Job ID: 114356

PhD “Neurodegeneration as Synaptopathy”

Position: Ph.D. Student

Deadline: 30 September 2023

Employment Start Date: 1 November 2023

Contract Length: initially 2 years

City: Ulm

Country: Germany

Institution: Ulm University

Department: Anatomy and Cell Biology/DZNE


The Institute of Anatomy and Cell Biology/DZNE Ulm site invites applications for a

PhD-student (f/m/d)


The Institute of Anatomy and Cell Biology / DZNE research group Translational Protein Biochemistry (Prof. Dr. Tobias M. Böckers) focusses on pathomechanisms in neurodegenerative diseases using a wide set of models (i.e.: mouse models, expression of relevant proteins in human tissue). In particular, components of the development of Amyotrophic lateral sclerosis (ALS), Frontotemporal Dementia (FTD) and Alzheimer (AD) diseases are of major interest. Furthermore, the research efforts under the keyword “Neurodegeneration as Synaptopathy” and the associated implications for new therapeutic approaches will be intensified. In addition, the role of the cellular stress response and heat shock proteins in neurodegenerative diseases will be further investigated. For that purpose, an Alzheimer 3D cell culture model based on human neural progenitor cells (hNPCs) expressing familial AD mutations as well as patient derived induced pluripotent stem cells (hiPSC) will be used. Ultimately, small peptides and heat shock protein inducing agents as candidates for disease modifying capability in neurodegenerative diseases will be investigated.

Your tasks

  • Active participation in experimental work, experimental design, data generation, data analyses, and interpretation of results
  • Prepare and write manuscripts for publication in international scientific journals
  • Oral presentation of results on local, national, and international conferences
  • Experimental work includes molecular biology, especially cell culture of induced pluripotent stem cells


  • A keen interest in molecular biology and working with induced pluripotent stem cells
  • Experience in molecular biology and handling of pluripotent stem cells is advantageous
  • Successful candidates have a master’s degree in molecular biology, neuroscience, biochemistry (or a master’s degree in a related field)
  • English language is a prerequisite

We are looking for candidates who are open-minded, creative team-player, enthusiastic, have strong analytical skills, think critically, and with good social skills

We offer

  • Working in an international team within a stimulating research environment and with very well equipped laboratories
  • An international environment characterized by a strong focus on science and research
  • A high potential for the individual development of our employees

Contact details

Prof. Dr. Tobias Böckers,

Application files

  • CV
  • Motivation letter
  • Bachelor and Master qualifications
  • Recommendation letters

Application deadline

30.09.2023 ?