2000-2001, Doctoral fellowship at Karolinska Institute, Dept. of Clinical Neuroscience, Sweden

Awards
2019, IBRO Global Engagement Seed Grant
2016, Physiological Society grant, Physiology2016
2012, Gheorghe Marinescu Prize of the National Neuroscience Society of Romania
2005, Junior Fellowship Award, The Physiological Society
2001, Young Investigators Award, IUPS

Research projects
2019-present, Managing Committee member, COST Action CA18240
2011-present, Scientific Advisory Board member, ERA-Net NEURON and Neuron Cofound
2012-2013, FENS History of Neuroscience Online Project “Historiography of Neurosciences in Eastern Europe, Romania, 1870-1970”.
2001-present, funding from national research grants (14 out of 20 grants as principal investigator or key person)

General administrative and organisational experience

Professional assignments - Societies
2020-2022, ordinary member, FENS-CHET (appointed as IBRO‐PERC representative)
2017-present, member of the IBRO-PERC committee
2003-2004, IBRO’s Regional correspondent for Romania
2001-present, secretary of the National Neuroscience Society of Romania (SNN)

Professional assignments - University
2019-present, member in the ethical committee of Carol Davila University of Medicine and Pharmacy
2016-present, member in the scientific committees for PhD Students/academic members at Bucharest University and Carol Davila University of Medicine and Pharmacy
2005-present, evaluator in the National Register of the Experts for Research and Education
2003-present, coordinator for Physiology and Neuroscience for the English Module Medical Students at Carol Davila University of Medicine and Pharmacy
2003-present, coordinator and founder of the Neuronal Cell Culture Lab, Division of Physiology and Neuroscience, Carol Davila University of Medicine and Pharmacy
2001-present, supervision of research activity for undergraduate, doctoral and postdoc students
Ad-hoc reviewer activity for journals such as Neonatology, Frontiers in Neurosciences, Neuroscience Letters, PlosOne, Cellular and Molecular Neurobiology, etc.

Professional memberships

from 2006, European Dana Alliance for the Brain (EDAB)
from 2003, The Physiological Society (UK),
from 2001, (founding member); National Neuroscience Society of Romania (SNN)
from 2001, Federation of European Neuroscience Societies (FENS)
from 2001, International Brain Research Organization (IBRO)
from 1996, Federation of European Physiological Societies (FEPS)
from 1996, International Union of Physiological Sciences (IUPS)
from 1996, Romanian Society of Physiological Sciences (SRSF)

Scientific meetings organization

July 2019, Member in the scientific committee, FENS Featured Regional Meeting, Belgrade,
September 2017, Symposium organizer, FENS Featured Regional Meeting, Pecs
From 2003, Secretary of the organizing committee for the annual meetings of the National Neuroscience Society of Romania (SNN), with national and international participation
September 2003, Secretary of the local organizing committee for The Physiological Society International Workshop in Neuroscience, Bucharest

Public engagement activities

Yearly since 2004, Organizer of annual neuroscience advocacy and outreach events such as Brain Awareness Week (BAW), lab open days, workshops and conferences at Carol Davila University of Medicine and Pharmacy
2011, Participation in organizing a Romanian action group (NAG) for European Brain Council (EBC) at Carol Davila University of Medicine and Pharmacy
June 2007, Organizer of the EDAB Public Lecture on Art-Science Interference, accompanied by an art exhibition, Romanian Academy Library, Bucharest

Research interests

I am interested in understanding how brain responds to asphyxia/ischemia and reperfusion, and to altered states of excitability, in immature and mature brain, in in vivo (perinatal asphyxia, cerebral ischemia, experimental epilepsy) and in vitro (oxygen-glucose deprivation) experimental paradigms. By investigating epigenetic, genetic, biochemical, electrophysiological and behavioral aspects of brain response to various metabolic and environmental stressors during different developmental stages, I am looking towards brain recovery and neuroprotective strategies. In the context of perinatal asphyxia, I am investigating the way gestational and perinatal factors are influencing offspring’s brain development, and what strategies could be used to improve the short- and long-term outcomes.
http://orcid.org/0000-0002-4302-629X

Selected Publications

Zagrean AM, Grigoras IF, Iesanu MI, Ionescu RB, Chitimus DM, Haret RM, Ianosi B, Ceanga M, Zagrean L. Neuronal transmembrane chloride transport has a time-dependent influence on survival of hippocampal cultures to oxygen-glucose deprivation. Brain Sci. 2019, 9, 360.

Pavel B, Menardy F, Rotaru D, Paslaru AC, Acatrinei C, Zagrean L, Popa D, Zagrean AM. Electrical stimulation in the claustrum area induces a deepening of isoflurane anesthesia in rat. Brain Sci. 2019;9(11):304.

Spataru A, Le Duc D, Zagrean L, Zagrean AM. Ethanol exposed maturing rat cerebellar granule cells show impaired energy metabolism and increased cell death after oxygen-glucose deprivation. Neural Regen Res 2019, 14(3):485-490

Zagrean AM, Hermann DM, Opris I, Zagrean L, Popa-Wagner A. Multicellular crosstalk between exosomes and the neurovascular unit after cerebral ischemia. therapeutic implications. Front Neurosci. 2018;12:811.

Georgescu EL, Georgescu IA, Zahiu CDM, Şteopoaie AR, Morozan VP, Pană AŞ, Zăgrean AM*, Popa D*. Oscillatory cortical activity in an animal model of dystonia caused by cerebellar dysfunction. Front Cell Neurosci. 2018 Nov 6;12:390 (*equal contribution).

Isac S, Panaitescu AM, Iesanu M, Grigoras IF, Totan A, Udriste A, Cucu N, Peltecu G, Zagrean L, Zagrean AM. Maternal high-fat diet modifies the immature hippocampus vulnerability to perinatal asphyxia in rats. Neonatology, August 2018, 114 (4), 355-361

Cǎlin A, Stancu M, Zagrean AM, Jefferys JGR, Ilie AS, Akerman CJ. Chemogenetic recruitment of specific interneurons suppresses seizure activity. Front Cell Neurosci. 2018;12:293.

Isac S, Panaitescu AM, Spataru A, Iesanu M, Totan A, Udriste A, Cucu N, Peltecu G, Zagrean L, Zagrean AM. Trans-resveratrol enriched maternal diet protects the immature hippocampus from perinatal asphyxia in rats. Neuroscience Letters, June 2017, 653, 308-313

Le Duc D, Spataru A, Ceanga M, Zagrean L, Schöneberg T, Toescu EC, Zagrean AM. Developmental exposure to ethanol increases the neuronal vulnerability to oxygen-glucose deprivation in cerebellar granule cell cultures. Brain Res. 2015; 1614:1-13.

Ceanga M, Spataru A, Zagrean AM. Oxytocin is neuroprotective against oxygen-glucose deprivation and reoxygenation in immature hippocampal cultures. Neurosci Lett. 2010 Jun 14;477(1):15-8.

Ana-Maria Zăgrean

Division of Physiology and Neuroscience, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy,
050474 Bucharest, Romania
ana-maria.zagrean@umfcd.ro

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