Connecting European Neuroscience

Zeljka Krsnik

Professional and academic career

University of Zagreb, School of Medicine, Croatian Institute for Brain Research (CIBR), Zagreb, Croatia
Associate Professor of Neuroscience (2019-present)
Assistant Director for Management and Public Relations at CIBR (2016-present)
Head of Laboratory for Digitalization of Zagreb Brain Collection (2013-present)
Head of Laboratory for Neurogenomics and In Situ Hybridization (2013-present) 

Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, USA
Visiting Scientist (November 2014 - January 2015)

Yale University, School of Medicine, Neurobiology Department, New Haven, CT, USA
Postdoctoral Associate (2006-2011)

University of Zagreb, Faculty of Science, Zagreb, Croatia
PhD in Molecular Biology (2005)



Young IBRO (International Brain Research Organization) Committee, Chair (2018- present)
ALBA Network, Board of Directors (2018- present)
IBRO Executive Committee, member (2018-present)
IBRO Alumni Committee, Chair (2017-2018)
Croatian Science Foundation, Study section panel member (2016-2020)
Croatian Academy of Sciences and Arts, Committee member for Neuroscience and Brain Disorders (2015-present)



Croatian Academy of Sciences and Art Foundation, project: Digitalization of The Zagreb Neuroembryological Collection (2014)
IBRO Return Home Program, fellowship (2013)
University of Zagreb, research mobility fellowship (2013/14)
Foundation M. Cackovic, University of Zagreb, travel award (2003)
FENS/IBRO International Summer School travel award (2003)
FENS/IBRO International Summer School travel award (2001)
Cajal Club, annual membership & travel award (2001)


Research interest

The main research focus of my lab is to understand the molecular and cellular mechanisms of the human neurodevelopmental processes and their comparative analyses with rodents and non-human primates. One line of our research is spatio-temporal analysis of the human brain transcriptome during development by leveraging innovative technology with the in situ hybridization of selected candidate genes coupled to immunohistochemistry or immunoflurescence.

Selected publications

Krsnik Z, Popovitchenko T, Rasin MR (2020) Transcriptional and Post-Transcriptional Mechanisms of Neuronal Migration, in Comprehensive Developmental Neuroscience: Cellular Migration and formation of neuronal connections, 2nd edition, Vol 1, Rubenstein, JLR and Rakic, P (ed.), Elsevier 

Popovitchenko T, Park Y, Page NF, Luo X, Krsnik Z, Liu Y, Salamon I, Stephenson JD, Kraushar ML, Volk NL, Patel SM, Wijeratne HRS, Li D, Suthar KS, Wach A, Sun M, Arnold SJ, Akamatsu W, Okano H, Paillard L, Zhang H, Buyske S, Kostovic I, De Rubeis S, Hart RP, Rasin MR. (2020) Translational derepression of Elavl4 isoforms at their alternative 5' UTRs determines neuronal development. Nature Communications 11(1):1674.

Kostović, I; Žunić Išasegi, I; Krsnik, Z (2018) Sublaminar organization of the human subplate: developmental changes in the distribution of neurons, glia, growing axons and extracellular matrix. J Anat doi: 10.1111/joa.12920

Li M, et al (2018) Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science. 362(6420). pii: eaat7615. doi: 10.1126/science.aat7615.

Hrabac P, Bosak A, Vuksic M, Judas M, Kostovic I, Krsnik Z (2018) The Zagreb Collection of human brains: entering the virtual world. Croat Med J. 59(6):283-287.

Krsnik Z, Majić V, Vasung L, Huang H, Kostović I (2017) Growth of thalamocortical fibres to somatosensory cortex in the human fetal brain. Frontiers in Neuroscience 11:233

Krsnik Z and Sedmak G Gene expression in the frontal lobe (2017) in Executive Functions in Health and Disease, published by Elsevier (Elkhonon Goldberg ed.) Elsevier. Academic Press. London, 41-69

Duque A, Krsnik Z, Kostovic I, Rakic P (2016) Secondary expansion of the transient subplate zone in the developing cerebrum of human and nonhuman primates. PNAS USA 113(35):9892-7

Kang H., Kawasawa Y., Cheng F., Zhu Y., Xu, X., Li M., Sousa A., Pletikos M., Meyer K., Sedmak G., Guennel T., Shin Y., Johnson M.B., Krsnik Z., Mayer S., Fertuzinhos S., Umlauf S., Lisgo S.N., Vortmeyer A., Weinberger D., Mane, S., Hyde T.M., Huttner A., Reimers M., Kleinmann J., Sestan N. (2011): Spatiotemporal transcriptome of the human brain. Nature 478(7370):483-9.

Johnson MB, Kawasawa YI, Mason CE, Krsnik Z, Coppola G, Bogdanovic D, Geschwind DH, Mane SM, State M, Sestan N (2009) Genetic complexity of human brain development and evolution revealed through global exon usage analysis. Neuron 62: 494-509.

Zeljka Krsnik, University of Zagreb, School of Medicine, Croatian Institute for Brain Research (CIBR), Zagreb, Croatia