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Brain cells, and especially neurons, have developed a high degree of polarisation as well as micro- and nanoscale compartmentalisation of cellular components when compared to other cell types. Cellular neuroscience has benefited in the last years from the development of sophisticated high-resolution imaging techniques including subcellular nanoscopy and the development of novel probes that allow the visualization of neuronal architecture and function in vitro and in the brain in vivo. These advances have placed cellular neuroscientists at the forefront of cell biology and have allowed them to study at unprecedented spatial and temporal resolution processes such as synaptic transmission, receptor trafficking, or morphological adaptations during brain plasticity in diverse models ranging from cultured neurons to the entire brain. The course and its participants will greatly benefit from the infrastructure provided by the Bordeaux Imaging Centre. Finally, this Course will emphasize how new techniques can address specific biological issues and lead to new concepts and discoveries in cellular neuroscience.
Modern neuronal cell biology relies on a large array of advanced techniques. The past decade has produced a revolution in technological innovations and the interweaving of approaches at the molecular, cellular, network and organismal levels (“from genes to behaviour”). This advanced course allows the students to obtain hands-on experience with innovative techniques expected to be central in cellular neuroscience in the coming decade. These techniques focus on the study of cell proliferation and migration, axonal growth, cellular trafficking, synaptogenesis as well as mature cell function, in particular synaptic transmission and plasticity. Techniques will include in vitro and in vivo gene transfer (including viral vector technology and single cell electroporation), cell and tissue imaging by confocal imaging and light sheet microscopy, photomanipulation in living tissue and optophysiology, patch clamp electrophysiology, imaging of proteins and lipids by super-resolution microscopy (STED and PALM/STORM), single-particle tracking methodologies, correlative light electron microscopy (CLEM), live imaging of protein interactions (FRET, FLIM). Rodent and human model systems (iPSCs, organoids) are central, and successful invertebrate models such as Drosophila and C. elegans will be also available.
Vivian Budnik, University of Massachusetts Medical School, USA
Pietro De Camilli, Yale School of Medicine, USA
Mike Fainzilber, Weizmann Institute of Science, Israel
Erika Holzbaur, University of Pennsylvania, PA, USA
Erik Jorgensen, University of Utah, Salt Lake City, USA
Gary Lewin, Max Delbrück Center for Molecular Medicine, Germany
Klaus Nave, Max Planck Institute, Germany
Silvio O. Rizzoli, University of Göttingen Medical Center, Germany
Frédéric Saudou, Grenoble University Hospital CHUGA, France
Gipi Schiavo, University College London, UK
Stephan Sigrist, Freie Universitat, Berlin, Germany
Patrik Verstreken, VIB-KU Leuven Center for Brain & Disease Research, Belgium
More information on keynote speakers
Laura Andreae, King’s College London, UK
Mathias A. Böhme, Leibniz Institute for Molecular Pharmacology, Berlin
Maxime Cazorla, Grenoble Institute of Neuroscience, France
Ingrid Chamma, CNRS UMR 5297 – INSERM - Université Bordeaux Segalen, France
Soham Chanda, Stanford University School of Medicine, USA
Daniela C. Dieterich, Otto-von-Guericke University (OVGU) Magdeburg, Germany
Helge Ewers, Freie Universitat, Berlin, Germany
Anna Fejtova, University Hospital Erlangen, Germany.
Gregory Giannone, IINS, Bordeaux, France
Cyril Hanus, Institute for Psychiatry and Neurosciences of Paris, France
Etienne Herzog, CNRS, Interdisciplinary Institute for NeuroScience, Bordeaux, France
Robin Hiesinger, Free University Berlin, Germany
Janine Kirstein, PhD, Leibniz Institute for Molecular Pharmacology (FMP), Germany
Anke Müller, Otto-von-Guericke University (OVGU) Magdeburg, Germany
Ira Milosevic, University Medical Center (UMG), Germany
Valentin Nägerl, IINS, University of Bordeaux, France
José Filipe Nunes Vicente, IINS, Bordeaux, France
David Owald, Institut für Neurophysiologie, Charité, Germany
Andrew Plested, Leibniz Forschungsinstitut für Molekulare Pharmakologie, Germany
Christian Rosenmund, Charité – Universitätsmedizin Berlin, Institute of Neurophysiology, Germany
Guillaume Van Niel, University Paris Descartes, France
Alexander Walter, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Germany
Shigeki Watanabe, Johns Hopkins University, USA
Marius Wernig, Stanford University, USA
More information on instructors
Download the list of course projects
Fee : 3.500 € (includes tuition fee, accommodation and meals)
The CAJAL programme offers 4 stipends per course (waived registration fee, not including travel expenses). Please apply through the course online application form. In order to identify candidates in real need of a stipend, any grant applicant is encouraged to first request funds from their lab, institution or government.
Kindly note that if you benefited from a Cajal stipend in the past, you are no longer eligible to receive this kind of funding. However other types of funding (such as partial travel grants from sponsors) might be made available after the participants selection process, depending on the course.
This course is organised in partnership with the Bordeaux Imaging Center (BIC).
Bordeaux Neurocampus, France
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