Job ID: 111348

PhD position in neuroscience in Bordeaux

Position: Ph.D. Student

Deadline: 1 September 2023

Employment Start Date: 1 October 2023

Contract Length: 3 years

City: Bordeaux

Country: France

Institution: University of Bordeaux

Department: Interdisciplinary Institute for Neuroscience


Structural remodeling of hypothalamic circuits by microglia in obesity

Keywords: STED imaging, Neuronal plasticity, Microglia, Electrophysiology, Obesity, Hypothalamus
Co-Supervisors: Valentin Nägerl ( / Agnès Nadjar (

The PhD project aims to unravel the physical and molecular interactions between microglia and neurons in the hypothalamus in a mouse model of obesity, where it has been shown that an obesogenic diet induces microglial neuroinflammation and major changes in the functional neuroanatomy of the hypothalamus. We will use a combination of super-resolution microscopy and opto/electrophysiological approaches to study in living brain slices alterations in microglia-neuron interactions brought on by an obesogenic diet.